Showing Protein Fructose-1,6-bisphosphatase 1 (BMDBP00176)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00176 | ||
| Secondary Accession Numbers | None | ||
| Name | Fructose-1,6-bisphosphatase 1 | ||
| Synonyms | Not Available | ||
| Gene Name | FBP1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Carbohydrate transport and metabolism | ||
| Specific Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. | ||
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 8 | ||
| Locus | Not Available | ||
| SNPs | FBP1 | ||
| Gene Sequence |
>1017 bp ATGACGGACCAGGCAGCCTTCGACACCAATATCGTCACCGTGACCCGCTTCGTCATGGAA GAGGGCAGGAAGGCCCGTGGCACGGGCGAGATGACCCAACTGCTCAACTCGCTTTGCACC GCGGTCAAAGCCATCTCCACGGCCGTGCGCAAGGCGGGCATCGCGCACCTCTATGGAATT GCTGGCACTACCAATGTGACGGGAGATCAAGTGAAGAAGCTGGATGTCCTCTCCAATGAC CTGGTTGTTAATGTGTTAAAGTCATCTTTTGCTACCTGTGTTCTTGTGTCAGAAGAAGAT GAACATGCCATAATAGTAGAACCTGAGAAAAGGGGTAAATATGTGGTCTGTTTTGATCCC CTTGATGGATCATCCAACATCGACTGCCTTGTGTCCATTGGAACCATCTTTGGCATCTAC AAAAAGATTTCGAAAGATGACCCTTCTGAGAAGGACGCTCTGCAGCCAGGCCGGAACCTG GTGGCTGCTGGCTATGCGCTCTATGGCAGTGCCACTATGTTGGTCCTGGCCATGGCGAAT GGAGTCAACTGCTTCATGCTGGACCCGGCCATTGGAGAGTTCATTTTGGTGGACAGGGAT GTGAAGATCAAAAAGAAAGGGAGCATCTATAGCCTCAATGAAGGCTATGCGAAGGACTTT GATCCTGCCCTCACCGAGTATGTCCAGAGGAAGAAGTTCCCCCCAGACAACTCAGCCCCC TATGGCGCCAGGTACGTGGGCTCCATGGTAGCCGATGTACACCGCACCCTAGTCTATGGA GGGATCTTTATGTATCCAGCTAACAAGAAAAGCCCCAGTGGAAAGCTGAGACTACTGTAT GAATGTAACCCCATGGCCTATGTCATAGAGAAGGCAGGAGGAATGGCTACCACCGGGAAG GAAACTGTGCTGGACATTGTTCCCACTGACATCCATCAGAAGTCGCCCATCATCTTGGGG TCTCCTGAAGATGTGACTGAGTTCCTGGAGATATACAAGAAGCATGCTGCCAAATGA |
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| Protein Properties | |||
| Number of Residues | 338 | ||
| Molecular Weight | 36728.0 | ||
| Theoretical pI | 7.01 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Fructose-1,6-bisphosphatase 1 MTDQAAFDTNIVTVTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGI AGTTNVTGDQVKKLDVLSNDLVVNVLKSSFATCVLVSEEDEHAIIVEPEKRGKYVVCFDP LDGSSNIDCLVSIGTIFGIYKKISKDDPSEKDALQPGRNLVAAGYALYGSATMLVLAMAN GVNCFMLDPAIGEFILVDRDVKIKKKGSIYSLNEGYAKDFDPALTEYVQRKKFPPDNSAP YGARYVGSMVADVHRTLVYGGIFMYPANKKSPSGKLRLLYECNPMAYVIEKAGGMATTGK ETVLDIVPTDIHQKSPIILGSPEDVTEFLEIYKKHAAK |
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| External Links | |||
| GenBank ID Protein | AAI02975.1 | ||
| UniProtKB/Swiss-Prot ID | Q3SZB7 | ||
| UniProtKB/Swiss-Prot Entry Name | F16P1_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | BC102974 | ||
| GeneCard ID | FBP1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||