Showing Protein Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (BMDBP00177)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00177 |
| Secondary Accession Numbers | None |
| Name | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
| Synonyms | Not Available |
| Gene Name | ENPP2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in alkylglycerophosphoethanolamine phosphodies |
| Specific Function | Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine (PubMed:12119361). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor (By similarity). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 14 |
| Locus | Not Available |
| SNPs | ENPP2 |
| Gene Sequence |
>2667 bp ATGGCCAGGAGACGCTCCTGCCAGCTCCATCAGGTGATATCTCTGTTCACTTTTGCCGTC GGTGTCAATATCTGCTTAGGAGTCACAGCAAATCGAATTAAGAGGGCAGAAGGATGGGGT GAAGGCCCTCCTACAGTGTTATCAGACTCCCCCTCGATCAACATCTCTGGGTCTTGCAAG GGCAGATGCTTTGAACTTCAAGAGGCTGGACCCCCTGATTGTCGATGTGACAACTTGTGT AAGAGCTATAGCAGCTGCTGCCTTGACTTTGATGAGCTCTGCTTGAAGACAGCTGGTGGC TGGGAGTGTACCAAGGACAGATGCGGAGAAGTAAGAAATGAAGACCATGCTTGTCACTGC TCGGAGGACTGCTTGGCCCGGGGAGACTGTTGCACTAATTACCAAGTGGTTTGCAAAGGA GAGTCTCACTGGGTGGATGATGACTGTGAGGAAATAAAGACCCCAGAATGCCCTGCAGGG TTCGTTCGCCCTCCGCTGATCATCTTCTCTGTGGACGGTTTCCGCGCATCGTACATGAAG AAAGGCAGCAAGGTCATGCCTAACATCGAAAAGCTGAGGTCTTGTGGCACTCACTCCCCC TACATGAGGCCTGTGTACCCGACGAAAACTTTCCCTAACTTATACACTCTGGCCACTGGG CTGTATCCAGAATCACATGGAATTGTTGGCAATTCCATGTATGATCCTGTTTTTGATGCA CATTTCAACCTTCGAGGGCGAGAGAAATTTAACCATAGGTGGTGGGGAGGTCAACCGCTA TGGATTACAGCCACGAAGCAAGGGGTGATCGCTGGGACATTCTTCTGGCCTGTGGTGATC CCCCACGAGCGGAGAATACTGACCATCCTGCAGTGGCTGACCCTGCCGGACCACGAAAGG CCTTCAGTCTATGCCTTCTATTCCGAACAACCTGATTTCTCTGGACACAAGTATGGCCCC TTTGGCCCTGAGATGACGAATCCTCTGAGGGACATTGACAAAACCGTGGGGCAGTTAATG GATGGATTGAAGCAACTGAAGCTGCACCGCTGCGTGAATGTCATCTTCGTTGGAGACCAT GGAATGGAAGATGTCACATGTGATAGAACAGAATTCTTGAGCAATTACCTGACTAATGTG GATGATATTATTTTAGTGCCAGGAACTCTAGGAAGAATTCGACCCAAATTCAACAATCAT GCTAAATATGACCCGAAAGTCATTATTGCTAATCTCACGTGTAAAAAACCAGACCAGCAC TTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTACGCCAACAACAGAAGG ATCGAAGACGTCCATTTACTGGTGGAGCGCAGATGGCACGTCGCAAGGAAACCTTTGGAG GTTTATAAGAAACCATCAGGAAAATGTTTTTTCCAGGGAGACCACGGATTTGATAACAAG GTCAACAGTATGCAGACTGTTTTTGTAGGTTATGGCCCAACATTTAAGTACAAGACCAAA GTGCCTCCATTTGAAAACATTGAACTTTACAACGTTATGTGCGATCTCCTGGGATTGAAG CCAGCTCCAAATAACGGGACCCACGGGAGTCTGAACCATCTCCTGCGTACCAACACCTTC AGACCGACTGTGCCAGAGGAAGTCACCAGACCCAATTACCCAGGGGTTATGTACCTTCAG TCCGATTTTGACCTGGGCTGTACCTGTGATGATAAGGCAGAGCCAAAGAACAAATTGGAT GAACTCAACAAACACCTTCATATAAAAGAGTCCACAGAAGCTGAAACCAGGAAATTCAGA GGCAGCAAAAATGAAATCAAGGAAAACGTTAATGGAAATTTTGAACCTAGAAAAGAGAGA CATCTCCTCTATGGACGGCCTGCCGTGCTCTATCGGACTAGATATGATATCTTATATCAC ACTGACTTTGAAAGCGGTTATAGTGAAATATTTCTAATGCCACTCTGGACATCATACACT GTTTCCAAACAGGCTGACGTCTCTGACATCCCTGCACACCTGACCAACTGTGTCCGGCCC GACGTCCGCGTTTCTCCGAGTTTCAGTCAGAGCTGTTTGGCCTACAAAAATGATAAACAG ATGTCCTATGGATTCCTCTTTCCTCCCTATCTGAGCTCGTCCCCAGAAGCTAAATATGAT GCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCTTTTAAACGCATCTGGAATTAT TTCCAAAGGGTTCTGGTGAAGAAATATGCTTCAGAAAGAAATGGAGTTAATGTGATAAGT GGACCAATCTTTGACTATGACTACGATGGCTTACACGACACACAAGACAAAATCAAACAG TACGTGGAGGGCAGCTCCGTCCCCGTGCCCACCCACTACTACAGCATCCTCACCAGCTGC CTGGACTTCACGCAGCCTGCCGACCGCTGCGACGGGCCGCTCTCCGTGTCCGCCTTCGTG CTGCCCCACAGGCCCGACAACGACGAGAGCTGCAACAGCTCAGAGGACGAGTCGAAATGG GTGGAAGAGCTTCTCAAGATGCACACAGCACGGGTGCGGGACATCGAGCATCTCACCAGC CTGGACTTCTTCCGCAAGACCAGCCGCAGCTACCCAGAAATTCTGACCCTAAAGACGTAC CTGCAGACGTATGAGAGCGAGATCTAG |
| Protein Properties | |
| Number of Residues | 888 |
| Molecular Weight | 101717.0 |
| Theoretical pI | 7.56 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 MARRRSCQLHQVISLFTFAVGVNICLGVTANRIKRAEGWGEGPPTVLSDSPSINISGSCK GRCFELQEAGPPDCRCDNLCKSYSSCCLDFDELCLKTAGGWECTKDRCGEVRNEDHACHC SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKTPECPAGFVRPPLIIFSVDGFRASYMK KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA HFNLRGREKFNHRWWGGQPLWITATKQGVIAGTFFWPVVIPHERRILTILQWLTLPDHER PSVYAFYSEQPDFSGHKYGPFGPEMTNPLRDIDKTVGQLMDGLKQLKLHRCVNVIFVGDH GMEDVTCDRTEFLSNYLTNVDDIILVPGTLGRIRPKFNNHAKYDPKVIIANLTCKKPDQH FKPYLKQHLPKRLHYANNRRIEDVHLLVERRWHVARKPLEVYKKPSGKCFFQGDHGFDNK VNSMQTVFVGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF RPTVPEEVTRPNYPGVMYLQSDFDLGCTCDDKAEPKNKLDELNKHLHIKESTEAETRKFR GSKNEIKENVNGNFEPRKERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYT VSKQADVSDIPAHLTNCVRPDVRVSPSFSQSCLAYKNDKQMSYGFLFPPYLSSSPEAKYD AFLVTNMVPMYPAFKRIWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTQDKIKQ YVEGSSVPVPTHYYSILTSCLDFTQPADRCDGPLSVSAFVLPHRPDNDESCNSSEDESKW VEELLKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLQTYESEI |
| External Links | |
| GenBank ID Protein | AAI26632.1 |
| UniProtKB/Swiss-Prot ID | A1A4K5 |
| UniProtKB/Swiss-Prot Entry Name | ENPP2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC126631 |
| GeneCard ID | ENPP2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |