Showing Protein G protein-coupled receptor kinase 5 (BMDBP00178)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00178 |
| Secondary Accession Numbers | None |
| Name | G protein-coupled receptor kinase 5 |
| Synonyms | Not Available |
| Gene Name | GRK5 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in ATP binding |
| Specific Function | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors (Beta-2 adrenergic receptor), muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 26 |
| Locus | Not Available |
| SNPs | GRK5 |
| Gene Sequence |
>1773 bp ATGGAGCTGGAAAACATCGTGGCCAACACGGTCTTGCTGAAAGCCAGGGAAGGAGGCGGA GGAAAGCGCAAAGGGAAAAGCAAGAAGTGGAAGGAAATCCTGAAGTTCCCTCACATAAAC CAGTGTGAAGACCTCCGAAGAACCATAGACCGAGATTACTGCAGTTTATGTGACAAACAG CCAGTCGGGAGGCTGCTTTTCCGGCAGTTCTGCGAAACCAGACCTGGGCTGGAGTCCTAC ATTCAGTTCCTGGACTCGGTGGCAGAATATGAAGTTACTCCAGATGAAAAACTGGGAGAA AAAGGGAAGGAAATTATGACCAAGTACCTCACCCCAAAGTCCCCAGTTTTCATCACCCAA GTTGGACGGGACCTGGTCTCCCAGACGGAGGAGAAGCTCCTTCAGAAACCCTGCAAAGAA CTCTTCTCGGCCTGCGTGCAGTCTGTCCACGACTACCTGAGGGGAGAACCCTTCCACGAG TACCTGGACAGCATGTATTTTGATCGCTTTCTCCAGTGGAAGTGGTTGGAAAGGCAACCG GTAACCAAAAACACTTTCAGGCAGTACCGAGTACTAGGAAAAGGGGGCTTTGGGGAGGTC TGTGCCTGCCAGGTTCGGGCCACGGGTAAAATGTACGCCTGCAAACGCTTGGAGAAGAAG AGGATCAAAAAGAGGAAAGGGGAGTCCATGGCCCTGAATGAGAAGCAGATTCTGGAGAAG GTCAACAGTCGGTTTGTGGTCAACCTGGCCTACGCCTACGAGACCAAGGATGCCCTGTGT TTGGTCCTGACCATCATGAACGGCGGGGACCTGAAGTTCCACATTTACAACATGGGGAAC CCCGGCTTCGAGGAGGAGCGCGCCCTGTTCTACGCGGCAGAGATCCTGTGCGGCCTGGAG GACCTCCACCATGAGAACATTGTCTACAGAGATTTGAAACCTGAAAATATCCTGTTAGAC GATTACGGCCACATTAGAATTTCGGACCTGGGCCTGGCCGTGAAGATCCCCGAGGGAGAC CTGATTCGCGGCCGAGTGGGCACCGTTGGCTACATGGCTCCAGAGGTCCTGAACAACCAG AGGTATGGCCTGAGCCCCGACTACTGGGGTCTGGGCTGCCTCATCTACGAGATGATCGAG GGCCAGTCGCCCTTCCGCGGCCGCAAGGAGAAGGTGAAGCGGGAGGAGGTGGACCGCCGG GTGTTGGAGACAGAGGAGGTGTACTCGCACAAGTTCTCCGAGGAGGCCAAGTCCATCTGC AAAATGCTGCTCACCAAAGATGCAAAGCAGAGGCTGGGCTGCCAGGAGGAAGGGGCCGCG GAGGTCAAGAGACACCCCTTCTTCAGGAACATGAATTTCAAGCGCTTAGAGGCCGGGATG TTGGATCCCCCCTTTGTTCCAGATCCCCGGGCCGTGTACTGCAAGGACGTCTTGGACATC GAGCAGTTCTCCACCGTGAAGGGCGTCAACCTGGACCACACGGACGACGACTTCTACTCC AAGTTCTCCACGGGCTCTGTGCCCATCCCGTGGCAAAGCGAGATGATAGAAACAGAGTGC TTTAAGGAGCTGAACGTGTTCGGACCCCACGGTACCCTCTCACCGGACCTGAACCGAAGC CACCCTCCGGAACCGCCAAAGAAAGGGCTGCTCCAGAGGCTCTTCAAGCGTCAGCATCAA AACAATTCCAAGAGTTCACCCAATTCCAAGACCAGTTTTAACCACCACATCAATTCAAAC CACGTGAGTTCAAACTCCACCGGAAGCAGCTAG |
| Protein Properties | |
| Number of Residues | 590 |
| Molecular Weight | 67889.0 |
| Theoretical pI | 8.32 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>G protein-coupled receptor kinase 5 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHINQCEDLRRTIDRDYCSLCDKQ PVGRLLFRQFCETRPGLESYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFITQ VGRDLVSQTEEKLLQKPCKELFSACVQSVHDYLRGEPFHEYLDSMYFDRFLQWKWLERQP VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK VNSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE DLHHENIVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI EQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPHGTLSPDLNRS HPPEPPKKGLLQRLFKRQHQNNSKSSPNSKTSFNHHINSNHVSSNSTGSS |
| External Links | |
| GenBank ID Protein | AAA17561.1 |
| UniProtKB/Swiss-Prot ID | P43249 |
| UniProtKB/Swiss-Prot Entry Name | GRK5_BOVIN |
| PDB IDs | |
| GenBank Gene ID | U01206 |
| GeneCard ID | GRK5 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |