| Identification |
|---|
| BMDB Protein ID
| BMDBP00182 |
| Secondary Accession Numbers
| None |
| Name
| Dynamin-1-like protein |
| Synonyms
|
Not Available
|
| Gene Name
| DNM1L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution (By similarity). Rhythmic control of its activity following phosphorylation at Ser-650 is essential for the circadian control of mitochondrial ATP production (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| DNM1L |
| Gene Sequence
|
>2250 bp
ATGGAGGCGCTAATTCCTGTTATTAACAAACTCCAGGACGTCTTCAACACGGTGGGCGCC
GACATCATCCAGCTGCCTCAGATCGTGGTGGTGGGAACGCAGAGCAGTGGAAAGAGCTCA
GTGCTAGAAAGCCTAGTGGGGAGGGACCTGCTTCCCAGAGGCACTGGTATTGTCACCCGG
AGACCTCTCATTCTGCAGCTAGTCCATGTTGCACCTGAAGATAAACGAAAAACAACAGGA
GAAGAAAATGACCCTGCTACATGGAAAAACTCAAGACACCTTTCTAAAGGGGTTGAAGCA
GAAGAATGGGGTAAATTTCTTCACACCAAAAATAAGCTTTACACAGATTTTGATGAAATT
CGACAAGAAATTGAAAATGAAACAGAAAGGATTTCAGGAAATAATAAGGGAGTAAGCCCT
GAACCAATTCATCTTAAGATTTTTTCACCCAATGTTGTCAATCTGACACTTGTGGATTTG
CCAGGAATGACCAAGGTGCCTGTAGGTGATCAACCTAAAGATATTGAGCTTCAAATCAGA
GAGCTCATCCTTCGGTTCATCAGTAATCCAAATTCCATTATCCTCGCTGTCACTGCTGCT
AATACAGATATGGCAACATCAGAGGCACTTAAAATTTCAAGAGAGGTAGATCCAGATGGT
CGCAGAACCCTAGCTGTAATCACTAAACTTGATCTCATGGATGCAGGTACTGATGCCATG
GATGTATTGATGGGAAGGGTTATACCGGTCAAACTGGGAATAATTGGAGTAGTTAACAGG
AGTCAGCTAGATATTAACAATAAGAAGAGTGTAACTGATTCAATCCGTGATGAATATGCT
TTCCTTCAAAAGAAATACCCATCTCTGGCTAATAGAAATGGAACAAAGTATCTTGCCCGG
ACTTTAAACAGGTTACTGATGCATCACATCAGAGATTGCTTACCAGAGTTGAAAACGAGA
ATAAATGTTCTAGCTGCTCAATATCAGTCTCTTCTAAATAGCTATGGTGAACCTGTGGAT
GATAAAAGTGCTACTTTACTCCAGCTTATTACCAAATTTGCCACAGAATATTGTAATACT
ATTGAAGGAACTGCAAAATATATTGAAACGTCAGAGCTATGTGGTGGTGCTCGAATATGT
TATATTTTCCATGAGACTTTTGGGCGAACCTTAGAATCTGTTGACCCTCTTGGTGGCCTT
AACACTATTGACATTTTGACTGCCATTAGAAATGCAACTGGTCCTCGTCCTGCTTTGTTT
GTGCCTGAAGTTTCATTTGAGTTATTGGTCAAACGGCAGATCAAACGTCTGGAAGAGCCC
AGCCTCCGTTGTGTGGAACTGGTTCATGAAGAAATGCAAAGGATCATTCAACACTGTAGC
AATTACAGTACACAGGAGTTGTTGCGGTTCCCTAAACTTCATGATGCCATAGTTGAAGTA
GTGACTTGTCTTCTTCGTAAACGGTTGCCTGTTACAAATGAAATGGTCCATAACTTAGTG
GCAATTGAATTGGCTTATATCAACACAAAACATCCAGACTTTGCTGATGCTTGTGGGTTA
ATGAACAACAATATAGAGGAACAAAGGAGAAACAGGCTAGCAAGAGAATTGCCTTCAGCT
GTATCACGAGACAAGTCTTCTAAAGTTCCAAGTGCTTTGGCACCTGCCTCCCAGGAGCCC
TCCCCTGCTGCTTCTGCTGAGGCTGATGGCAAGTTAATTCAGGAGAGCAGAAGAGAAACT
AAAAATGCTGCATCTGGAGGTGGTGGGGTTGGAGATGCTGTTCAAGAACCAACAACAGGC
AACTGGAGAGGAATGCTGAAAACTTCAAAAGCTGAGGAGTTACTAGCTGAGGAAAAATCA
AAACCAATTCCAATTATGCCAGCCAGTCCACAAAAAGGCCACGCTGTGAATTTGCTGGAT
GTGCCAGTTCCTGTTGCACGAAAACTATCTGCCCGTGAACAGCGAGACTGTGAAGTTATT
GAACGACTCATCAAATCATATTTTCTTATTGTCAGAAAGAATATTCAAGACAGTGTGCCA
AAGGCAGTAATGCATTTTTTGGTTAATCATGTGAAAGATACTCTTCAGAGTGAGTTAGTA
GGACAGCTATATAAATCATCCTTACTGGATGATCTTCTGACTGAATCCGAGGACATGGCA
CAGCGTAGGAAAGAAGCAGCTGATATGCTAAAGGCATTACAAGGAGCCAGTCAAATTATT
GCTGAAATCCGAGAGACTCATCTTTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 749 |
| Molecular Weight
| 83352.0 |
| Theoretical pI
| 7.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dynamin-1-like protein
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTR
RPLILQLVHVAPEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEI
RQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIR
ELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAM
DVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLAR
TLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNT
IEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALF
VPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEV
VTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSA
VSRDKSSKVPSALAPASQEPSPAASAEADGKLIQESRRETKNAASGGGGVGDAVQEPTTG
NWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVI
ERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMA
QRRKEAADMLKALQGASQIIAEIRETHLW
|
| External Links |
|---|
| GenBank ID Protein
| AAI12711.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIA5 |
| UniProtKB/Swiss-Prot Entry Name
| DNM1L_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112710 |
| GeneCard ID
| DNM1L |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
