Identification
BMDB Protein ID BMDBP00185
Secondary Accession Numbers None
Name Activated CDC42 kinase 1
Synonyms Not Available
Gene Name TNK2
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus Not Available
SNPs TNK2
Gene Sequence
>2244 bp
ATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTAGAGCTGCTGTCCGAGGTGCAGCTCCAG
CAGTATTTCCTGCGCCTCCGCGACGACCTCAACGTCACCCGCCTGTCCCACTTTGAGTAT
GTCAAGAACGAGGACCTGGAGAAGATCGGCATGGGCCGGCCCGGCCAGCGGCGGCTATGG
GAGGCCGTGAAGAGGAGGAAGGCCATGTGCAAACGCAAGTCCTGGATGAGCAAGGTGTTC
AGTGGAAAGCGGCTGGAGGCTGAGTTCCCCCCTCATCACTCTCAGAGCACCTTCCGGAAG
ACCTCGCCCACCCCAGGGGGCTCTGCTGGGGAGGGGTCCCTGCAGAGCCTCACCTGCCTC
ATTGGGGAGAAGGACCTGCATCTCTTCGAGAAGCTGGGAGATGGCTCCTTTGGCGTGGTG
CGCAGGGGCGAGTGGGACGCCCCCTCGGGGAAGACGGTGAGCGTGGCTGTGAAGTGCCTG
AAGCCCGACGTGCTGAGCCAGCCGGAGGCCATGGACGACTTCATCCGGGAGGTCAACGCC
ATGCACTCGCTTGACCACCGAAACCTCATTCGCCTCTACGGGGTGGTGCTCACACCGCCC
ATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCATTGTTGGACCGGCTGCGCAAGCAC
CAGGGCCACTTCCTGCTGGGCACCCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATG
GGCTACCTGGAGGCCAAGCGCTTCATCCACCGGGACCTGGCCGCCCGAAATCTGCTGTTG
GCCACCCGCGACCTGGTCAAGATAGGGGACTTCGGGCTGATGCGAGCACTGCCCCAGAAC
GACGACCACTACGTCATGCAGGAACATCGCAAGGTGCCCTTTGCCTGGTGTGCCCCAGAG
AGCCTGAAGACACGCACCTTCTCCCACGCCAGCGACACCTGGATGTTTGGGGTCACGCTG
TGGGAGATGTTCACCTATGGCCAGGAGCCCTGGATTGGCCTCAATGGCAGTCAGATCCTG
CATAAGATTGACAAGGAGGGGGAGCGTCTACCCCGGCCGGAGGACTGCCCCCAGGACATC
TACAATGTCATGGTCCAGTGCTGGGCTCACAAGCCCGAGGACAGACCCACGTTTGTGGCC
CTGCGGGACTTCCTGCTGGAGGCTCAGCCCACCGACATGCGGGCCCTTCAGGACTTCGAA
GAACCTGACAAGCTGCACATCCAGATGAATGATGTCATCACCGTCATCGAGGGGAGGGCT
GAGAATTACTGGTGGCGTGGGCAGAACACGCGGACGCTGTGCGTGGGGCCCTTCCCTCGC
AACGTGGTGACCTCCGTGGCTGGTCTGTCAGCCCAGGACATCAGCCAGCCACTGCAGAAT
AGCTTCATCCACACGGGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCTGAC
AAGATTGATGAACTGTATCTGGGAAACCCCATGGACCCTCCTGACCTGCTGAGCGTGGAA
CTGAGCACATCCAGGCCCACCCAGCATCTGGGCAGGGTGAAAAGGGAGCCTCCACCTCGC
CCTCCTCAGCCTGCCATCTTCACTCAGAAACCAACCTACGACCCCGTGAGTGAGGACCAA
GACCCCCTGTCCAGCGACTTCAAGAAGCTGGGCCTGCGAAAGCCAGGACTGCCCCGTGGG
CTGTGGCTCGCGAAGCCCTCAGCCCGGGTGCCAGGCACCAAGGCCGGCCGCGGTGGTGGC
GAGGTCACGCTCATCGATTTCGGCGAGGAGCCTGTTGTGCCGGCCCCACGGCCCTGTGCC
CCATCACTGGCGCAGCTGGCCATGGACGCCTGTTCCTTGCTGGACAAGACCCCGCCACAG
AGCCCTACACGGGCCCTGCCCCGGCCCCTGCATCCCACGCCTGTGGTGGACTGGGATGCA
CGCCCACTGCCCCCGCCTCCCGCCTACGATGACGTGGCCCAGGATGAGGATGACTTCGAG
GTCTGCTCCATCAACAGCACCCTCGTGGGCGCCGGGGTCTCTGCTGAGCCCAGCCAGGGC
GAGACCAACTATGCCTTTGTGCCTGAGCCGGCGAGGCTCCTCCCCCCCGCTGGAGGACAA
CCTGTTCCTCCCACCCCAGAGTGGGGGCAAGCCACCCAACTCGGCCCAAACCGCAGAGAT
CTTCCAGGCGCTGCAGCAGGAATGCATGCGGCAGCTACAGGTCCCGCCTGGCTCTCTGGT
CCCCTCACCCAGCCCTGGGGGTGA
Protein Properties
Number of Residues 1039
Molecular Weight 114868.0
Theoretical pI 7.38
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Activated CDC42 kinase 1
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKAMCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPTPGGSAGEGSLQSLTCL
IGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKTVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLEAKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
KIDELYLGNPMDPPDLLSVELSTSRPTQHLGRVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKAGRGGGEVTLIDFGEEPVVPAPRPCAPSLAQLAMDACSLLD
KTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVGAGVSA
EPSQGETNYAFVPEPARLLPPLEDNLFLPPQSGGKPPNSAQTAEIFQALQQECMRQLQVP
PGSLVPSPSPGGDDKPQVPPRVPIPPRPTRSRGELSPVPPGEEEMGRWPGPASPPRVPPR
EPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG
PCILPIVRDGKKVSSTHYYLLPERPPYLERYQRFLHEAQSPRGPDPTPIPLLLPPPSTPA
PAAPTATVRPMPQAAPDPKANFSSNNSNPGARPSSLRATARLPQRGYPGDGPEAGRPADK
IQMLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRGECHNVLEMFDWN
LEQAGCHLLGSCGPAHHKR
GenBank ID Protein AAC05310.1
UniProtKB/Swiss-Prot ID Q17R13
UniProtKB/Swiss-Prot Entry Name ACK1_BOVIN
PDB IDs
GenBank Gene ID U96722
GeneCard ID TNK2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available