| Identification |
|---|
| BMDB Protein ID
| BMDBP00185 |
| Secondary Accession Numbers
| None |
| Name
| Activated CDC42 kinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| TNK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| TNK2 |
| Gene Sequence
|
>2244 bp
ATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTAGAGCTGCTGTCCGAGGTGCAGCTCCAG
CAGTATTTCCTGCGCCTCCGCGACGACCTCAACGTCACCCGCCTGTCCCACTTTGAGTAT
GTCAAGAACGAGGACCTGGAGAAGATCGGCATGGGCCGGCCCGGCCAGCGGCGGCTATGG
GAGGCCGTGAAGAGGAGGAAGGCCATGTGCAAACGCAAGTCCTGGATGAGCAAGGTGTTC
AGTGGAAAGCGGCTGGAGGCTGAGTTCCCCCCTCATCACTCTCAGAGCACCTTCCGGAAG
ACCTCGCCCACCCCAGGGGGCTCTGCTGGGGAGGGGTCCCTGCAGAGCCTCACCTGCCTC
ATTGGGGAGAAGGACCTGCATCTCTTCGAGAAGCTGGGAGATGGCTCCTTTGGCGTGGTG
CGCAGGGGCGAGTGGGACGCCCCCTCGGGGAAGACGGTGAGCGTGGCTGTGAAGTGCCTG
AAGCCCGACGTGCTGAGCCAGCCGGAGGCCATGGACGACTTCATCCGGGAGGTCAACGCC
ATGCACTCGCTTGACCACCGAAACCTCATTCGCCTCTACGGGGTGGTGCTCACACCGCCC
ATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCATTGTTGGACCGGCTGCGCAAGCAC
CAGGGCCACTTCCTGCTGGGCACCCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATG
GGCTACCTGGAGGCCAAGCGCTTCATCCACCGGGACCTGGCCGCCCGAAATCTGCTGTTG
GCCACCCGCGACCTGGTCAAGATAGGGGACTTCGGGCTGATGCGAGCACTGCCCCAGAAC
GACGACCACTACGTCATGCAGGAACATCGCAAGGTGCCCTTTGCCTGGTGTGCCCCAGAG
AGCCTGAAGACACGCACCTTCTCCCACGCCAGCGACACCTGGATGTTTGGGGTCACGCTG
TGGGAGATGTTCACCTATGGCCAGGAGCCCTGGATTGGCCTCAATGGCAGTCAGATCCTG
CATAAGATTGACAAGGAGGGGGAGCGTCTACCCCGGCCGGAGGACTGCCCCCAGGACATC
TACAATGTCATGGTCCAGTGCTGGGCTCACAAGCCCGAGGACAGACCCACGTTTGTGGCC
CTGCGGGACTTCCTGCTGGAGGCTCAGCCCACCGACATGCGGGCCCTTCAGGACTTCGAA
GAACCTGACAAGCTGCACATCCAGATGAATGATGTCATCACCGTCATCGAGGGGAGGGCT
GAGAATTACTGGTGGCGTGGGCAGAACACGCGGACGCTGTGCGTGGGGCCCTTCCCTCGC
AACGTGGTGACCTCCGTGGCTGGTCTGTCAGCCCAGGACATCAGCCAGCCACTGCAGAAT
AGCTTCATCCACACGGGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCTGAC
AAGATTGATGAACTGTATCTGGGAAACCCCATGGACCCTCCTGACCTGCTGAGCGTGGAA
CTGAGCACATCCAGGCCCACCCAGCATCTGGGCAGGGTGAAAAGGGAGCCTCCACCTCGC
CCTCCTCAGCCTGCCATCTTCACTCAGAAACCAACCTACGACCCCGTGAGTGAGGACCAA
GACCCCCTGTCCAGCGACTTCAAGAAGCTGGGCCTGCGAAAGCCAGGACTGCCCCGTGGG
CTGTGGCTCGCGAAGCCCTCAGCCCGGGTGCCAGGCACCAAGGCCGGCCGCGGTGGTGGC
GAGGTCACGCTCATCGATTTCGGCGAGGAGCCTGTTGTGCCGGCCCCACGGCCCTGTGCC
CCATCACTGGCGCAGCTGGCCATGGACGCCTGTTCCTTGCTGGACAAGACCCCGCCACAG
AGCCCTACACGGGCCCTGCCCCGGCCCCTGCATCCCACGCCTGTGGTGGACTGGGATGCA
CGCCCACTGCCCCCGCCTCCCGCCTACGATGACGTGGCCCAGGATGAGGATGACTTCGAG
GTCTGCTCCATCAACAGCACCCTCGTGGGCGCCGGGGTCTCTGCTGAGCCCAGCCAGGGC
GAGACCAACTATGCCTTTGTGCCTGAGCCGGCGAGGCTCCTCCCCCCCGCTGGAGGACAA
CCTGTTCCTCCCACCCCAGAGTGGGGGCAAGCCACCCAACTCGGCCCAAACCGCAGAGAT
CTTCCAGGCGCTGCAGCAGGAATGCATGCGGCAGCTACAGGTCCCGCCTGGCTCTCTGGT
CCCCTCACCCAGCCCTGGGGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1039 |
| Molecular Weight
| 114868.0 |
| Theoretical pI
| 7.38 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Activated CDC42 kinase 1
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKAMCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPTPGGSAGEGSLQSLTCL
IGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKTVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLEAKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
KIDELYLGNPMDPPDLLSVELSTSRPTQHLGRVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKAGRGGGEVTLIDFGEEPVVPAPRPCAPSLAQLAMDACSLLD
KTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVGAGVSA
EPSQGETNYAFVPEPARLLPPLEDNLFLPPQSGGKPPNSAQTAEIFQALQQECMRQLQVP
PGSLVPSPSPGGDDKPQVPPRVPIPPRPTRSRGELSPVPPGEEEMGRWPGPASPPRVPPR
EPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG
PCILPIVRDGKKVSSTHYYLLPERPPYLERYQRFLHEAQSPRGPDPTPIPLLLPPPSTPA
PAAPTATVRPMPQAAPDPKANFSSNNSNPGARPSSLRATARLPQRGYPGDGPEAGRPADK
IQMLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRGECHNVLEMFDWN
LEQAGCHLLGSCGPAHHKR
|
| External Links |
|---|
| GenBank ID Protein
| AAC05310.1 |
| UniProtKB/Swiss-Prot ID
| Q17R13 |
| UniProtKB/Swiss-Prot Entry Name
| ACK1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U96722 |
| GeneCard ID
| TNK2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
