Showing Protein Activated CDC42 kinase 1 (BMDBP00185)
Identification | |
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BMDB Protein ID | BMDBP00185 |
Secondary Accession Numbers | None |
Name | Activated CDC42 kinase 1 |
Synonyms | Not Available |
Gene Name | TNK2 |
Protein Type | Enzyme |
Biological Properties | |
General Function | Involved in ATP binding |
Specific Function | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity). |
Pathways | Not Available |
Reactions | Not Available |
GO Classification | Not Available |
Cellular Location | Not Available |
Gene Properties | |
Chromosome Location | 1 |
Locus | Not Available |
SNPs | TNK2 |
Gene Sequence |
>2244 bp ATGCAGCCAGAGGAGGGCACAGGCTGGCTGCTAGAGCTGCTGTCCGAGGTGCAGCTCCAG CAGTATTTCCTGCGCCTCCGCGACGACCTCAACGTCACCCGCCTGTCCCACTTTGAGTAT GTCAAGAACGAGGACCTGGAGAAGATCGGCATGGGCCGGCCCGGCCAGCGGCGGCTATGG GAGGCCGTGAAGAGGAGGAAGGCCATGTGCAAACGCAAGTCCTGGATGAGCAAGGTGTTC AGTGGAAAGCGGCTGGAGGCTGAGTTCCCCCCTCATCACTCTCAGAGCACCTTCCGGAAG ACCTCGCCCACCCCAGGGGGCTCTGCTGGGGAGGGGTCCCTGCAGAGCCTCACCTGCCTC ATTGGGGAGAAGGACCTGCATCTCTTCGAGAAGCTGGGAGATGGCTCCTTTGGCGTGGTG CGCAGGGGCGAGTGGGACGCCCCCTCGGGGAAGACGGTGAGCGTGGCTGTGAAGTGCCTG AAGCCCGACGTGCTGAGCCAGCCGGAGGCCATGGACGACTTCATCCGGGAGGTCAACGCC ATGCACTCGCTTGACCACCGAAACCTCATTCGCCTCTACGGGGTGGTGCTCACACCGCCC ATGAAGATGGTGACAGAGCTGGCACCTCTGGGATCATTGTTGGACCGGCTGCGCAAGCAC CAGGGCCACTTCCTGCTGGGCACCCTGAGCCGCTACGCTGTGCAGGTGGCTGAGGGCATG GGCTACCTGGAGGCCAAGCGCTTCATCCACCGGGACCTGGCCGCCCGAAATCTGCTGTTG GCCACCCGCGACCTGGTCAAGATAGGGGACTTCGGGCTGATGCGAGCACTGCCCCAGAAC GACGACCACTACGTCATGCAGGAACATCGCAAGGTGCCCTTTGCCTGGTGTGCCCCAGAG AGCCTGAAGACACGCACCTTCTCCCACGCCAGCGACACCTGGATGTTTGGGGTCACGCTG TGGGAGATGTTCACCTATGGCCAGGAGCCCTGGATTGGCCTCAATGGCAGTCAGATCCTG CATAAGATTGACAAGGAGGGGGAGCGTCTACCCCGGCCGGAGGACTGCCCCCAGGACATC TACAATGTCATGGTCCAGTGCTGGGCTCACAAGCCCGAGGACAGACCCACGTTTGTGGCC CTGCGGGACTTCCTGCTGGAGGCTCAGCCCACCGACATGCGGGCCCTTCAGGACTTCGAA GAACCTGACAAGCTGCACATCCAGATGAATGATGTCATCACCGTCATCGAGGGGAGGGCT GAGAATTACTGGTGGCGTGGGCAGAACACGCGGACGCTGTGCGTGGGGCCCTTCCCTCGC AACGTGGTGACCTCCGTGGCTGGTCTGTCAGCCCAGGACATCAGCCAGCCACTGCAGAAT AGCTTCATCCACACGGGGCATGGCGACAGTGACCCCCGCCACTGCTGGGGCTTCCCTGAC AAGATTGATGAACTGTATCTGGGAAACCCCATGGACCCTCCTGACCTGCTGAGCGTGGAA CTGAGCACATCCAGGCCCACCCAGCATCTGGGCAGGGTGAAAAGGGAGCCTCCACCTCGC CCTCCTCAGCCTGCCATCTTCACTCAGAAACCAACCTACGACCCCGTGAGTGAGGACCAA GACCCCCTGTCCAGCGACTTCAAGAAGCTGGGCCTGCGAAAGCCAGGACTGCCCCGTGGG CTGTGGCTCGCGAAGCCCTCAGCCCGGGTGCCAGGCACCAAGGCCGGCCGCGGTGGTGGC GAGGTCACGCTCATCGATTTCGGCGAGGAGCCTGTTGTGCCGGCCCCACGGCCCTGTGCC CCATCACTGGCGCAGCTGGCCATGGACGCCTGTTCCTTGCTGGACAAGACCCCGCCACAG AGCCCTACACGGGCCCTGCCCCGGCCCCTGCATCCCACGCCTGTGGTGGACTGGGATGCA CGCCCACTGCCCCCGCCTCCCGCCTACGATGACGTGGCCCAGGATGAGGATGACTTCGAG GTCTGCTCCATCAACAGCACCCTCGTGGGCGCCGGGGTCTCTGCTGAGCCCAGCCAGGGC GAGACCAACTATGCCTTTGTGCCTGAGCCGGCGAGGCTCCTCCCCCCCGCTGGAGGACAA CCTGTTCCTCCCACCCCAGAGTGGGGGCAAGCCACCCAACTCGGCCCAAACCGCAGAGAT CTTCCAGGCGCTGCAGCAGGAATGCATGCGGCAGCTACAGGTCCCGCCTGGCTCTCTGGT CCCCTCACCCAGCCCTGGGGGTGA |
Protein Properties | |
Number of Residues | 1039 |
Molecular Weight | 114868.0 |
Theoretical pI | 7.38 |
Pfam Domain Function | Not Available |
Signals |
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Transmembrane Regions | Not Available |
Protein Sequence |
>Activated CDC42 kinase 1 MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW EAVKRRKAMCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPTPGGSAGEGSLQSLTCL IGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA MHSLDHRNLIRLYGVVLTPPMKTVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM GYLEAKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD KIDELYLGNPMDPPDLLSVELSTSRPTQHLGRVKKPTYDPVSEDQDPLSSDFKRLGLRKP GLPRGLWLAKPSARVPGTKAGRGGGEVTLIDFGEEPVVPAPRPCAPSLAQLAMDACSLLD KTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVGAGVSA EPSQGETNYAFVPEPARLLPPLEDNLFLPPQSGGKPPNSAQTAEIFQALQQECMRQLQVP PGSLVPSPSPGGDDKPQVPPRVPIPPRPTRSRGELSPVPPGEEEMGRWPGPASPPRVPPR EPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG PCILPIVRDGKKVSSTHYYLLPERPPYLERYQRFLHEAQSPRGPDPTPIPLLLPPPSTPA PAAPTATVRPMPQAAPDPKANFSSNNSNPGARPSSLRATARLPQRGYPGDGPEAGRPADK IQMLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRGECHNVLEMFDWN LEQAGCHLLGSCGPAHHKR |
External Links | |
GenBank ID Protein | AAC05310.1 |
UniProtKB/Swiss-Prot ID | Q17R13 |
UniProtKB/Swiss-Prot Entry Name | ACK1_BOVIN |
PDB IDs | |
GenBank Gene ID | U96722 |
GeneCard ID | TNK2 |
GenAtlas ID | Not Available |
HGNC ID | Not Available |
References | |
General References | Not Available |