Showing Protein Eyes absent homolog 2 (BMDBP00194)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00194 |
| Secondary Accession Numbers | None |
| Name | Eyes absent homolog 2 |
| Synonyms | Not Available |
| Gene Name | EYA2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in magnesium ion binding |
| Specific Function | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 13 |
| Locus | Not Available |
| SNPs | EYA2 |
| Gene Sequence |
>1614 bp ATGCTAGAACTACTGGTCTCAGCCAGCCTTACTGTAAACAGTGATCGTCCGGGTAAACTG AAGCCTAGCCGTGCTGATGCTGATGTCTGGACTCTGAGTGACAGAGAAGGCATCACCACA TCGGCTCGGAGTGTGTCCCAGCTCTTTGCAAGACCTTGCCCGCGTGTCCCACCTGGTCAG CCTCCCTCGGCCATGGCAGCCTACAGCCAGACACAGTACAGTGCAGGGATCCAGCAAGCT ACCCCCTACACGGCTTACCCGCCTCCAGCACAAGCCTATGGAATCCCTTCTTACAGCATC AAGACAGAAGACAGCTTGAACCATTCCCCCGGCCAGAGTGGCTTCCTCAGCTATGGCTCC AGCTTCAGCACCCCAGCCTCTGGACAGAGCCCGTACACCTACCAGATGCATGGCACGGCC GGGATCTATCAAGGAGCAAATGGACTGACCAACGCGGCCGGATTCGGAACTGTGCACCAG GACTATCCTTCCTACCCCGGCTTCCCGCAGAGCCAGTACTCCCAGTATTACAGCTCGTCC TACAACCCTCCTTACGTCCCAGCCAGCAGCATCTGCCCTTCTCCTCTCTCCACGTCCACC TACGTCCTCCAAGAGGCATCTCACAACATCCCCAGCCAGAGTTCCGAGTCGCTTGGCGGT GAATATAACACACACAATGGACCTTCCACACCGGCAAAGGAGGGAGACACAGACAGGCCA CCCCGGGCCTCCGACGGGAAGCTCCGAGGCCGGTCTAAGCGGAGCAGCGACCCCTCCCCA GCAGGGGACAATGAGATCGAGCGTGTGTTCGTGTGGGACCTGGATGAGACGATAATTATT TTCCACTCCTTACTCACGGGGACTTTCGCCTCCAGGTACGGGAAGGACACCACGGCGTCC GTGCGCATCGGCCTCATGATGGAGGAAATGATCTTCAACCTCGCAGACACACATCTGTTC TTCAATGACCTGGAGGATTGTGACCAGATCCACGTGGACGATGTCTCATCTGATGACAAT GGGCAAGATTTAAGCACCTACAACTTCTCCGCCGATGGCTTCCACAGTTCGGCCCCGGGA GCCAACCTGTGCCTGGGCTCCGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCTGGCC TTCCGCTACCGGCGGGTGAAGGAGATGTACAACACCTACAAGAACAACGTCGGCGGCTTG ATAGGAGCTCCCAAAAGAGAGACCTGGCTACAGCTCAGAGCCGAGCTGGAAGCTCTGACT GACCTCTGGCTGACCCACTCTCTGAAGGCACTAAACCTCATCAATTCCCGGCCCAATTGT GTCAACGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTGTAC GGATTGGGTTCTGTGTTTCCTATTGAGAACATCTACAGTGCAACCAAGACAGGGAAGGAG AGCTGCTTCGAGAGGATAATGCAGAGGTTTGGCAGAAAGGCCGTCTACATCGTGATCGGC GATGGAGTGGAAGAGGAGCAGGGAGCCAAAAAGCACAACATGCCTTTCTGGAGGATATCC TGCCACGCAGACCTGGAGGCGCTGAGGCACGCCCTGGAGCTGGAGTATTTATAG |
| Protein Properties | |
| Number of Residues | 537 |
| Molecular Weight | 58807.0 |
| Theoretical pI | 6.15 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Eyes absent homolog 2 MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQ PPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGS SFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSS YNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRP PRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTAS VRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPG ANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALT DLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKE SCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL |
| External Links | |
| GenBank ID Protein | AAX46528.1 |
| UniProtKB/Swiss-Prot ID | Q58DB6 |
| UniProtKB/Swiss-Prot Entry Name | EYA2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT021681 |
| GeneCard ID | EYA2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |