| Identification |
|---|
| BMDB Protein ID
| BMDBP00203 |
| Secondary Accession Numbers
| None |
| Name
| Tyrosine-protein kinase CSK |
| Synonyms
|
Not Available
|
| Gene Name
| CSK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| CSK |
| Gene Sequence
|
>1353 bp
ATGTCAGCAATTCAGGCTGCCTGGCCATCCGGTACAGAATGTATTGCCAAGTACAACTTT
CACGGCACTGCTGAGCAAGACCTTCCCTTCTGCAAAGGAGATGTGCTCACCATTGTGGCT
GTCACCAAGGACCCCAATTGGTACAAAGCCAAGAACAAGGTGGGCCGTGAGGGCATCATC
CCAGCCAACTATGTCCAGAAGCGGGAGGGTGTGAAGGCAGGCACCAAGCTCAGCCTCATG
CCCTGGTTCCATGGCAAGATCACGCGGGAACAGGCAGAGCGGCTCCTGTGCCCACCGGAG
ACAGGCCTGTTCCTGGTGCGGGAGAGCACCAACTACCCCGGGGACTACACGCTGTGCGTG
AGCTGTGATGGCAAGGTGGAGCATTACCGCATCATGTACCACGCCAGCAAGCTCAGCATC
GATGAAGAGGTGTACTTTGAGAACCTCATGCAGCTGGTGGAGCACTACACCTCAGATGCA
GATGGCCTCTGTACTCGCCTCATCAAGCCAAAGGTCATGGAGGGCACCGTGGCCGCCCAG
GATGAGTTCTTCCGCAGTGGCTGGGCGCTGAACATGAAGGACCTGAAGCTGCTGCAGACC
ATAGGGAAGGGGGAGTTTGGAGACGTGATGCTGGGTGACTACCGAGGGAACAAAGTCGCT
GTCAAGTGCATTAAGAACGATGCCACTGCACAGGCCTTCCTGGCTGAAGCCTCCGTCATG
ACGCAACTCCGGCATAGCAACCTGGTACAGCTTCTGGGCGTGATCGTAGAGGAGAAGAGC
GGGCTGTACATCGTTACCGAGTACATGGCCAAGGGGAGTCTAGTGGACTACCTGCGGTCT
CGGGGTCGGTCGGTGCTTGGCGGAGACTGTCTCCTCAAGTTCTCACTAGACGTCTGTGAG
GCCATGGAATACCTGGAGGGCAACAACTTCGTGCATCGGGATCTGGCTGCCCGCAACGTG
CTGGTGTCTGAGGACAATGTGGCCAAGGTCAGCGACTTCGGCCTCACCAAGGAGGCCTCC
AGCACCCAGGACACGGGCAAGCTGCCGGTCAAGTGGACAGCCCCCGAGGCCCTAAGAGAG
AAGAAATTCTCCACCAAGTCTGATGTGTGGAGTTTCGGGATCCTTCTCTGGGAAATCTAC
TCTTTCGGGCGAGTGCCTTATCCAAGAATTCCCCTGAAGGACGTCGTCCCGCGGGTGGAG
AAGGGCTACAAGATGGATGCCCCTGACGGCTGCCCACCTGCAGTCTACGAGGTCATGAAG
AACTGCTGGCACCTGGATGCCGCCACGCGGCCCTCCTTCCTGCAGCTCCGCGAGCAGCTC
GAGCGCATCAAGACCCACGAGCTGCACCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 450 |
| Molecular Weight
| 50633.0 |
| Theoretical pI
| 7.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tyrosine-protein kinase CSK
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLCPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFFRSGWALNMKDLKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
NCWHLDAATRPSFLQLREQLERIKTHELHL
|
| External Links |
|---|
| GenBank ID Protein
| AAI20438.1 |
| UniProtKB/Swiss-Prot ID
| Q0VBZ0 |
| UniProtKB/Swiss-Prot Entry Name
| CSK_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC120437 |
| GeneCard ID
| CSK |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
