Showing Protein Dual specificity protein phosphatase 6 (BMDBP00206)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00206 |
| Secondary Accession Numbers | None |
| Name | Dual specificity protein phosphatase 6 |
| Synonyms | Not Available |
| Gene Name | DUSP6 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 5 |
| Locus | Not Available |
| SNPs | DUSP6 |
| Gene Sequence |
>1146 bp ATGATAGATACGCTCAGACCCGTGCCCTTCGCGTCGGAAATGGCGATCAGCAAGACGGTG GCGTGGCTCAACGAGCAGCTGGAGCTGGGCAACGAGCGGCTGCTGTTGATGGACTGCCGG CCGCAGGAGCTGTACGAGTCGTCCCACATCGAGTCCGCCATCAACGTGGCCATTCCAGGG ATCATGCTGCGGCGCCTGCAGAAGGGCAGCCTGCCGGTGCGCGCGCTATTCACGCGCGGC GAGGACCGGGACCGCTTCACCCGGCGCTGCGGCACCGATACCGTGGTGCTCTACGATGAG AGCAGCAGCGACTGGAACGAGAATACGGGCGGCGAGTCGGTGCTCGGGCTGCTGCTCAAG AAGCTCAAGGACGAGGGATGCCGGGCGTTCTACCTGGAAGGTGGTTTCAGTAAGTTCCAA GCCGAGTTCGCCCTGCACTGCGAGACCAATCTAGACGGCTCGTGTAGCAGCAGCTCGCCA CCGTTGCCAGTGCTGGGGCTCGGGGGCCTGCGGATCAGCTCCGACTCCTCCTCGGACATT GAGTCTGACCTTGACCGAGACCCCAATAGTGCAACGGACTCGGATGGCAGCCCGCTGTCC AACAGTCAGCCTTCTTTCCCTGTGGAGATCTTGCCCTTCCTCTATTTGGGCTGTGCCAAG GACTCCACCAACCTGGACGTGTTGGAGGAGTTTGGCATCAAGTACATATTGAACGTCACC CCCAACTTGCCGAATCTCTTTGAGAATGCAGGAGAGTTCAAATACAAGCAGATCCCCATC TCGGATCACTGGAGCCAAAACCTGTCCCAGTTTTTCCCTGAGGCCATTTCTTTCATAGAT GAAGCCCGGGGCAAAAACTGTGGCGTCCTGGTGCATTGCTTAGCTGGCATCAGCCGCTCG GTCACTGTGACTGTGGCTTACCTTATGCAGAAGCTCAATCTGTCGATGAACGATGCTTAT GACATTGTGAAGATGAAGAAATCCAACATCTCCCCCAACTTCAACTTCATGGGCCAGCTG CTGGACTTCGAGAGGACGCTGGGACTGAGCAGCCCCTGTGACAACCGCGTCCCCACACAG CAGCTCTATTTCACCACCCCCTCCAACCAGAATGTCTACCAGGTGGACTCTCTGCAATCC ACGTGA |
| Protein Properties | |
| Number of Residues | 381 |
| Molecular Weight | 42307.0 |
| Theoretical pI | 4.5 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Dual specificity protein phosphatase 6 MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPG IMLRRLQKGSLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLK KLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDI ESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVT PNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRS VTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPTQ QLYFTTPSNQNVYQVDSLQST |
| External Links | |
| GenBank ID Protein | ABF57380.1 |
| UniProtKB/Swiss-Prot ID | Q2KJ36 |
| UniProtKB/Swiss-Prot Entry Name | DUS6_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BT025424 |
| GeneCard ID | DUSP6 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |