| Identification |
|---|
| BMDB Protein ID
| BMDBP00207 |
| Secondary Accession Numbers
| None |
| Name
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP2A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:22387132). Contributes to calcium sequestration involved in muscular excitation/contraction. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| ATP2A1 |
| Gene Sequence
|
>2982 bp
ATGGAGGCTGCGCACTCCAAGACCACAGAAGAATGTTTGGCCTATTTTGGGGTGAGCGAA
ACTACAGGCCTCACCCCGGACCAAGTTAAGCGGCATCTGGAGAAATATGGCCATAATGAG
CTCCCTGCTGAGGAGGGGAAGTCCCTGTGGGAGCTGGTGTTAGAGCAGTTTGAAGACCTC
CTGGTGCGGATCCTTCTCCTGGCCGCCTGCATTTCCTTTGTGCTGGCCTGGTTTGAGGAA
GGCGAAGAGACTGTCACCGCCTTTGTTGAACCCTTTGTCATCCTCTTGATCCTCATTGCC
AATGCCATCGTGGGGGTTTGGCAGGAGCGGAATGCAGAGAATGCCATCGAGGCTCTGAAG
GAATATGAACCCGAGATGGGGAAGGTCTACCGGGCTGACCGCAAGTCAGTACAAAGGATC
AAAGCTCGGGATATTGTTCCTGGAGACATCGTGGAGGTGGCTGTGGGGGACAAGGTCCCG
GCAGATATCCGCATCCTCACCATCAAGTCTACCACCCTCCGGGTCGACCAGTCCATCCTG
ACAGGCGAGTCTGTCTCTGTCATCAAGCACACAGAACCTGTTCCCGACCCCCGAGCTGTC
AACCAGGATAAGAAGAACATGCTTTTCTCGGGCACCAACATCGCAGCCGGCAAGGCCATC
GGCATTGTGGCCACCACCGGTGTGGGCACCGAGATTGGGAAGATCCGTGACCAAATGGCC
GCCACAGAGCAGGACAAGACCCCTCTGCAGCAAAAGCTGGATGAGTTTGGGGAGCAGCTC
TCCAAGGTCATCTCCCTCATCTGCGTGGCCGTCTGGCTCATCAACATTGGCCACTTCAAC
GACCCCGTGCATGGGGGCTCCTGGATCCGTGGTGCCATCTACTACTTTAAGATCGCCGTG
GCCCTGGCTGTGGCTGCCATCCCCGAGGGCCTTCCTGCAGTCATCACCACCTGCCTGGCC
TTGGGCACCCGCCGGATGGCAAAGAAGAACGCGATCGTGAGGAGCCTGCCCTCCGTGGAG
ACTCTGGGCTGCACCTCTGTCATCTGTTCCGACAAGACGGGCACCCTCACCACCAACCAG
ATGTCTGTCTGCAAGATGTTCATCATCGACAGGATAGATGGGGACCTCTGCCTGCTGAAC
GAGTTCTCTGTCACTGGCTCCACTTACGCTCCTGAAGGAGAGGTCTTGAAGAATGATAAG
CCAGTCCGCTCAGGGCAGTATGACGGGCTGGTGGAGCTGGCCACCATTTGTGCCCTCTGC
AATGACTCCTCCTTGGACTTCAATGAGACCAAAGGTATTTATGAGAAGGTGGGAGAGGCC
ACCGAGACAGCCCTCACCACCCTGGTGGAGAAGATGAATGTATTCAACACTGAAGTGAGA
AACCTCTCGAAGGTAGAGAGGGCCAACGCCTGCAACTCGGTGATCCGCCAGCTAATGAAG
AAGGAATTCACCCTGGAGTTCTCCCGGGACCGAAAGTCCATGTCTGTCTATTGCTCTCCA
GCAAAATCCCGGGCTGCTGTGGGCAATAAGATGTTTGTCAAGGGTGCCCCTGAGGGGGTC
ATCGATCGCTGTAACTACGTGCGAGTGGGCACCACCCGGGTGCCCATGACAGGGCCGGTG
AAGGAGAAGATTCTGTCGGTGATCAAAGAGTGGGGTACTGGCCGGGACACCCTGCGCTGC
CTGGCGCTGGCCACTCGGGACACCCCCCCCAAGCGAGAGGAGATGGTCCTGGATGACTCT
ACCAAGTTCATGGAGTACGAGACGGACTTGACATTCGTTGGCGTCGTGGGCATGCTGGAC
CCGCCCCGCAAGGAGGTCATGGGCTCCATCCAACTATGCCGAGACGCTGGAATCCGAGTA
ATCATGATCACCGGAGACAACAAGGGCACGGCCATTGCCATCTGCCGACGGATTGGCATC
TTCGGGGAGAACGAGGATGTGGCTGACCGGGCCTACACTGGCCGGGAGTTCGATGACCTG
CCCCTGGCCGAGCAGCGGGAGGCCTGCCGACGCGCCTGCTGCTTCGCCCGCGTGGAGCCC
ACCCACAAGTCGAAGATCGTGGAGTATCTGCAGTCCTTCGATGAGATCACGGCGATGACA
GGTGATGGCGTCAATGACGCCCCTGCGCTGAAGAAGGCGGAAATCGGCATTGCCATGGGA
TCCGGCACTGCCGTGGCCAAGACAGCCTCTGAGATGGTGCTGGCCGACGACAACTTCTCC
ACCATTGTGGCTGCCGTGGAGGAGGGCCGGGCCATCTACAACAACATGAAGCAGTTTATC
CGCTACCTCATCTCCTCCAACGTGGGCGAGGTGGTCTGCATCTTCCTGACAGCTGCCCTG
GGGCTGCCCGAGGCCCTGATCCCTGTGCAGCTGCTGTGGGTGAACCTGGTGACCGATGGG
CTCCCAGCCACAGCCCTGGGCTTCAACCCCCCAGACCTGGACATCATGGACCGGCCCCCC
CGGACCCCCAAGGAGCCCCTCATCAGTGGCTGGCTCTTCTTCCGCTACATGGCAATTGGG
GGCTATGTGGGTGCAGCCACCGTGGGAGCAGCGGCCTGGTGGTTCCTGTATGCTGAGGAC
GGGCCTCACGTCACCTACAGCCAGCTGACTCACTTCATGAAGTGCTCGGAGCACAGCCCA
GACTTCGAGGGTGTGGACTGTGAGGTCTTCGAGGCCCCGCAGCCCATGACCATGGCCTTG
TCTGTGCTGGTCACCATCGAGATGTGCAATGCTCTCAACAGCCTGTCTGAGAATCAGTCC
CTCGTGCGGATGCCACCCTGGGTGAACATCTGGCTGGTGGGCTCCATCGGCCTCTCCATG
TCCCTCCACTTCCTCATCCTCTACGTGGACCCTCTGCCGATGATCTTCAAGCTCCAAGCC
CTGGACCTGTACCATTGGCTCATGGTCCTCAAGATCTCATTACCAGTCATTGGGCTCGAC
GAAATCCTCAAGTTCGTTGCTCGAAACTACCTGGAGGGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 993 |
| Molecular Weight
| 109290.0 |
| Theoretical pI
| 4.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 49-69
- 90-110
- 254-273
- 296-313
- 757-776
- 787-807
- 828-850
- 897-916
- 930-948
- 964-984
|
| Protein Sequence
|
>Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
MEAAHSKTTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVLEQFEDL
LVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILTIKSTTLRVDQSIL
TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKAIGIVATTGVGTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDRIDGDLCLLNEFSVTGSTYAPEGEVLKNDKPVRSGQYDGLVELATICALC
NDSSLDFNETKGIYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPV
KEKILSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSTKFMEYETDLTFVGVVGMLD
PPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEDVADRAYTGREFDDL
PLAEQREACRRACCFARVEPTHKSKIVEYLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAL
GLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRTPKEPLISGWLFFRYMAIG
GYVGAATVGAAAWWFLYAEDGPHVTYSQLTHFMKCSEHSPDFEGVDCEVFEAPQPMTMAL
SVLVTIEMCNALNSLSENQSLVRMPPWVNIWLVGSIGLSMSLHFLILYVDPLPMIFKLQA
LDLYHWLMVLKISLPVIGLDEILKFVARNYLEG
|
| External Links |
|---|
| GenBank ID Protein
| AAI19939.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCY0 |
| UniProtKB/Swiss-Prot Entry Name
| AT2A1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC119938 |
| GeneCard ID
| ATP2A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
