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| Identification |
|---|
| BMDB Protein ID
| BMDBP00216 |
| Secondary Accession Numbers
| None |
| Name
| Pyridoxal phosphate phosphatase |
| Synonyms
|
Not Available
|
| Gene Name
| PDXP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (By similarity). |
| Pathways
|
|
| Reactions
|
| Pyridoxal 5'-phosphate + Water → Pyridoxal + Hydrogen phosphate |
details
|
| Pyridoxine 5'-phosphate + Water → Pyridoxine + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| PDXP |
| Gene Sequence
|
>891 bp
ATGGCGCGCTGCGAGCGGCTGCGCGGCGCGGCCCTGCGCGACGTGGTGGGCCGGGCGCAG
GGGGTCCTGTTCGACTGCAACGGGGTGCTGTGGAACGGCGAGCGCGCAGTGCCGGGCGCC
CCCGAGCTCCTGGAGAGACTGGCTCAGGCTGGCAAGGCGACGCTCTTCGTGAGCAACAAC
AGCCGGCGCGCGCGGCCCGAGCTGGCCCTCCGCTTCGCGCGACTTGGCTTCGGGGGGCTG
CGCTCCGAGCAGCTCTTCAGCTCCGCGCTGTGCGCCGCGCGCTTGCTGCGCCAGCGCCTG
CTCGGACCTCCGGACACTCAGGGCGCGGTGTTCGTGCTGGGCGGTGAAGGGCTGCGGGCC
GAGCTGCGCGCCGCCGGGCTGCGCCTGGCGGGGGACCCCAGCGAGGACCCGGGCGCGGCC
CCGCGCGTGCGCGCCGTGCTTGTGGGCTACGACGAGCACTTCTCCTTCGCCAAGCTGAGC
GAGGCCTGCGCGCACTTGCGCGACCCCGACTGCCTGCTGGTAGCCACCGACCGCGACCCG
TGGCACCCTCTCAGCGACGGCAGCCGGACCCCCGGCACCGGGAGCTTGGCTGCTGCTGTG
GAGACAGCCTCGGGCCGCCAGGCCCTGGTGGTGGGCAAGCCCAGCCCCTACATGTTCGAG
TGCATCACAGAGCACTTCAGCGTGGACCCCGGCCGCACGCTGATGGTGGGCGACCGCCTG
GAGACTGACATCCTCTTCGGCCACCGCTGTGGTATGACCACCGTGCTCACGCTCACGGGC
GTCTCCAGCCTGGAGGAGGCCCAGGCCTACCTGGCGGCCGGCCAGCACGACCTCGTGCCC
CATTACTACGTGGAGAGCATCGCGGACTTGATGGAGGGGTTGGAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 296 |
| Molecular Weight
| 31749.0 |
| Theoretical pI
| 5.91 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyridoxal phosphate phosphatase
MARCERLRGAALRDVVGRAQGVLFDCNGVLWNGERAVPGAPELLERLAQAGKATLFVSNN
SRRARPELALRFARLGFGGLRSEQLFSSALCAARLLRQRLLGPPDTQGAVFVLGGEGLRA
ELRAAGLRLAGDPSEDPGAAPRVRAVLVGYDEHFSFAKLSEACAHLRDPDCLLVATDRDP
WHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITEHFSVDPGRTLMVGDRL
ETDILFGHRCGMTTVLTLTGVSSLEEAQAYLAAGQHDLVPHYYVESIADLMEGLED
|
| External Links |
|---|
| GenBank ID Protein
| AAI03330.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBF9 |
| UniProtKB/Swiss-Prot Entry Name
| PLPP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103329 |
| GeneCard ID
| PDXP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
