Showing Protein Mitochondrial amidoxime reducing component 2 (BMDBP00221)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00221 |
| Secondary Accession Numbers | None |
| Name | Mitochondrial amidoxime reducing component 2 |
| Synonyms | Not Available |
| Gene Name | MTARC2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in molybdenum ion binding |
| Specific Function | Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 16 |
| Locus | Not Available |
| SNPs | MTARC2 |
| Gene Sequence |
>1011 bp ATGGGCGCCGCCGGCTCCTCGGCTCTGGCCCGCTTGGGCCTCCCCGCGCTGCCCGGGCCC CGCTGGCTGGGGGTGGCCGCCCTGGGACTGGCCGCAGTGGCGCTGGGGGCCGTCGCCTGG CGCCGCGCGCGGCCCGGTCGGCGCCGGCGGCTGCAGCAGGTGGGCACGGTGAGCGAGCTG TGGATCTACCCGATCAAATCCTGCAAAGGGGTGTCGGTGGACGCGGCCGAGTGCACGGCC CTGGGGCTGCGCAGCGGCCACCTGCGGGACAGGTTTTGGCTGGTGATAAAGGAAGATGGA CACATGGTGACTGGCCGGCAGGAACCTCAGCTTGTGCTGGTCTCCATCACCTATGAGGAC GATTGCCTGATCCTCAGGGCTCCAGGCATGGACCAGCTGGTTTTGCCGACCAAACTGCTT TCTTCAAACAAGCTCCATGACTGCAGGGTGTTTGGTCTTGACATCCAGGGCAGGGACTGT GGCGACGAGGCTGCTCAGTGGTTCACCAGCTTCTTGAAAACGGACGCGTTCAGGCTGGTT CAGTTTGAAAAGAACATGAAGGCAAGAGCGTCAAATGAAATTTTCCCTTCTTTGGACAAG AATTACCAGGTGGCCTACCCGGACTGCAGCCCCGTCATGATCCTGTCGGAAGCCTCCCTG GCCGATCTGAATACCAGGATGGAGAAGAAAGTGAAAATAAACAATTTCAGGCCAAATATC GTGGTGACAGGCTGCAGTGCTTTTGAGGAGGACACTTGGGATGAACTTCTCATTGGCAAT GTAGAAATGAAAAAGATTTTGGCTTGCCCCAGGTGCATTATGACCACGGTGGACCCAGAT ACTGGAGTGATTGACAGGAAGGAGCCACTCGAAACCCTGAAGAGTTACCGCCTGTGTGAT CCTTCTGAGAAGTCAATTTACAAGTCGTCCCCACTGTTTGGAATCTATTACTCGGTGGAA AAAATTGGAAGCCTGAAAGTTGGTGACCCCGTGTACCAGATGGTGCAGTGA |
| Protein Properties | |
| Number of Residues | 336 |
| Molecular Weight | 37288.0 |
| Theoretical pI | 8.24 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>MOSC domain-containing protein 2, mitochondrial MGAAGSSALARLGLPALPGPRWLGVAALGLAAVALGAVAWRRARPGRRRRLQQVGTVSEL WIYPIKSCKGVSVDAAECTALGLRSGHLRDRFWLVIKEDGHMVTGRQEPQLVLVSITYED DCLILRAPGMDQLVLPTKLLSSNKLHDCRVFGLDIQGRDCGDEAAQWFTSFLKTDAFRLV QFEKNMKARASNEIFPSLDKNYQVAYPDCSPVMILSEASLADLNTRMEKKVKINNFRPNI VVTGCSAFEEDTWDELLIGNVEMKKILACPRCIMTTVDPDTGVIDRKEPLETLKSYRLCD PSEKSIYKSSPLFGIYYSVEKIGSLKVGDPVYQMVQ |
| External Links | |
| GenBank ID Protein | AAI16002.1 |
| UniProtKB/Swiss-Prot ID | Q1LZH1 |
| UniProtKB/Swiss-Prot Entry Name | MARC2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC116001 |
| GeneCard ID | MTARC2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |