| Identification |
|---|
| BMDB Protein ID
| BMDBP00221 |
| Secondary Accession Numbers
| None |
| Name
| Mitochondrial amidoxime reducing component 2 |
| Synonyms
|
Not Available
|
| Gene Name
| MTARC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in molybdenum ion binding |
| Specific Function
| Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| MTARC2 |
| Gene Sequence
|
>1011 bp
ATGGGCGCCGCCGGCTCCTCGGCTCTGGCCCGCTTGGGCCTCCCCGCGCTGCCCGGGCCC
CGCTGGCTGGGGGTGGCCGCCCTGGGACTGGCCGCAGTGGCGCTGGGGGCCGTCGCCTGG
CGCCGCGCGCGGCCCGGTCGGCGCCGGCGGCTGCAGCAGGTGGGCACGGTGAGCGAGCTG
TGGATCTACCCGATCAAATCCTGCAAAGGGGTGTCGGTGGACGCGGCCGAGTGCACGGCC
CTGGGGCTGCGCAGCGGCCACCTGCGGGACAGGTTTTGGCTGGTGATAAAGGAAGATGGA
CACATGGTGACTGGCCGGCAGGAACCTCAGCTTGTGCTGGTCTCCATCACCTATGAGGAC
GATTGCCTGATCCTCAGGGCTCCAGGCATGGACCAGCTGGTTTTGCCGACCAAACTGCTT
TCTTCAAACAAGCTCCATGACTGCAGGGTGTTTGGTCTTGACATCCAGGGCAGGGACTGT
GGCGACGAGGCTGCTCAGTGGTTCACCAGCTTCTTGAAAACGGACGCGTTCAGGCTGGTT
CAGTTTGAAAAGAACATGAAGGCAAGAGCGTCAAATGAAATTTTCCCTTCTTTGGACAAG
AATTACCAGGTGGCCTACCCGGACTGCAGCCCCGTCATGATCCTGTCGGAAGCCTCCCTG
GCCGATCTGAATACCAGGATGGAGAAGAAAGTGAAAATAAACAATTTCAGGCCAAATATC
GTGGTGACAGGCTGCAGTGCTTTTGAGGAGGACACTTGGGATGAACTTCTCATTGGCAAT
GTAGAAATGAAAAAGATTTTGGCTTGCCCCAGGTGCATTATGACCACGGTGGACCCAGAT
ACTGGAGTGATTGACAGGAAGGAGCCACTCGAAACCCTGAAGAGTTACCGCCTGTGTGAT
CCTTCTGAGAAGTCAATTTACAAGTCGTCCCCACTGTTTGGAATCTATTACTCGGTGGAA
AAAATTGGAAGCCTGAAAGTTGGTGACCCCGTGTACCAGATGGTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 37288.0 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>MOSC domain-containing protein 2, mitochondrial
MGAAGSSALARLGLPALPGPRWLGVAALGLAAVALGAVAWRRARPGRRRRLQQVGTVSEL
WIYPIKSCKGVSVDAAECTALGLRSGHLRDRFWLVIKEDGHMVTGRQEPQLVLVSITYED
DCLILRAPGMDQLVLPTKLLSSNKLHDCRVFGLDIQGRDCGDEAAQWFTSFLKTDAFRLV
QFEKNMKARASNEIFPSLDKNYQVAYPDCSPVMILSEASLADLNTRMEKKVKINNFRPNI
VVTGCSAFEEDTWDELLIGNVEMKKILACPRCIMTTVDPDTGVIDRKEPLETLKSYRLCD
PSEKSIYKSSPLFGIYYSVEKIGSLKVGDPVYQMVQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI16002.1 |
| UniProtKB/Swiss-Prot ID
| Q1LZH1 |
| UniProtKB/Swiss-Prot Entry Name
| MARC2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC116001 |
| GeneCard ID
| MTARC2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
