Showing Protein Angiogenin-1 (BMDBP00230)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00230 |
| Secondary Accession Numbers | None |
| Name | Angiogenin-1 |
| Synonyms | Not Available |
| Gene Name | ANG1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in actin binding |
| Specific Function | Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | ANG1 |
| Gene Sequence |
>447 bp ATGGTCATGGTCCTGAGCCCCCTGCTTTTGGTCTTCATACTGGGTCTGGGTCTGACCCCA GTGGCCCCGGCTCAAGATGACTACAGATACATACACTTCCTGACCCAGCACTACGATGCC AAACCAAAGGGCCGGAATGACGAATATTGTTTTAACATGATGAAAAATCGACGCCTGACC AGACCTTGCAAAGACCGCAACACCTTTATTCATGGCAACAAGAATGACATTAAGGCCATC TGTGAGGACAGAAATGGACAGCCTTACAGAGGCGATCTCAGAATAAGCAAGTCTGAATTC CAGATCACCATCTGCAAGCATAAAGGAGGTTCCTCCCGGCCTCCATGCCGTTACGGAGCC ACAGAAGACTCCAGAGTCATTGTTGTGGGCTGTGAAAATGGCTTGCCGGTCCACTTTGAT GAGTCCTTTATCACTCCACGCCACTAG |
| Protein Properties | |
| Number of Residues | 148 |
| Molecular Weight | 16970.0 |
| Theoretical pI | 9.04 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Angiogenin-1 MVMVLSPLLLVFILGLGLTPVAPAQDDYRYIHFLTQHYDAKPKGRNDEYCFNMMKNRRLT RPCKDRNTFIHGNKNDIKAICEDRNGQPYRGDLRISKSEFQITICKHKGGSSRPPCRYGA TEDSRVIVVGCENGLPVHFDESFITPRH |
| External Links | |
| GenBank ID Protein | AAG47631.1 |
| UniProtKB/Swiss-Prot ID | P10152 |
| UniProtKB/Swiss-Prot Entry Name | ANG1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AF135124 |
| GeneCard ID | ANG1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |