| Identification |
|---|
| BMDB Protein ID
| BMDBP00231 |
| Secondary Accession Numbers
| None |
| Name
| Platelet-activating factor acetylhydrolase IB subunit alpha |
| Synonyms
|
Not Available
|
| Gene Name
| PAFAH1B1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in dynactin binding |
| Specific Function
| Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing (By similarity). Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Required for pronuclear migration during fertilization. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| PAFAH1B1 |
| Gene Sequence
|
>1233 bp
ATGGTGCTGTCCCAGAGACAACGAGATGAACTAAATCGAGCTATAGCAGATTATCTTCGT
TCAAATGGCTACGAAGCCGCATATTCAGTTTTTAAAAAGGAAGCTGAATTAGATATGAAT
GAAGAATTAGATAAGAAATATGCTGGTCTTTTGGAAAAAAAATGGACATCTGTTATTAGA
TTACAAAAGAAGGTTATGGAATTAGAATCAAAGTTAAATGAAGCAAAAGAAGAATTTACG
TCGGGTGGACCTCTTGGTCAGAAAAGAGACCCAAAAGAATGGATTCCCCGTCCACCAGAA
AAATATGCATTGAGTGGTCATAGGAGTCCAGTCACTCGAGTCATTTTCCATCCTGTGTTC
AGTGTTATGGTCTCTGCTTCAGAGGATGCTACAATTAAGGTGTGGGATTATGAGACTGGA
GATTTTGAACGAACTCTTAAGGGGCATACAGACTCTGTAGAGGATATTTCATTCGACCAC
AGTGGCAAGCTTCTGGCTTCATGTTCTGCAGATATGACCATTAAGCTATGGGATTTTCAG
GGCTTTGAATGCATCAGAACCATGCATGGCCATGACCACAATGTTTCTTCAGTAGCCATC
ATGCCCAATGGAGATCATATAGTGTCTGCCTCAAGGGATAAAACTATAAAAATGTGGGAA
GTGCAAACTGGCTACTGTGTGAAGACATTCACAGGACACAGAGAATGGGTACGTATGGTG
CGGCCAAATCAAGACGGCACTCTGATAGCCAGCTGTTCCAATGACCAGACTGTGCGTGTA
TGGGTCGTAGCAACAAAGGAATGCAAGGCTGAGCTTCGAGAACATGAGCATGTGGTAGAA
TGCATTTCCTGGGCTCCTGAAAGCTCATATTCTTCCATCTCTGAAGCAACAGGATCTGAG
ACTAAAAAAAGTGGCAAACCTGGGCCATTCTTACTGTCCGGATCCAGGGACAAGACTATC
AAGATGTGGGATGTCAGTACTGGCATGTGCCTTATGACCCTGGTGGGTCATGATAACTGG
GTACGTGGAGTTCTGTTCCATTCTGGGGGGAAGTTTATTTTGAGTTGCGCTGATGACAAG
ACCCTGCGCGTGTGGGATTACAAGAACAAGCGATGCATGAAGACCCTCAATGCGCATGAA
CACTTTGTTACCTCCTTGGATTTCCATAAGACGGCCCCATATGTGGTTACTGGCAGTGTA
GATCAAACAGTAAAGGTGTGGGAGTGTCGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 410 |
| Molecular Weight
| 46613.0 |
| Theoretical pI
| 7.4 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Platelet-activating factor acetylhydrolase IB subunit alpha
MVLSQRQRDELNRAIADYLRSNGYEAAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVEDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
|
| External Links |
|---|
| GenBank ID Protein
| BAA06305.1 |
| UniProtKB/Swiss-Prot ID
| P43033 |
| UniProtKB/Swiss-Prot Entry Name
| LIS1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| D30615 |
| GeneCard ID
| PAFAH1B1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
