Showing Protein Disintegrin and metalloproteinase domain-containing protein 10 (BMDBP00233)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00233 |
| Secondary Accession Numbers | None |
| Name | Disintegrin and metalloproteinase domain-containing protein 10 |
| Synonyms | Not Available |
| Gene Name | ADAM10 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in metalloendopeptidase activity |
| Specific Function | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:10097139). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | ADAM10 |
| Gene Sequence |
>2247 bp ATGGTGTTGCTGAGAGTGTTAATTCTGCTCCTCTCCTGGGTTGCGGGGCTGGGAGGTCAG TATGGAAATCCTTTAAATAAATACATTAGACATTATGAAGGATTATCATATGATGTGGAT TCATTACACCAAAAACACCAGCGTGCCAAAAGAGCAGTATCACATGAGGACCAGTTTTTA CGGCTAGATTTTCATGCTCATGGAAGACATTTCAACCTTCGAATGAAGAGGGATACTTCC CTTTTCAGTGAGGAGTTTAGGGTGGAAACATCAAATGCAGTACTGGATTATGATACTTCT CATATTTACACTGGACATATTTATGGTGAAGAAGGAAGTTTTAGCCATGGGTCTGTTATT GATGGAAGATTTGAAGGATTCATTCAGACTCATGGTGGCACATTTTATGTTGAACCAGCA GAGAGATATATTAAAGACCGAACTCTGCCATTTCACTCTGTCATTTATCATGAAGATGAT ATTAAGTATCCCCATAAATATGGTCCACAGGGGGGTTGTGCAGATCATTCAGTGTTTGAA AGAATGAGGAAGTACCAGATGACTGGTGTAGAAGAAGTAACACAGACACCTCAAGAAAAA CATGCTATTAATGGTCCAGAACTCCTGAGGAAAAAACGTACAACTGTAGCTGAAAAAAAT ACCTGTCAGCTTTATATTCAGACCGATCATCTGTTCTTTAAATATTACGGAACACGAGAA GCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCAATTGACACAATTTACCAGACAACA GACTTCTCTGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAATCAACACAACT GCTGATGAGAAGGACCCTACAAATCCATTCCGTTTTCCAAATATTGGTGTGGAGAAGTTT CTGGAGCTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTACGTTTTCACAGAT CGAGATTTTGATGATGGTGTCCTTGGTCTGGCGTGGGTTGGAGCACCTTCAGGAAGCTCT GGAGGAATATGTGAAAAAAGTAAGCTCTATTCAGATGGTAAGAAGAAGTCTTTAAACACT GGAATTATTACTGTTCAGAACTATGGGTCTCACGTACCCCCCAAAGTCTCTCACATTACG TTTGCTCATGAAGTTGGACATAACTTTGGATCTCCGCATGATTCTGGAACAGAGTGCACT CCAGGAGAATCTAAGAATTTAGGACAAAAAGAAAATGGCAACTACATCATGTATGCAAGA GCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATA AGTCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCAACCTATTTGT GGAAATGGGATGGTAGAACAAGGTGAAGAATGTGATTGTGGTTATAGTGACCAGTGTAAA GACGAGTGCTGCTACGATGCAAATCAGCCGGAGGGGAAAAAATGCAAGCTGAAACCTGGA AAGCAGTGCAGTCCAAGTCAAGGTCCCTGTTGTACAGCACATTGTGCATTCAAGTCAAAA ACTGAAAAGTGTCGGGATGATTCAGACTGTGCAAAAGAAGGAATATGTAATGGCATCACA GCTCTCTGCCCAGCCTCTGATCCTAAACCGAACTTCACAGACTGTAATAGACATACGCAA GTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAACATGGCTTGGAGGAGTGT ACCTGTGCCAGTTCTGATGGCAAAGATGATAAGGAATTATGCCATGTCTGCTGTATGAAG AAGATGGAGCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAACAAGTACTTCCTT GGTCGAACTATCACCCTGCAACCTGGATCCCCATGCAATGATTTTAGAGGCTACTGTGAT GTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCGAGGCTTAAAAAAGCA ATTTTCAGTCCAGAGCTCTATGAAAACATAGCTGAATGGATTGTGGCTTACTGGTGGGCA GTATTACTTATGGGAATTGCCCTGATCATGTTAATGGCTGGTTTTATTAAGATATGCAGT GTACACACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCTCTTCCAGGCACTTTA AAGAGGAGAAGACCTCCCCAGCCCATTCAACAGCCCCAGCGTCAGAGGCCCCGGGAGAGT TATCAGATGGGACACATGAGACGTTAA |
| Protein Properties | |
| Number of Residues | 748 |
| Molecular Weight | 84188.0 |
| Theoretical pI | 7.81 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Disintegrin and metalloproteinase domain-containing protein 10 MVLLRVLILLLSWVAGLGGQYGNPLNKYIRHYEGLSYDVDSLHQKHQRAKRAVSHEDQFL RLDFHAHGRHFNLRMKRDTSLFSEEFRVETSNAVLDYDTSHIYTGHIYGEEGSFSHGSVI DGRFEGFIQTHGGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFE RMRKYQMTGVEEVTQTPQEKHAINGPELLRKKRTTVAEKNTCQLYIQTDHLFFKYYGTRE AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK DECCYDANQPEGKKCKLKPGKQCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGIT ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTCASSDGKDDKELCHVCCMK KMEPSTCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA IFSPELYENIAEWIVAYWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL KRRRPPQPIQQPQRQRPRESYQMGHMRR |
| External Links | |
| GenBank ID Protein | CAA79973.1 |
| UniProtKB/Swiss-Prot ID | Q10741 |
| UniProtKB/Swiss-Prot Entry Name | ADA10_BOVIN |
| PDB IDs | |
| GenBank Gene ID | Z21961 |
| GeneCard ID | ADAM10 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |