| Identification |
|---|
| BMDB Protein ID
| BMDBP00236 |
| Secondary Accession Numbers
| |
| Name
| Lipoprotein lipase |
| Synonyms
|
Not Available
|
| Gene Name
| LPL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in apolipoprotein binding |
| Specific Function
| Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:9188470). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| LPL |
| Gene Sequence
|
>1437 bp
ATGGAGAGCAAGGCCCTACTTCTGCTGGCTCTGAGCGTGTGCCTGCAGAGTCTGACCGTC
TCCCGCGGAGGGCTGGTCGCCGCAGACAGGATTACAGGAGGAAAAGATTTTAGAGACATT
GAAAGTAAATTTGCTCTCAGGACTCCCGAAGACACAGCTGAGGACACTTGCCACCTCATT
CCTGGAGTGACCGAATCTGTGGCTAACTGTCACTTCAACCACAGCAGCAAAACCTTTGTG
GTGATCCATGGCTGGACGGTGACAGGAATGTATGAGAGTTGGGTGCCAAAACTCGTGGCT
GCCTTGTACAAGAGGGAACCGGACTCCAACGTCATCGTGGTGGACTGGCTGTCACGGGCC
CAGCAGCATTATCCAGTGTCTGCAGGGTACACCAAGCTGGTGGGACAGGATGTGGCCAAG
TTTATGAACTGGATGGCGGATGAATTTAACTATCCCCTGGGCAATGTGCATCTCTTGGGA
TACAGCCTTGGGGCCCATGCTGCTGGTATTGCAGGAAGTCTGACCAATAAGAAGGTCAAC
AGGATAACCGGCTTAGATCCAGCTGGACCTAACTTCGAGTATGCAGAAGCTCCAAGTCGC
CTTTCTCCTGATGATGCGGATTTTGTAGACGTTTTACACACATTCACCAGGGGGTCACCA
GGTCGAAGTATCGGAATCCAGAAACCAGTAGGGCATGTGGACATTTACCCTAACGGAGGC
ACTTTCCAACCAGGATGTAACATTGGGGAAGCTCTCCGTGTGATTGCAGAGAGAGGCCTT
GGAGATGTGGATCAGCTGGTGAAGTGCTCCCACGAACGTTCCGTTCATCTCTTCATTGAC
TCTCTGTTGAATGAAGAAAATCCAAGTAAGGCCTACCGGTGCAATTCCAAAGAAGCCTTT
GAGAAAGGTCTCTGCCTGAGCTGCAGAAAGAACCGTTGCAACAACATGGGCTACGAGATC
AACAAGGTCAGAGCCAAAAGAAGCAGCAAGATGTACCTGAAGACTCGTTCTCAGATGCCT
TACAAAGTCTTCCATTACCAAGTAAAGATACATTTTTCTGGAACTGAGAGTAATACATAC
ACCAACCAGGCCTTCGAGATCTCTCTGTATGGCACTGTGGCTGAGAGCGAGAACATCCCT
TTTACCCTGCCTGAAGTTTCCACAAATAAGACATACTCCTTTCTACTTTACACGGAGGTG
GATATTGGAGAATTGCTAATGTTGAAACTCAAATGGATTAGTGATTCCTACTTCAGCTGG
TCCAACTGGTGGAGCAGCCCCGGCTTTGATATTGGGAAGATCAGAGTAAAGGCAGGAGAG
ACTCAAAAAAAGGTGATCTTCTGTTCCCGGGAGAAAATGTCTTATCTGCAGAAAGGAAAG
TCACCTGTGATATTTGTGAAATGCCATGACAAGTCCCTGAATAGAAAGTCTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 478 |
| Molecular Weight
| 53378.0 |
| Theoretical pI
| 8.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lipoprotein lipase
MESKALLLLALSVCLQSLTVSRGGLVAADRITGGKDFRDIESKFALRTPEDTAEDTCHLI
PGVTESVANCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRA
QQHYPVSAGYTKLVGQDVAKFMNWMADEFNYPLGNVHLLGYSLGAHAAGIAGSLTNKKVN
RITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGG
TFQPGCNIGEALRVIAERGLGDVDQLVKCSHERSVHLFIDSLLNEENPSKAYRCNSKEAF
EKGLCLSCRKNRCNNMGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESNTY
TNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLLYTEVDIGELLMLKLKWISDSYFSW
SNWWSSPGFDIGKIRVKAGETQKKVIFCSREKMSYLQKGKSPVIFVKCHDKSLNRKSG
|
| External Links |
|---|
| GenBank ID Protein
| AAI18092.1 |
| UniProtKB/Swiss-Prot ID
| P11151 |
| UniProtKB/Swiss-Prot Entry Name
| LIPL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118091 |
| GeneCard ID
| LPL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
