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| Identification |
|---|
| BMDB Protein ID
| BMDBP00237 |
| Secondary Accession Numbers
| |
| Name
| Argininosuccinate synthase |
| Synonyms
|
Not Available
|
| Gene Name
| ASS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. |
| Pathways
|
- (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1
- Amino-acid biosynthesis
- L-arginine biosynthesis
- L-arginine from L-ornithine and carbamoyl phosphate: step 2/3
- Nitrogen metabolism
- Urea Cycle
|
| Reactions
|
| Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Pyrophosphate + Argininosuccinic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| ASS1 |
| Gene Sequence
|
>1239 bp
ATGTCCGGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGGGGCCTGGACACCTCCTGCATC
CTCGTGTGGCTGAAGGAGCAAGGCTATGACGTCATTGCCTACCTGGCCAACATCGGCCAG
AAAGAAGACTTTGAGGAAGCCAGGAAGAAGGCGCTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGACATCAGCAAGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTACGAGGACCGATACCTCCTGGGCACCTCTCTCGCCAGGCCCTGCATCGCCCGC
AAGCAGGTGGAGATCGCCCAGCGAGAAGGAGCCAAGTATGTGTCTCACGGCGCCACAGGA
AAGGGGAACGACCAGATCCGGTTTGAGCTCACCTGCTACTCGCTGGCCCCACAGATCAAG
GTCATCGCTCCCTGGAGGATGCCCGAGTTCTATAACCGCTTCCAGGGCCGCAACGATCTG
ATGGAGTATGCGAAGCAACATGGAATCCCCGTCCCAGTCACCCCCAAGAACCCGTGGAGC
ATGGACGAGAACCTGATGCATATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGCCTCTACACAAAGACCCAGGACCCGGCCAAAGCCCCCAACAGCCCG
GACATGCTCGAGATCGAGTTCAAGAAAGGGGTCCCCGTGAAGGTGACCAACGTCGGGGAT
GGCACCACCCACAGCACAGCGTTGGAGCTTTTCCTGTACCTGAATGAAGTCGCTGGCAAG
CACGGCGTGGGCCGCATCGACATCGTGGAAAACCGCTTCATCGGGATGAAGTCCCGGGGT
ATCTACGAGACCCCAGCGGGGACGATCCTTTACCACGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAGCAAGGCCTCGGCTTGAAATTCGCCGAGCTG
GTCTACACGGGTTTCTGGCACAGCCCCGAGTGTGAATTTGTCCGCCACTGCATTGCCAAG
TCCCAGGAGCGCGTGGAAGGGAAAGTGCAGGTGTCCGTCTTCAAGGGCCAGGTGTACATC
CTTGGCCGGGAGTCCCCACTGTCCCTCTACAATGAGGAGCTCGTGAGCATGAACGTGCAG
GGAGACTACGAGCCGGTTGATGCCACTGGTTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGCCTCCAGAACAAGGTCACCGCCAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 46417.0 |
| Theoretical pI
| 7.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Argininosuccinate synthase
MSGKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDISKEFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQIRFELTCYSLAPQIKVIAPWRMPEFYNRFQGRNDLMEYAKQHGIPVPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNSPDMLEIEFKKGVPVKVTNVGD
GTTHSTALELFLYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVFKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPVDATGFININSLRLKEYHRLQNKVTAK
|
| External Links |
|---|
| GenBank ID Protein
| AAA30388.1 |
| UniProtKB/Swiss-Prot ID
| P14568 |
| UniProtKB/Swiss-Prot Entry Name
| ASSY_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M26198 |
| GeneCard ID
| ASS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
