| Identification |
|---|
| BMDB Protein ID
| BMDBP00239 |
| Secondary Accession Numbers
| |
| Name
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| AADAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). |
| Pathways
|
- Amino-acid degradation
- Glutaryl-CoA from L-lysine: step 4/6
- L-lysine degradation via saccharopine pathway
|
| Reactions
|
| Aminoadipic acid + Oxoglutaric acid → Oxoadipic acid + L-Glutamic acid |
details
|
| L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid |
details
|
| L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| AADAT |
| Gene Sequence
|
>1278 bp
ATGAATTACGCTCGGTTCATTACCGCCACGAGCGCGGCCAGAAAGCCTTCTACCATCCGA
GTCATGACTGAAATATTGAGCAAGGCACCGAAATCTGTCATCTCCTTGGCAACTGGGGCA
CCAAACCCCAACACGTTCCCTTTCAAGACTGCGGTCATCACCATAGAAAACGGAAAACCC
ATCCAATTTAATGAACAGATGATGAAGAGAGCACTGCAGTATTCTCAGAGTGCTGGAATC
CCAGAGCTGTTATCCTGGCTAAAACAGTTACAAGTAAAATTGCATAATCCGCCCACCATC
CATTATGCACCCACCCAAGGACAGATGGACTTATGTGTCACATGTGGCAGCCAAGAAGGT
CTCTGTAAGGTATTTGAAATGATCGTTAATCCTGGAGATAATATCCTTGTAAATGAACCT
ATTTATTCAGGAACAATTCATGCTCTGCAACCCCTGGGCTGCAACATGATTAATGTTTCC
AGTGATGAGCACGGGATTATTCCAGACTCCCTCAGAGAAATACTTTCCAAATGGAAACCA
GAAGATTCAAAGAACCCCAAGAAAAACAGCCCCAAATTTCTTTACACTGTCCCAAATGGC
AACAACCCCTCTGGGAACTCATTAACAGCTGAGCGCAAAAGGGAAATCTATGAGCTCGCA
AGAAAATATGACTTCCTCATCATAGAAGATGATCCTTACTATTTTATGCAGTTCAACAAG
CCCTGGGCACCGACATTTCTCTCCATGGACGAGGATGGGCGCGTCATCCGAGCTGACTCT
TTTTCCAAAGTCCTGTCCTCAGGGTTGAGAATAGGGTTTATAACTGGTCCAAAGCCCTTG
ATTGAGAGAATTGTTTTACACATACAAGTTTCAACAATGCACCCCAGCACTTTTGCTCAG
CTCCTGGTATCACAGCTTCTATACCAATGGGGAGAAGAGGGCTTCCTGGGTCACGTAGAC
AGGGTTATTGATTTCTACAGGAAGCAGAGGGATGCATTAATGGCAGCAGCAGACAAGTGG
TTAAGTGGTTTGGCAGAATGGCATGTTCCTACTGCAGGAATGTTTCTATGGGTTAAAATT
AAGGGCATTCATGATGTAAGAAAACTGATCGAAGAAAAAGCCTTTAAGAAAGAGATATTC
ATGCTTCCGGGATGTGGTTTCTACACTGACAGTTCAGCTCCTTGCCCGTACTTCAGAGCA
TCCTTCTCTTCAGCTTCTCCAGAACAGATGGACTTGGCCTTTCAGAGACTGGCCCAACTT
ATAAAAGAATCTTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 425 |
| Molecular Weight
| 47901.0 |
| Theoretical pI
| 8.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
MNYARFITATSAARKPSTIRVMTEILSKAPKSVISLATGAPNPNTFPFKTAVITIENGKP
IQFNEQMMKRALQYSQSAGIPELLSWLKQLQVKLHNPPTIHYAPTQGQMDLCVTCGSQEG
LCKVFEMIVNPGDNILVNEPIYSGTIHALQPLGCNMINVSSDEHGIIPDSLREILSKWKP
EDSKNPKKNSPKFLYTVPNGNNPSGNSLTAERKREIYELARKYDFLIIEDDPYYFMQFNK
PWAPTFLSMDEDGRVIRADSFSKVLSSGLRIGFITGPKPLIERIVLHIQVSTMHPSTFAQ
LLVSQLLYQWGEEGFLGHVDRVIDFYRKQRDALMAAADKWLSGLAEWHVPTAGMFLWVKI
KGIHDVRKLIEEKAFKKEIFMLPGCGFYTDSSAPCPYFRASFSSASPEQMDLAFQRLAQL
IKESL
|
| External Links |
|---|
| GenBank ID Protein
| AAX08861.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9N4 |
| UniProtKB/Swiss-Prot Entry Name
| AADAT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020844 |
| GeneCard ID
| AADAT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
