| Identification |
|---|
| BMDB Protein ID
| BMDBP00240 |
| Secondary Accession Numbers
| None |
| Name
| 14-3-3 protein zeta/delta |
| Synonyms
|
Not Available
|
| Gene Name
| YWHAZ |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein domain specific binding |
| Specific Function
| Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| YWHAZ |
| Gene Sequence
|
>738 bp
ATGGATAAAAACGAGCTGGTACAGAAGGCCAAACTGGCCGAGCAGGCTGAGCGATATGAT
GACATGGCAGCCTGCATGAAGTCTGTAACTGAGCAAGGAGCTGAATTATCCAATGAGGAG
AGGAATCTTCTCTCAGTTGCTTATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGG
GTCGTCTCCAGTATTGAGCAAAAGACGGAAGGTGCTGAGAAAAAACAGCAGATGGCTCGA
GAATACAGAGAGAAAATAGAGACCGAGCTAAGAGATATCTGCAATGATGTACTGTCTCTT
TTGGAAAAGTTCTTGATCCCCAACGCTTCACAAGCAGAGAGCAAAGTCTTCTATTTGAAA
ATGAAAGGAGACTACTACCGCTACTTGGCTGAGGTTGCAGCTGGTGATGACAAGAAAGGG
ATTGTGGACCAGTCACAGCAAGCATACCAAGAAGCTTTTGAAATCAGCAAAAAGGAAATG
CAACCAACACATCCTATCAGACTGGGTCTGGCCCTTAACTTCTCTGTGTTCTATTATGAG
ATTCTGAACTCCCCTGAGAAAGCCTGCTCTCTTGCAAAGACAGCATTTGATGAAGCCATT
GCTGAACTTGATACATTAAGTGAAGAGTCATACAAAGACAGCACGCTAATAATGCAGTTA
CTGAGAGATAACTTGACATTGTGGACATCGGATACCCAAGGAGACGAAGCTGAAGCAGGA
GAAGGAGGGGAAAATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 245 |
| Molecular Weight
| 27745.0 |
| Theoretical pI
| 4.43 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>14-3-3 protein zeta/delta
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWR
VVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLK
MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYE
ILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAG
EGGEN
|
| External Links |
|---|
| GenBank ID Protein
| AAA30514.1 |
| UniProtKB/Swiss-Prot ID
| P63103 |
| UniProtKB/Swiss-Prot Entry Name
| 1433Z_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| L07955 |
| GeneCard ID
| YWHAZ |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
