| Identification |
|---|
| BMDB Protein ID
| BMDBP00243 |
| Secondary Accession Numbers
| None |
| Name
| 14-3-3 protein beta/alpha |
| Synonyms
|
Not Available
|
| Gene Name
| YWHAB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein domain specific binding |
| Specific Function
| Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| YWHAB |
| Gene Sequence
|
>741 bp
ATGACCATGGATAAAAGTGAGCTGGTACAGAAAGCCAAGCTCGCCGAGCAGGCCGAGCGC
TACGATGACATGGCTGCGGCCATGAAGGCGGTCACAGAGCAGGGGCACGAGCTCTCCAAC
GAGGAGAGAAACCTGCTGTCCGTCGCCTACAAGAATGTGGTCGGCGCCCGCCGTTCGTCC
TGGCGTGTCATCTCCAGCATCGAACAGAAAACTGAGAGGAACGAGAAGAAGCAGCAGATG
GGCAAAGAGTACCGCGAGAAGATCGAGGCCGAGCTGCAGGACATCTGCAATGACGTGCTG
GAGCTGTTGGATAAATACCTTATTCCCAATGCTACACAACCAGAAAGTAAGGTGTTCTAC
TTGAAAATGAAAGGCGATTATTTTAGATATCTTTCTGAGGTGGCTTCTGGAGACAATAAA
CAAACCACTGTGTCGAACTCCCAGCAGGCTTACCAAGAAGCATTTGAAATTAGTAAGAAA
GAAATGCAGCCTACACACCCCATTCGACTGGGGCTGGCACTTAATTTCTCCGTCTTTTAT
TATGAGATTCTAAACTCTCCTGAAAAGGCTTGCAGCCTGGCAAAAACGGCGTTTGATGAG
GCGATTGCTGAATTGGACACACTGAATGAAGAGTCTTACAAAGACAGCACCCTGATTATG
CAGCTGCTTAGGGACAATCTCACTCTGTGGACGTCGGAAAACCAGGGAGACGAAGGAGAT
GCTGGGGAGGGAGAGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 246 |
| Molecular Weight
| 28081.0 |
| Theoretical pI
| 4.51 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>14-3-3 protein beta/alpha
MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS
WRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLQLLDKYLIPNATQPESKVFY
LKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFY
YEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGD
AGEGEN
|
| External Links |
|---|
| GenBank ID Protein
| AAI20113.1 |
| UniProtKB/Swiss-Prot ID
| P68250 |
| UniProtKB/Swiss-Prot Entry Name
| 1433B_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120112 |
| GeneCard ID
| YWHAB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
