| Identification |
|---|
| BMDB Protein ID
| BMDBP00247 |
| Secondary Accession Numbers
| None |
| Name
| Palmitoyltransferase ZDHHC6 |
| Synonyms
|
Not Available
|
| Gene Name
| ZDHHC6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyltransferase activity |
| Specific Function
| Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| ZDHHC6 |
| Gene Sequence
|
>1242 bp
ATGGGTACATTCTGCTCAGTTGTCAAGTTTGAAAATCTCCAAGAATTAAAGAGACTTTGT
CACTGGGGTCCCATTATAGCCCTTGGTGTTATAGCAATATGTTCTGCCATGGCCATGATT
GACTCTGTGTTGTGGTATTGGCCCTTACATACCACTGGAGGAAGCGTGAATTTCATCATG
TTGATTAACTGGACTGTCATGATTCTTTATAATTACTTCAATGCCATGTTTGTTGGTCCT
GGCTTCGTCCCTCTGGGGTGGAAACCGGAAAATTCTCAGGATAGCGTGTACCTCCAGTAC
TGTAAAGTCTGCCAAGCATACAAGGCACCACGGTCACATCACTGCAGAAAGTGTAACAGA
TGTGTGATGAAGATGGACCATCACTGCCCTTGGATCAACAACTGCTGCGGCTATCAGAAT
CATGCTTCCTTCACGCTGTTCCTCCTTTTAGCACCACTGGGCTGTATTCACGCTGCCTTT
ATTTTTGTTATGACCATGTATACGCAGCTTTATAATCGGCTCTCCTTTGGGTGGAACACG
GTCAAGATTGATATGAGTGCAGCCCGGAGAGACCCTCTTCCGATTATTCCTTTTGGATTA
GCTGCATTTGCTGCCACCTTGTTTGCCTTGGGATTAGCTTTAGGAACAACCATAGCTGTC
GGGATGTTGTTTTTTATCCAGATGAAAATAATTCTCAGAAACAAAACTTCTATTGAATCA
TGGATTGAAGAGAAGGCTAAAGATCGAATTCAGTATTATCAACTAGATGAAGTCTTTGTT
TTTCCTTATGATATGGGAAGTAGATGGAAGAACTTCAAACAAGTATTCACATGGTCAGGG
GTCCCTGAAGGAGATGGACTGGATTGGCCAATCAGAGAAGGCTGTCACCAGTACAGCTTA
ACAATAGAACAGTTGAAACAAAAAGCAGATAAAAGAGTCAGAAGTGTCCGGTATAAAGTG
ATAGAAGATTATAGTGGTACCTGCTGTCCTTTGAATAGAGGAATCAAAACATTCTTCACG
AGCCCCTGCACTGAAGAGCCTCGGATAAGGCTACAGAAAGGGGAATTCATCTTAGCTACA
AGAGGGTTACGATACTGGTTGTATGGAGACAAAATTCTTGATGATTCCGTTTTAGAAGGT
GTTTCAAGAATAAGAGGATGGTTCCCTAGAAACTGTGTAGAAAAGTGCCCCTGTGACGCC
GAAACAGATCAAGCCCCAGAGGGCGAGAAGAAAAATAGATAG
|
| Protein Properties |
|---|
| Number of Residues
| 413 |
| Molecular Weight
| 47531.0 |
| Theoretical pI
| 8.55 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 25-45
- 58-78
- 144-164
- 206-226
|
| Protein Sequence
|
>Probable palmitoyltransferase ZDHHC6
MGTFCSVVKFENLQELKRLCHWGPIIALGVIAICSAMAMIDSVLWYWPLHTTGGSVNFIM
LINWTVMILYNYFNAMFVGPGFVPLGWKPENSQDSVYLQYCKVCQAYKAPRSHHCRKCNR
CVMKMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYNRLSFGWNT
VKIDMSAARRDPLPIIPFGLAAFAATLFALGLALGTTIAVGMLFFIQMKIILRNKTSIES
WIEEKAKDRIQYYQLDEVFVFPYDMGSRWKNFKQVFTWSGVPEGDGLDWPIREGCHQYSL
TIEQLKQKADKRVRSVRYKVIEDYSGTCCPLNRGIKTFFTSPCTEEPRIRLQKGEFILAT
RGLRYWLYGDKILDDSVLEGVSRIRGWFPRNCVEKCPCDAETDQAPEGEKKNR
|
| External Links |
|---|
| GenBank ID Protein
| AAI13244.1 |
| UniProtKB/Swiss-Prot ID
| Q2HJ95 |
| UniProtKB/Swiss-Prot Entry Name
| ZDHC6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC113243 |
| GeneCard ID
| ZDHHC6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
