| Identification |
|---|
| BMDB Protein ID
| BMDBP00249 |
| Secondary Accession Numbers
| None |
| Name
| Probable palmitoyltransferase ZDHHC21 |
| Synonyms
|
Not Available
|
| Gene Name
| ZDHHC21 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ZDHHC21 |
| Gene Sequence
|
>798 bp
ATGGGTCTCCGGATTCACTTTGTTGTTGACCCACATGGTTGGTGCTGCATGGGTTTGATT
GTCTTTGTCTGGTTATACAACTTTTTTTTAATTCCTAAGATTGTCCTCTTTCCTCACTAT
GAAGAAGGACATATTCCAGGCATATTAATAATAATATTCTATGGCATTGCCATGTTTTGT
CTGGTTGCTTTAGTGAGGGCCTCAATAACTGATCCAGGAAGACTCCCTGAGAACCCAAAG
ATCCCACATGGAGAAAGGGAGTTCTGGGAATTGTGTAACAAGTGTAATTTGATGAGACCG
AAGCGTTCCCATCACTGCAGCCGCTGCGGCCACTGTGTTAGGAGAATGGATCATCACTGC
CCATGGATTAACAATTGTGTTGGTGAAGATAACCATTGGCTTTTTCTGCAATTGTGTTTC
TACACTGAACTTCTTACTTGCTACGCACTGATGTTTTCTTTCTGCCACTATTATTACTTT
CTTCCGCTAAAAAAGCGTAATTTGGACCTCTTTGTTGTCAGACATGAATTGGCCATAATG
AGACTAGCTGCCTTTATGGGCATTACAATGTTAGTTGGAATAACTGGACTGTTTTATACT
CAACTAATTGGCATCATCACAGATACAACATCTATTGAAAAGATGTCAAACTGTTGTGAA
GAAATATCGAGGCCCCGAAAGCCATGGCAGCAGACCTTCTCAGAAGTTTTTGGCACTCGT
TGGAAGATCCTGTGGTTTATTCCTTTCAGGCGGAGGCAACCACTGCGAGTTCCCTACCAC
TTTGCCAATCACGTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 265 |
| Molecular Weight
| 31463.0 |
| Theoretical pI
| 8.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 17-37
- 45-65
- 134-154
- 186-206
|
| Protein Sequence
|
>Probable palmitoyltransferase ZDHHC21
MGLRIHFVVDPHGWCCMGLIVFVWLYNFFLIPKIVLFPHYEEGHIPGILIIIFYGIAMFC
LVALVRASITDPGRLPENPKIPHGEREFWELCNKCNLMRPKRSHHCSRCGHCVRRMDHHC
PWINNCVGEDNHWLFLQLCFYTELLTCYALMFSFCHYYYFLPLKKRNLDLFVVRHELAIM
RLAAFMGITMLVGITGLFYTQLIGIITDTTSIEKMSNCCEEISRPRKPWQQTFSEVFGTR
WKILWFIPFRRRQPLRVPYHFANHV
|
| External Links |
|---|
| GenBank ID Protein
| AAI33396.1 |
| UniProtKB/Swiss-Prot ID
| A2VDT6 |
| UniProtKB/Swiss-Prot Entry Name
| ZDH21_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133395 |
| GeneCard ID
| ZDHHC21 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
