| Identification |
|---|
| BMDB Protein ID
| BMDBP00251 |
| Secondary Accession Numbers
| None |
| Name
| Palmitoyltransferase ZDHHC16 |
| Synonyms
|
Not Available
|
| Gene Name
| ZDHHC16 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyltransferase activity |
| Specific Function
| Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| ZDHHC16 |
| Gene Sequence
|
>1086 bp
ATGCGGGGCCAGTGGAGCCTACTGCTGGGCCCTGCCCGCCTTTGCCTGCGCCTGCTTCTG
CTCCTGGGCTACAGGCGCCGCTGCCCACCTCTGCTCCGCGGCCTGGTGCAGCGCTGGCGC
TACGGCAAGGTCTGCCTGCGCTCCCTGCTCTACAACTCCTTCGGGGGCAGTGACACCGCC
GTGGACGCTGCCTTTGAGCCTATCTACTGGCTGGTGGACAACGTGATCCGCTGGTGTGGG
GTGGTGTTCGTGGTGCTGGTGATCGTGCTGACCAGCTCCATCGTGGCCATCGCCTACCTG
TGTGTCCTGCCCCTCATCCTCCAAACCTACTCCGTGCCCCGGCTCTGCTGGCATTTCTTC
TATAGTCACTGGAATCTGATTCTCATCGTCTTCCATTACTACCAGGCTATCACCACCCCA
CCTGGATACCCACCCCAGGGCAGGAATGATATGACAACAGTCTCCATCTGTAAGAAGTGC
ATTAACCCCAAGCCAGCCCGAACACACCACTGCAGCATCTGCAATAGGTGTGTGCTGAAG
ATGGATCATCACTGCCCCTGGCTAAACAACTGTGTGGGCCACTATAACCATCGGTACTTC
TTCTCTTTCTGCTTTTTCATGACCCTGGGCTGTGTCTACTGCAGCTATGGAAGCTGGGAC
CTTTTCCGGGAGGCTTATGCTGCCATCGAGACTTACCATCAGACCCCACCACCCACCTTC
TCCTTCCGAGAAAGAGTGACTCACAAGAGTCTTGTCTACCTCTGGTTCCTGTGCAGTTCT
GTGGCACTTGCCCTGGGTGCCCTAACCATATGGCACGCTGTGCTCATCAGTCGAGGTGAG
ACTAGCATCGAAAGGCACATCAACAAGAAGGAGCGCCAGCGGCTGCAGGCCAAGGGCAGA
GTTTTTAGGAATCATTACAACTATGGTTGCTTGGACAACTGGAAGGTATTCCTGGGTGTG
GACACAGGAAGGCACTGGCTTACTCGGGTGTTGTTACCTTCCAGTCACTTGCCCCATGGG
AACGGAATGAGCTGGGATCCCCCGCCCTGGGTGACTGCTCACTCAGCCTCTGTGATGGCA
GTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 43614.0 |
| Theoretical pI
| 9.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 80-100
- 117-137
- 199-219
- 267-287
|
| Protein Sequence
|
>Probable palmitoyltransferase ZDHHC16
MRGQWSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKVCLRSLLYNSFGGSDTA
VDAAFEPIYWLVDNVIRWCGVVFVVLVIVLTSSIVAIAYLCVLPLILQTYSVPRLCWHFF
YSHWNLILIVFHYYQAITTPPGYPPQGRNDMTTVSICKKCINPKPARTHHCSICNRCVLK
MDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFREAYAAIEKMKQLDKNKL
QAVANQTYHQTPPPTFSFRERVTHKSLVYLWFLCSSVALALGALTIWHAVLISRGETSIE
RHINKKERQRLQAKGRVFRNHYNYGCLDNWKVFLGVDTGRHWLTRVLLPSSHLPHGNGMS
WDPPPWVTAHSASVMAV
|
| External Links |
|---|
| GenBank ID Protein
| AAX46555.1 |
| UniProtKB/Swiss-Prot ID
| Q58CU4 |
| UniProtKB/Swiss-Prot Entry Name
| ZDH16_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021708 |
| GeneCard ID
| ZDHHC16 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
