Showing Protein Propionyl-CoA carboxylase beta chain, mitochondrial (BMDBP00253)
| Identification | |||||||
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| BMDB Protein ID | BMDBP00253 | ||||||
| Secondary Accession Numbers | None | ||||||
| Name | Propionyl-CoA carboxylase beta chain, mitochondrial | ||||||
| Synonyms | Not Available | ||||||
| Gene Name | PCCB | ||||||
| Protein Type | Enzyme | ||||||
| Biological Properties | |||||||
| General Function | Involved in ATP binding | ||||||
| Specific Function | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). | ||||||
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| Reactions |
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| GO Classification | Not Available | ||||||
| Cellular Location | Not Available | ||||||
| Gene Properties | |||||||
| Chromosome Location | 1 | ||||||
| Locus | 1q31-q36 | ||||||
| SNPs | PCCB | ||||||
| Gene Sequence |
>1620 bp ATGGCTGCAGCAATGCGCGTGGCTGTGGCCGGAGCCAGGCTCAGTGTTGTACTGAGAAGT CTCCGGGGCGCGGGGCGCAGCTTGTGCACCCAGCCTGTATCGGTTAACGAACGCATCGAG AACAAGCGGCAAGCTGCACTGCTGGGAGGAGGGCAGCGCCGCATTGACGCGCAGCATAAG CGAGGAAAGCTGACAGCCAGAGAGCGGATCAGTCTCTTGCTGGACCCTGGCAGTTTTGTT GAGAGCGACATGTTTGTGGAACACAGATGTGCAGATTTTGGAATGGCTGCTGATAAGAAT AAGTTCCCTGGAGACAGTGTGGTCACTGGACGAGGACGAATCAATGGAAGACTGGTTTAT GTCTTCAGTCAGGATTTTACAGTTTTTGGAGGTAGCCTGTCTGGAGCACATGCCCAAAAG ATCTGCAAAATCATGGACCAAGCCCTCACAGTGGGGGCTCCAGTGATTGGACTGAATGAC TCTGGAGGTGCACGGATTCAAGAGGGAGTGGAATCTTTGGCTGGCTATGCAGACATCTTT CTGAGGAATGTCACGGCATCCGGAGTCATCCCTCAGATTTCTCTGATCATGGGCCCATGT GCTGGTGGGGCTGTCTACTCCCCAGCCTTAACAGACTTCACGTTCATGGTGAAGGACACC TCCTACTTATTCATCACTGGCCCTGACGTTGTGAAGTCTGTCACCAATGAGGACGTTACT CAGGAGGAACTCGGGGGTGCCAGGACCCACACCACCATGTCAGGTGTGGCCCACAGGGCT TTTGAGAATGACGTTGATGCCTTGTGTAATCTCCGGGAATTCTTCAACTACCTGCCTCTC AGCAATCAGGACCCAGCTCCTGTCCTTGAGTGCCATGACCCCAGTGACCGTCTGGTTCCT GAGCTTGACACAATTGTCCCTTTGGAATCTACCAAAGCCTACAACATGGTGGACATCATA CATGCTGTTGTGGATGAGCGAGAATTTTTTGAGATCATGCCCAATTATGCCAAGAACATC ATTGTTGGTTTTGCAAGAATGAACGGGAGGACTGTTGGAATTGTTGGCAACCAACCTAAG GTGGCTTCAGGCTGCTTGGACATTAATTCTTCTGTGAAAGGGGCTCGTTTCGTCCGATTC TGTGACTCGTTCAACATTCCCCTCATCACTTTTGTGGATGTCCCCGGCTTCCTGCCTGGC ACCGCGCAGGAGTATGGGGGCATCATCCGCCACGGCGCCAAGCTGCTGTACGCGTTTGCA GAGGCCACTGTGCCCAAAGTGACGGTCATCACCAGGAAGGCCTACGGTGGTGCCTATGAT GTCATGAGCTCCAAGCACCTCTGTGGTGACACCAACTACGCCTGGCCCACGGCAGAGATT GCAGTCATGGGAGCAAAGGGTGCTGTGGAGATCATCTTCAAAGGGCACGAGAACGTGGAG GCTGCTCAGGCAGAGTACATCGAGAAGTTTGCCAACCCTTTTCCTGCAGCCGTGAGAGGG TTTGTGGACGACATCATCCAGCCTTCTTCCACACGTGCCCGAATCTGCTGTGACCTGGAT GTCCTGGCCAGCAAGAAGGTACAGCGCCCTTGGAGGAAACATGCGAATATTCCATTGTAA |
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| Protein Properties | |||||||
| Number of Residues | 539 | ||||||
| Molecular Weight | 58311.0 | ||||||
| Theoretical pI | 7.48 | ||||||
| Pfam Domain Function | Not Available | ||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||
| Protein Sequence |
>Propionyl-CoA carboxylase beta chain, mitochondrial MAAAMRVAVAGARLSVVLRSLRGAGRSLCTQPVSVNERIENKRQAALLGGGQRRIDAQHK RGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVY VFSQDFTVFGGSLSGAHAQKICKIMDQALTVGAPVIGLNDSGGARIQEGVESLAGYADIF LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVT QEELGGARTHTTMSGVAHRAFENDVDALCNLREFFNYLPLSNQDPAPVLECHDPSDRLVP ELDTIVPLESTKAYNMVDIIHAVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK VASGCLDINSSVKGARFVRFCDSFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFA EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVE AAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL |
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| External Links | |||||||
| GenBank ID Protein | AAI09785.1 | ||||||
| UniProtKB/Swiss-Prot ID | Q2TBR0 | ||||||
| UniProtKB/Swiss-Prot Entry Name | PCCB_BOVIN | ||||||
| PDB IDs | Not Available | ||||||
| GenBank Gene ID | BC109784 | ||||||
| GeneCard ID | PCCB | ||||||
| GenAtlas ID | Not Available | ||||||
| HGNC ID | Not Available | ||||||
| References | |||||||
| General References | Not Available | ||||||