Identification
BMDB Protein ID BMDBP00261
Secondary Accession Numbers None
Name Squalene synthase
Synonyms Not Available
Gene Name FDFT1
Protein Type Enzyme
Biological Properties
General Function Lipid transport and metabolism
Specific Function Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Pathways
  • Lanosterol biosynthesis
  • Lanosterol from farnesyl diphosphate: step 1/3
  • Steroid Biosynthesis
  • Terpene metabolism
Reactions
2 Farnesyl pyrophosphate + NADPH → Squalene + NADP +2 Pyrophosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 8
Locus Not Available
SNPs FDFT1
Gene Sequence
>1254 bp
ATGGAGTTCGTGAAGTGCTTGGGGCACCCTGAGGAGTTCTACAACCTTCTGCGCTTCCAG
ATGGGGGGCCGACGGAAGGTGATACCCAAAATGGACCAGGACTCGCTCAGCAGCAGCTTG
AAAACATGCTACAAGTACCTGAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCG
CTGGATGGGGAAATGCGCCATGCAGTATGCATATTTTATCTGGTTCTCCGAGCTTTGGAC
ACACTGGAAGATGACATGACTATCAGTATAGAAAGAAAAGTGCCACTGCTACACAACTTC
CACTCATACCTTTATGAGCCTGACTGGCGGTTCACGGAGAGCAAGGAAAAGGACCGACAA
GTCCTGGAGGACTTCCCAACGATCTCCCTGGAGTTTCGAAATCTGGCTGAGAAATATCAG
ACAGTGATTGTTGACGTTTGCCAGAAGATGGGCTTTGGGATGGCGGAGTTTCTGGATAAG
CGCGTGACGTCTGAACGGGAGTGGGACAAGTACTGTCACTATGTTGCTGGTCTAGTGGGA
ATTGGCCTCTCCCGTCTCTTCCCGGCCTCAGAGTTAGAAGACCCCTTAATTGGCGAAGAC
ACAGAGCGAGCCAACTCTATGGGCCTTTTTCTGCAGAAAACAAACATCATCCGTGATTAT
CTGGAAGACCAGCGAGAAGGGAGAGAGTTTTGGCCTCAAGAGACTTGGAGCAAGTATGTG
AAGAAGCTGGGTGACTTTGCTAAGCCAGAGAACATTGACTTGGCTGTGCAGTGTCTGAAT
GAACTCATCACCAACACACTGCACCACATCCCCGACGTCATCACCTACCTGTCACGACTT
AGAAACCAGAGTATTTTTAACTTCTGTGCTATTCCACAGGTCATGGCCATTGCTACTTTG
GCTGCCTGTTACAATAATCAGCAGGTGTTCAAGGGGGTGGTGAAGATTCGAAAAGGGCAA
GCGGTCACCCTGATGATGGATGCCACCAACATGCCAGCTGTAAAAGCCATAATACACCAG
TACATGGAAGAGATTTATCACAGAATTCCCAACTCTGACCCCTGTTCCACTAAAACACAG
CAGATCATCTCCACCATCAGGACACAGAATCTCCCCAACTGTCAGCTGGTCTCGCGGAGC
CACTACTCGCCCATCTACCTGTCGTTCGTCATGCTCCTGGCGGCCCTGAGCTGGCAGTAC
CTGAGCACCCTGTCCCAGGTCACAGAGGACTATGTTCAGACCGGGGAGCACTGA
Protein Properties
Number of Residues 417
Molecular Weight 48304.0
Theoretical pI 6.44
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 284-304
  • 384-404
Protein Sequence
>Squalene synthetase
MEFVKCLGHPEEFYNLLRFQMGGRRKVIPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRHAVCIFYLVLRALDTLEDDMTISIERKVPLLHNFHSYLYEPDWRFTESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIVDVCQKMGFGMAEFLDKRVTSEREWDKYCHYVAGLVG
IGLSRLFPASELEDPLIGEDTERANSMGLFLQKTNIIRDYLEDQREGREFWPQETWSKYV
KKLGDFAKPENIDLAVQCLNELITNTLHHIPDVITYLSRLRNQSIFNFCAIPQVMAIATL
AACYNNQQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIHQYMEEIYHRIPNSDPCSTKTQ
QIISTIRTQNLPNCQLVSRSHYSPIYLSFVMLLAALSWQYLSTLSQVTEDYVQTGEH
GenBank ID Protein AAI09960.1
UniProtKB/Swiss-Prot ID Q32KR6
UniProtKB/Swiss-Prot Entry Name FDFT_BOVIN
PDB IDs
GenBank Gene ID BC109959
GeneCard ID FDFT1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available