| Identification |
|---|
| BMDB Protein ID
| BMDBP00358 |
| Secondary Accession Numbers
| None |
| Name
| Serotonin N-acetyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| AANAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. |
| Pathways
|
- Aromatic compound metabolism
- Melatonin biosynthesis
- Melatonin from serotonin: step 1/2
- Tryptophan Metabolism
|
| Reactions
|
| Serotonin + Acetyl-CoA → N-Acetylserotonin + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| AANAT |
| Gene Sequence
|
>624 bp
ATGTCCACGCCGAGCATCCACTGCCTGAAACCCTCGCCTCTGCACCTGCCGTCTGGGATC
CCAGGGTCCCCAGGCCGCCAGCGGCGCCACACACTCCCCGCCAACGAGTTCCGCTGCCTC
ACCCCAAAGGACGCTGCCGGCGTGTTTGAGATTGAGCGAGAGGCCTTCATCTCTGTCTCC
GGCAACTGCCCCCTGAATCTGGACGAGGTCCGGCACTTCCTAACCCTGTGTCCCGAGCTG
TCCCTGGGCTGGTTCGTGGAGGGCCGCCTCGTGGCCTTCATCATTGGCTCCCTGTGGGAC
GAGGAAAGACTTACTCAGGAGTCGCTGACGCTGCACAGGCCCGGGGGCCGCACGGCCCAC
CTGCATGCGCTGGCCGTGCACCACAGCTTCCGGCAGCAGGGCAAGGGCTCCGTGCTGCTG
TGGCGCTACCTGCAGCACGCGGGCGGCCAGCCGGCCGTGCGCCGGGCCGTGCTCATGTGC
GAGGACGCGCTGGTGCCCTTCTACCAGAGGTTCGGCTTCCATCCCGCGGGCCCGTGTGCC
GTCGTCGTGGGCTCACTGACCTTCACGGAGATGCACTGCTCCCTGCGGGGCCACGCCGCC
CTGCGCCGGAACAGTGACCGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 207 |
| Molecular Weight
| 22997.0 |
| Theoretical pI
| 8.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serotonin N-acetyltransferase
MSTPSIHCLKPSPLHLPSGIPGSPGRQRRHTLPANEFRCLTPKDAAGVFEIEREAFISVS
GNCPLNLDEVRHFLTLCPELSLGWFVEGRLVAFIIGSLWDEERLTQESLTLHRPGGRTAH
LHALAVHHSFRQQGKGSVLLWRYLQHAGGQPAVRRAVLMCEDALVPFYQRFGFHPAGPCA
VVVGSLTFTEMHCSLRGHAALRRNSDR
|
| External Links |
|---|
| GenBank ID Protein
| AAB58942.1 |
| UniProtKB/Swiss-Prot ID
| O02785 |
| UniProtKB/Swiss-Prot Entry Name
| SNAT_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AD000742 |
| GeneCard ID
| AANAT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
