Showing Protein Elongator complex protein 3 (BMDBP00361)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00361 |
| Secondary Accession Numbers | None |
| Name | Elongator complex protein 3 |
| Synonyms | Not Available |
| Gene Name | ELP3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Transcription |
| Specific Function | Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 8 |
| Locus | Not Available |
| SNPs | ELP3 |
| Gene Sequence |
>1644 bp ATGAGGCAGAAGCGCAAAGGCGACCTCAGCCCTGCTCAGCTAATGATGCTGACCATAGGA GATGTTATTAAACAACTAATTGAAGCTCACGAACAGGGGAAAGACATCGATCTAAATAAG GTGAAGACCAGGACAGCTGCCAAATACGGGCTCTCGGCACAGCCCCGCCTGGTGGACATC ATCGCCGCGGTCCCGCCTCAGTATCGGAAGGTCTTGGTCCCCAAGCTGAAGGCGAAACCC ATCAGAACCGCCAGTGGGATTGCTGTTGTGGCTGTCATGTGCAAACCCCACAGATGTCCA CACATCAGTTTTACAGGAAATATATGTGTGTACTGCCCTGGCGGACCTGATTCAGATTTC GAATATTCCACCCAGTCTTACACTGGATATGAGCCAACCTCCATGCGAGCTATCCGTGCC AGGTATGACCCTTACCTGCAGACAAGACACCGGATCGAACAGTTAAAACAGCTTGGTCAC AGTGTGGATAAAGTGGAATTTATCGTGATGGGTGGAACATTTATGGCCCTTCCAGAAGAA TACAGAGATTATTTTATTCGAAATTTACATGATGCCTTATCAGGACATACCTCCAACAAT ATTTATGAGGCCGTCAAGTATTCTGAGAGAAGCCTCACAAAGTGCATCGGAATTACTATT GAGACCAGACCAGATTACTGCATGAAGCGGCATCTCAGTGACATGTTGACCTATGGCTGC ACAAGGCTGGAGATTGGGGTGCAGAGTGTCTATGAGGATGTGGCCAGAGATACCAACCGG GGCCACACTGTGAAGGCAGTGTGCGAGTCCTTCCACCTGGCCAAAGATTCTGGCTTCAAA GTGGTGGCTCACATGATGCCTGATCTGCCGAACGTGGGGCTGGAGAGAGACATTGAACAG TTCACAGAGTTTTTCGAGAACCCAGCTTTCCGTCCTGACGGTTTGAAACTCTACCCTACC CTGGTGATTCGTGGGACAGGGCTCTATGAGCTGTGGAAGTCAGGAAGATACAAGAGTTAT TCCCCCAGCGACCTGATCGAGTTGGTGGCCCGGATCCTGGCCCTCGTGCCCCCGTGGACT CGAGTGTACCGCGTGCAGAGAGATATTCCAATGCCGTTAGTCAGCTCAGGAGTGGAGCAC GGAAACTTGAGAGAGCTGGCATTTGCAAGAATGAAAGACCTTGGAATACAGTGTCGTGAT GTGAGAACCAGAGAGGTGGGAATCCAAGAAATTCATCACAAAGTCCGGCCATACCAGGTT GAATTGGTGAGAAGAGATTATGTTGCAAATGGAGGCTGGGAAACCTTCTTATCGTATGAA GACCCAGATCAGGACATCTTGATTGGCCTCCTGAGATTACGGAAGTGTTCAGAGGAGACA TTCCGTTTCGAATTGGTTGGGGGTGTGTCCATAGTCCGAGAGCTGCACGTGTACGGAAGT GTGGTTCCCGTAAGCAGTCGGGATCCCACTAAATTTCAGCATCAGGGCTTTGGCATGCTG CTGATGGAGGAAGCAGAACGAATAGCCAGAGAAGAACATGGATCTGGGAAAATAGCTGTT ATATCAGGGGTCGGCACCAGGAATTATTACAGAAAGATTGGCTACAGATTGCAAGGTCCA TACATGGTAAAGACGCTAGAATAA |
| Protein Properties | |
| Number of Residues | 547 |
| Molecular Weight | 62331.0 |
| Theoretical pI | 9.02 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Elongator complex protein 3 MRQKRKGDLSPAQLMMLTIGDVIKQLIEAHEQGKDIDLNKVKTRTAAKYGLSAQPRLVDI IAAVPPQYRKVLVPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDF EYSTQSYTGYEPTSMRAIRARYDPYLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEE YRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGC TRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQ FTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLIELVARILALVPPWT RVYRVQRDIPMPLVSSGVEHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHKVRPYQV ELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELVGGVSIVRELHVYGS VVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRKIGYRLQGP YMVKTLE |
| External Links | |
| GenBank ID Protein | AAI05501.2 |
| UniProtKB/Swiss-Prot ID | Q2KJ61 |
| UniProtKB/Swiss-Prot Entry Name | ELP3_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC105500 |
| GeneCard ID | ELP3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |