Showing Protein N-alpha-acetyltransferase 10 (BMDBP00364)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00364 |
| Secondary Accession Numbers | None |
| Name | N-alpha-acetyltransferase 10 |
| Synonyms | Not Available |
| Gene Name | NAA10 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in peptide alpha-N-acetyltransferase activity |
| Specific Function | Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | X |
| Locus | Xq28 |
| SNPs | NAA10 |
| Gene Sequence |
>708 bp ATGAACATCCGCAATGCGAGGCCAGAGGACCTGATGAACATGCAACACTGCAACCTCCTG TGCCTGCCTGAGAACTACCAGATGAAATATTATTTCTACCATGGCCTCTCCTGGCCCCAG CTCTCGTACATCGCTGAGGACGAGAATGGGAAGATCGTGGGGTACGTCCTGGCCAAAATG GAAGAAGACCCGGACGATGTGCCCCATGGACATATCACCTCGCTGGCTGTTAAGCGTTCC CACCGGCGTCTTGGCCTGGCTCAAAAGCTGATGGACCAGGCCTCCCGAGCCATGATTGAG AACTTCAATGCCAAATATGTCTCCCTGCATGTCAGGAAGAGTAACCGGGCAGCTCTGCAC CTCTATTCCAACACGCTCAACTTTCAGATCAGTGAAGTGGAGCCCAAATACTACGCTGAC GGGGAAGATGCATACGCCATGAAGCGGGACCTCACCCAGATGGCCGATGAGCTGAGGCGG CACCTGGAGCTGAAGGAGAAGGGCAGGCACGTGGTACTGGGCTCCATCGAGAACAAGATG GAAGGCAAGGGCAACTCGCTTCCAAGCTCAGGGGAGGCCTGTCGTGAGGAAAAGGGCCTG GTTGCGGAGGACAGCGGTGGTGACAGCAAGGACCTCAGCGAGGTCAGCGAGACCACAGAG AGCACCGACGTTAAGGACAGCTCAGAGGCCTCTGACTCGGCCTCCTAG |
| Protein Properties | |
| Number of Residues | 235 |
| Molecular Weight | 26521.0 |
| Theoretical pI | 5.39 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>N-terminal acetyltransferase complex ARD1 subunit homolog A MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKM EEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKYVSLHVRKSNRAALH LYSNTLNFQISEVEPKYYADGEDAYAMKRDLTQMADELRRHLELKEKGRHVVLGSIENKM EGKGNSLPSSGEACREEKGLVAEDSGGDSKDLSEVSETTESTDVKDSSEASDSAS |
| External Links | |
| GenBank ID Protein | AAI12808.1 |
| UniProtKB/Swiss-Prot ID | Q2KI14 |
| UniProtKB/Swiss-Prot Entry Name | NAA10_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC112807 |
| GeneCard ID | NAA10 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |