| Identification |
|---|
| BMDB Protein ID
| BMDBP00371 |
| Secondary Accession Numbers
| None |
| Name
| Acetyl-CoA acetyltransferase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. |
| Pathways
|
- Butyrate Metabolism
- Fatty Acid Metabolism
- Ketone Body Metabolism
- Lysine Degradation
- Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
- Propanoate Metabolism
- Pyruvate Metabolism
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| 2 Acetyl-CoA → Acetoacetyl-CoA + Coenzyme A |
details
|
| Coenzyme A + Acetoacetyl-CoA →2 Acetyl-CoA |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| ACAT1 |
| Gene Sequence
|
>1269 bp
ATGCCTGTGTTAGCGGCCCTTCTGCGGCGCGGCCCCCTGCTTCAGAGGCGGGTGCAGGAA
ATAAGGTATGCGGAGCGAAGTTATGTATCAAAACCCACTTTGAATGAAGTGGTCATAGTA
AGTGCTATAAGAACACCCATTGGATCCTTTCTAGGCAGTCTTTCCTCTCTGCCAGCCACT
AAACTTGGTTCCATTGCAATTCAGGGAGCCATTGAAAAGGCAGGGATTCCAAAAGAAGAA
GTGAAAGAAGCATACATGGGCAATGTTCTACAAGGAGGTGAAGGACAGGCCCCTACAAGG
CAAGCAGTACTGGGAGCAGGCTTACCTATTTCTACTCCATGTACCACTATAAACAAAGTT
TGTGCCTCAGGAATGAAAGCCATCATGATGGCCTCTCAGAATCTTATGTGTGGACATCAG
GATGTGATGGTGGCAGGTGGCATGGAGAGCATGTCCAATGTCCCCTATGTAATGAACAGA
GGAGCAACACCATATGGTGGGGTAAAGCTTGAAGATTTGATTGTAAAAGATGGACTAACT
GATGTCTACAATAAAATTCATATGGGCAACTGTGCTGAAAATACTGCAAAGAAGCTGAAT
ATTACACGAGAGGAACAGGATACTTATGCTCTTAATTCCTATACCAGAAGTAAAGCAGCA
TGGGAAGCTGGAAGATTTGGAAATGAAGTTGTTCCTGTCACAATTACAGTAAAAGGTAAA
CCAGATGTAGTGGTGAAAGAAGATGAAGAATATAAACGTGTTGATTTTAGCAAAATTCCA
AAGCTGAAGACAGTTTTCCAAAGAGAAAATGGTACAGTAACAGCTGCCAATGCCAGCACA
CTGAATGATGGAGCAGCTGCTGTGGTTCTGATGACTGCAGATGCAGCTAAGAGGCTCAAT
GTTAAACCACTGGCAAGAATAGCAGCATTTGCTGATGCTGCTGTAGAACCTATTGATTTT
CCACTTGCGCCTGCATATGCTGTTCCTAAGGTTCTTAAAGATGCAGGTTTGAAAAAAGAA
GATATTACTATGTGGGAAGTAAATGAAGCCTTTAGTGTGGTCGTACTAGCAAACATTAAA
ATGCTAGAGATGGATCCCCAAAAAGTGAATATCAACGGAGGAGCTGTTTCTCTTGGACAT
CCAATTGGGATGTCTGGAGCCAGAATTGTCGTCCATTTGGCTCATGCACTGAAGCAAGGA
GAATATGGTCTTGCCAGTATTTGCAACGGAGGAGGAGGTGCTTCTGCCATGCTGATCCAA
AAGCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 422 |
| Molecular Weight
| 44889.0 |
| Theoretical pI
| 9.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acetyl-CoA acetyltransferase, mitochondrial
MPVLAALLRRGPLLQRRVQEIRYAERSYVSKPTLNEVVIVSAIRTPIGSFLGSLSSLPAT
KLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKV
CASGMKAIMMASQNLMCGHQDVMVAGGMESMSNVPYVMNRGATPYGGVKLEDLIVKDGLT
DVYNKIHMGNCAENTAKKLNITREEQDTYALNSYTRSKAAWEAGRFGNEVVPVTITVKGK
PDVVVKEDEEYKRVDFSKIPKLKTVFQRENGTVTAANASTLNDGAAAVVLMTADAAKRLN
VKPLARIAAFADAAVEPIDFPLAPAYAVPKVLKDAGLKKEDITMWEVNEAFSVVVLANIK
MLEMDPQKVNINGGAVSLGHPIGMSGARIVVHLAHALKQGEYGLASICNGGGGASAMLIQ
KL
|
| External Links |
|---|
| GenBank ID Protein
| AAI13329.1 |
| UniProtKB/Swiss-Prot ID
| Q29RZ0 |
| UniProtKB/Swiss-Prot Entry Name
| THIL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC113328 |
| GeneCard ID
| ACAT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
