Showing Protein Acetyl-CoA acetyltransferase, mitochondrial (BMDBP00371)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 metabolites
Identification
BMDB Protein ID BMDBP00371
Secondary Accession Numbers None
Name Acetyl-CoA acetyltransferase, mitochondrial
Synonyms Not Available
Gene Name ACAT1
Protein Type Enzyme
Biological Properties
General Function Lipid transport and metabolism
Specific Function This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
Pathways
  • Butyrate Metabolism
  • Fatty Acid Metabolism
  • Ketone Body Metabolism
  • Lysine Degradation
  • Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
  • Propanoate Metabolism
  • Pyruvate Metabolism
  • Valine, Leucine, and Isoleucine Degradation
Reactions
2 Acetyl-CoA → Acetoacetyl-CoA + Coenzyme A details
Coenzyme A + Acetoacetyl-CoA →2 Acetyl-CoA details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus Not Available
SNPs ACAT1
Gene Sequence 
>1269 bp
ATGCCTGTGTTAGCGGCCCTTCTGCGGCGCGGCCCCCTGCTTCAGAGGCGGGTGCAGGAA
ATAAGGTATGCGGAGCGAAGTTATGTATCAAAACCCACTTTGAATGAAGTGGTCATAGTA
AGTGCTATAAGAACACCCATTGGATCCTTTCTAGGCAGTCTTTCCTCTCTGCCAGCCACT
AAACTTGGTTCCATTGCAATTCAGGGAGCCATTGAAAAGGCAGGGATTCCAAAAGAAGAA
GTGAAAGAAGCATACATGGGCAATGTTCTACAAGGAGGTGAAGGACAGGCCCCTACAAGG
CAAGCAGTACTGGGAGCAGGCTTACCTATTTCTACTCCATGTACCACTATAAACAAAGTT
TGTGCCTCAGGAATGAAAGCCATCATGATGGCCTCTCAGAATCTTATGTGTGGACATCAG
GATGTGATGGTGGCAGGTGGCATGGAGAGCATGTCCAATGTCCCCTATGTAATGAACAGA
GGAGCAACACCATATGGTGGGGTAAAGCTTGAAGATTTGATTGTAAAAGATGGACTAACT
GATGTCTACAATAAAATTCATATGGGCAACTGTGCTGAAAATACTGCAAAGAAGCTGAAT
ATTACACGAGAGGAACAGGATACTTATGCTCTTAATTCCTATACCAGAAGTAAAGCAGCA
TGGGAAGCTGGAAGATTTGGAAATGAAGTTGTTCCTGTCACAATTACAGTAAAAGGTAAA
CCAGATGTAGTGGTGAAAGAAGATGAAGAATATAAACGTGTTGATTTTAGCAAAATTCCA
AAGCTGAAGACAGTTTTCCAAAGAGAAAATGGTACAGTAACAGCTGCCAATGCCAGCACA
CTGAATGATGGAGCAGCTGCTGTGGTTCTGATGACTGCAGATGCAGCTAAGAGGCTCAAT
GTTAAACCACTGGCAAGAATAGCAGCATTTGCTGATGCTGCTGTAGAACCTATTGATTTT
CCACTTGCGCCTGCATATGCTGTTCCTAAGGTTCTTAAAGATGCAGGTTTGAAAAAAGAA
GATATTACTATGTGGGAAGTAAATGAAGCCTTTAGTGTGGTCGTACTAGCAAACATTAAA
ATGCTAGAGATGGATCCCCAAAAAGTGAATATCAACGGAGGAGCTGTTTCTCTTGGACAT
CCAATTGGGATGTCTGGAGCCAGAATTGTCGTCCATTTGGCTCATGCACTGAAGCAAGGA
GAATATGGTCTTGCCAGTATTTGCAACGGAGGAGGAGGTGCTTCTGCCATGCTGATCCAA
AAGCTGTAG
Protein Properties
Number of Residues 422
Molecular Weight 44889.0
Theoretical pI 9.21
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Acetyl-CoA acetyltransferase, mitochondrial
MPVLAALLRRGPLLQRRVQEIRYAERSYVSKPTLNEVVIVSAIRTPIGSFLGSLSSLPAT
KLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKV
CASGMKAIMMASQNLMCGHQDVMVAGGMESMSNVPYVMNRGATPYGGVKLEDLIVKDGLT
DVYNKIHMGNCAENTAKKLNITREEQDTYALNSYTRSKAAWEAGRFGNEVVPVTITVKGK
PDVVVKEDEEYKRVDFSKIPKLKTVFQRENGTVTAANASTLNDGAAAVVLMTADAAKRLN
VKPLARIAAFADAAVEPIDFPLAPAYAVPKVLKDAGLKKEDITMWEVNEAFSVVVLANIK
MLEMDPQKVNINGGAVSLGHPIGMSGARIVVHLAHALKQGEYGLASICNGGGGASAMLIQ
KL
GenBank ID Protein AAI13329.1
UniProtKB/Swiss-Prot ID Q29RZ0
UniProtKB/Swiss-Prot Entry Name THIL_BOVIN
PDB IDs Not Available
GenBank Gene ID BC113328
GeneCard ID ACAT1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available