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Showing Protein Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (BMDBP00374)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 5 metabolites
Identification
BMDB Protein ID BMDBP00374
Secondary Accession Numbers None
Name Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Synonyms Not Available
Gene Name MTHFD2
Protein Type Enzyme
Biological Properties
General Function Coenzyme transport and metabolism
Specific Function Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
Pathways
  • Folate Metabolism
Reactions
5,10-Methenyltetrahydrofolic acid + NADH → 5,10-Methylene-THF + NAD details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 11
Locus Not Available
SNPs MTHFD2
Gene Sequence 
>1053 bp
ATGGCCGCAGCCTCCTTTATAACCTCTTTGGTCACCCGACTGCTCCGGTCCGCGCAGAGT
GGCCGCCTCCATCAACGCCCTTTCCACCTCTCGGCAGTGCGAAATGAAGCTGTTGTCATT
TCTGGAAGGAAACTTGCTGAGCAGATCAAGCAGGAAGTGCGGCAGGAGGTGGAAGAGTGG
GTGGCGTCAGGCAACAAGCGGCCACACCTGAGCGTGGTTCTGGTTGGAGAGAATCCTGCG
AGTCAGTCCTACGTCCTCAACAAAACCAGAGCAGCTGCCAGCGTGGGAATCAACAGTGAG
ACCATTCTGAAACCAGCTTCAATTTCAGAGGAAGAACTGTTGAATTTGATCAATAAACTA
AATAATGATGATAATGTAGACGGCCTCCTTGTTCAGCTGCCTCTTCCAGAGCACATCGAT
GAGAGAAAGGTCTGCAATGCTGTTTCTCCAGACAAAGATGTCGATGGCTTTCATGTAATT
AATGTAGGGCGAATGTGTTTGGACCAGTGTTCCATGTTACCAGCTACTCCATGGGGTGTG
TGGGAAATAATTAAGCGAACTGGCATTCCAACCCTAGGGAAGAATGTGGTTGTGGCCGGA
AGGTCAAAAAATGTTGGAATGCCCATTGCAATGTTGCTGCACACAGATGGGGCACATGAA
CGGCCCGGAGGCGATGCCACTGTCACAATATCTCATCGATACACTCCTAAGGAGGAGCTA
AAGAAACATACAGCTCTTGCAGATATTGTGATCTCCGCTGCAGGTATTCCAAATCTGATC
ACAGCAGATATGATCAAGGAAGGAGCAGCTGTCATTGATGTGGGAATAAATAGAATTCAA
GATCCCATAACTGCTAAACCCAAGTTGGTTGGAGATGTGGATTTTGAAGGAGTCAAGAAG
AAAGCAGGTTACATCACTCCAGTCCCTGGGGGTGTTGGTCCCATGACTGTGGCAATGCTG
ATGAAGAATACCATTATTGCTGCAAAAAAAGTGCTGAGGCTCGAAGAGCAGGAAGTACTG
AAGTCTAAGGAACTTGGAGTAGCAAGTAATTGA
Protein Properties
Number of Residues 350
Molecular Weight 37767.0
Theoretical pI 8.81
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
MAAASFITSLVTRLLRSAQSGRLHQRPFHLSAVRNEAVVISGRKLAEQIKQEVRQEVEEW
VASGNKRPHLSVVLVGENPASQSYVLNKTRAAASVGINSETILKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQCSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEEL
KKHTALADIVISAAGIPNLITADMIKEGAAVIDVGINRIQDPITAKPKLVGDVDFEGVKK
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEQEVLKSKELGVASN
GenBank ID Protein AAI20250.1
UniProtKB/Swiss-Prot ID Q0P5C2
UniProtKB/Swiss-Prot Entry Name MTDC_BOVIN
PDB IDs Not Available
GenBank Gene ID BC120249
GeneCard ID MTHFD2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available