| Identification |
|---|
| BMDB Protein ID
| BMDBP00376 |
| Secondary Accession Numbers
| |
| Name
| Sulfotransferase 1A1 |
| Synonyms
|
Not Available
|
| Gene Name
| SULT1A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in aryl sulfotransferase activity |
| Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| Phosphoadenosine phosphosulfate + Phenol → Adenosine 3',5'-diphosphate + Phenol sulphate |
details
|
| Phosphoadenosine phosphosulfate + Dehydroepiandrosterone → Adenosine 3',5'-diphosphate + DHEA sulfate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| SULT1A1 |
| Gene Sequence
|
>885 bp
ATGGAACTGATCCAGGATACCTCCCGCCCTCCAGCAAAGTATGTGAAGGGCATCCCTCTC
ATCAAGTACTTTGCAGAGGCCCTGGGGCCACTGGAGAGCTTTGAAGCCTGGCCTGATGAC
TTGCTCATCAGCACCTACCCCAAGTCGGGCACCACCTGGGTAAGCGAGATCCTGGACCTG
ATCTACCAGGAGGGTGACCTGGAGAAGTGTCAGAGAGCCCCTGTCTTCTTGCGGGTGCCC
TTCCTTGAGTTCAGCGCCCCTGGGGTTCCCACAGGTGTTGAGCTTCTGAAAGATACACCA
GCCCCACGGCTCCTCAAGACACACTTGCCTCTGGCCCTGCTTCCGAAGACCCTGCTGGAT
CAGAAAGTCAAGGTGATCTACATCGCCCGCAACGCCAAGGATGTGGCCGTCTCCTATTAC
CACTTCTATCGCATGGCCAAGGTGCACCCTGACCCTGGCACCTGGGACAGCTTCCTGGAG
AAGTTCATGGCCGGGGAAGTGTGCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGGTGG
GAGCTGAGTCACACCCACCCTGTTCTCTACCTCTTCTACGAGGACATAAAGGAGGACCCC
AAAAGGGAGATTCAGAAGATCCTGGAGTTTATAGGGCGCTCCCTGCCTGAGGAGACTGTG
GATCACATTGTCCAGCGCACATCTTTCAAAGAGATGAAGAAGAACCCCATGACCAACTAC
AGCACCATACCCACTGCAGTCATGGACCACAGCATCTCTGCCTTCATGAGGAAAGGCATC
ACTGGTGATTGGAAATCCACCTTCACTGTGGCCCAGAATGAGCTCTTTGAAGCCCACTAT
GCTAAGAAGATGCGGGCTGCAACTCCGCTTCGCTGGGAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 34184.0 |
| Theoretical pI
| 7.02 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sulfotransferase 1A1
MELIQDTSRPPAKYVKGIPLIKYFAEALGPLESFEAWPDDLLISTYPKSGTTWVSEILDL
IYQEGDLEKCQRAPVFLRVPFLEFSAPGVPTGVELLKDTPAPRLLKTHLPLALLPKTLLD
QKVKVIYIARNAKDVAVSYYHFYRMAKVHPDPGTWDSFLEKFMAGEVCYGSWYQHVQEWW
ELSHTHPVLYLFYEDIKEDPKREIQKILEFIGRSLPEETVDHIVQRTSFKEMKKNPMTNY
STIPTAVMDHSISAFMRKGITGDWKSTFTVAQNELFEAHYAKKMAGCKLRFRWEL
|
| External Links |
|---|
| GenBank ID Protein
| AAA85510.1 |
| UniProtKB/Swiss-Prot ID
| P50227 |
| UniProtKB/Swiss-Prot Entry Name
| ST1A1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U35253 |
| GeneCard ID
| SULT1A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
