Showing Protein Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (BMDBP00377)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00377 |
| Secondary Accession Numbers | None |
| Name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 |
| Synonyms | Not Available |
| Gene Name | NDST2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in [heparan sulfate]-glucosamine N-sulfotransf |
| Specific Function | Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 28 |
| Locus | Not Available |
| SNPs | NDST2 |
| Gene Sequence |
>2655 bp ATGCTCAAGCTGTGGAAGGTGGTACGCCCAGCTCGGCAGTTGGAACTGCACCGCCTCATA CTGCTGCTGATTGCTTTCAGTCTGGGCTCCATGGGCTTCTTGGCTTACTACGTATCCACC AGCCCCAAGGCCAAGGAACCGTTGCCVCTCCCCTTGGGAGACTGCAGCAGTAGTGGCGCA GCGGGTGGTCCTGGCCCGGTTCGGCCTCCAGTCCCACCACGCCCCCCCAGGCCTCCAGAG ACAGCGCGAACTGAACCCGTGGTCCTTGTGTTTGTGGAGAGTGCATACTCGCAGCTGGGG CAGGAGATCGTGGCCATCTTGGAGTCTAGCCGTTTTCGTTACAGCACTGAGCTGGCACCT GGCCGAGGGGACATGCCCACACTGACGGATCATACCCGGGGCCGGTATGTCTTGGTCATT TATGAGAACCTGCTCAAGTACGTCAACCTGGATGCCTGGAGTCGGGAACTGCTAGACCGG TACTGTGTGGAGTACGGTGTAGGCATCATTGGCTTTTTTCGAGCCCATGAGCACAGCCTA CTGAGTGCCCAGCTCAAGGGCTTTCCCCTTTTTCTCCATTCAAACTTGGGGCTTCGGGAC TACCAAGTGAATCCTACAGCTCCACTCCTACATCTCACACGTCCCAGCCGCCTGGAGCCT GGGCCACTACCCGGTGATGACTGGACCATCTTCCAATCCAACCACAGGACCTATGAACCA GTGCTTCTTGGCAGCCTTCGGCCGGCTGAGCCCCCTGTGCCAGGACCAGTGGCTCGGCGG GCCCGGCTTCCCACTGTGGTGCAGGACCTGGGGGTTCACGATGGAATCCAGAGGGTGCTG TTTGGGCACGGGCTCTCCTTCTGGCTCCACAAACTAGTTTTCCGCGATGCCGGTGGGTAC CTCACTGGCAAGGGGCTCTTGTGGGACTTGGACCGTTACATCTTGGTAGACATCGATGAC ATCTTTGTGGGCAAGGAAGGTACCCGCATGAAGGTGGCTGATGTTGAGGCCCTGTTGACC ACGCAGAACAAACTCAGGACCTTAGTCCCCAACTTCACCTTCAACTTGGGCTTCTCGGGC AAGTTCTATCATACTGGGACAGAGGAGGAGGATGCTGGGGACGACATGCTGCTGAATCAC CGCCGAGAGTTCTGGTGGTTCCCCCACATGTGGAGCCACATGCAGCCACATCTGTTCCAC AATCGCTCCGTGCTGGCTGACCAGATGAGGCTCAACAAACAGTTTGCTCTGGAACATGGG ATTCCCACGGATCTGGGGTATGCTGTGGCCCCCCACCACTCCGGCGTGTACCCCATCCAC ACACAGCTCTATGAAGCCTGGAAATCTGTGTGGGGCATCCAGGTGACCAGCACTGAGGAG TACCCCCACCTCCGCCCTGCCCGCTACCGCCGCGGCTTCATTCACAATGGCATTATGGTG CTGCCGCGGCAGACATGTGGCCTCTTCACTCACACAATCTTCTATAATGAGTATCCAGGA GGCTCTCGTGAACTCGACCGGAGTATCCGAGGTGGAGAACTCTTTCTGACAGTGCTGCTT AATCCGATCAGCATCTTTATGACTCATCTGTCGAACTATGGAAATGATCGCCTGGGTCTG TACACCTTTGAGAGCCTGGTGCGCTTTCTCCAGTGCTGGACGAGCCTGCGCCTACAGACC CTTCCTCCTGTCCCTCTTGGGCGAAAGTACTTTGACCTCTTCCCTCAAGAGCGAAGCCCC CTTTGGCAGAATCCCTGTGACGACAAGAGGCACAAAGATATCTGGTCCAAGGAGAAAACC TGTGATCGCCTCCCCAAGTTCCTCATTGTGGGACCCCAGAAGACAGGGACCACAGCTATT CACTTCTTCCTGAGCCTGCATCCAGCTGTGACTAGCAGTTTTCCTAGCCCCAGCACCTTT GAGGAGATTCAGTTCTTCAACGGCCCTAATTACCACAAGGGCATTGACTGGTACATGGAT TTCTTCCCTGTCCCTTCCAATGCCAGCACTGATTTCCTATTTGAAAAAAGTGCCACGTAC TTTGACTCAGAGGTTGTACCACGGCGGGGAGCTGCCCTCCTGCCACGAGCCAAGATCATC ACTGTGCTCACCAACCCTGCTGACAGGGCATACTCCTGGTACCAGCATCAGCGAGCACAT GGAGACCCAGTTGCTCTGAACTACACCTTCTACCAGGTGATTACAGCCTCCTCCCAGGAC CCTCCAGCACTTCGCTCCCTACAAAACCGTTGTCTTGTCCCCGGCTACTATTCCACTCAC TTACAACGCTGGCTGACTTACTACCCCTCTGGACAGTTGCTGATTGTGGATGGGCAAGAG CTGCGTACCAACCCAGCTGCCTCAATGGAGATCATCCAGAAGTTCCTGGGTATCACACCC TTTCTGAACTACACACGGACCCTCAGGTTCGATGAAGATAAGGGATTCTGGTGCCAGGGA CTTGAAGGTGGCAAGACTCGTTGTCTAGGAAAGAGCAAAGGTCGGAAGTACCCAGATATG GACGCTGAGTCCCGCCTTTTCCTTACGGATTTTTTCCGGAACCACAATTTGGAGCTGTCA AAGCTGCTGAGCCGGCTTGGACAGCCAGTGCCCTCATGGCTTCGAGAAGAACTGCAGCAT TCCAGTTCGGGCTGA |
| Protein Properties | |
| Number of Residues | 884 |
| Molecular Weight | 100897.0 |
| Theoretical pI | 8.94 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 MLKLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSSGA AGGPGPVRPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAP GRGDMPTLTDHTRGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSL LSAQLKGFPLFLHSNLGLRDYQVNPTAPLLHLTRPSRLEPGPLPGDDWTIFQSNHRTYEP VLLGSLRPAEPPVPGPVARRARLPTVVQDLGVHDGIQRVLFGHGLSFWLHKLVFRDAGGY LTGKGLLWDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSG KFYHTGTEEEDAGDDMLLNHRREFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHG IPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMV LPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGL YTFESLVRFLQCWTSLRLQTLPPVPLGRKYFDLFPQERSPLWQNPCDDKRHKDIWSKEKT CDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNGPNYHKGIDWYMD FFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAH GDPVALNYTFYQVITASSQDPPALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQE LRTNPAASMEIIQKFLGITPFLNYTRTLRFDEDKGFWCQGLEGGKTRCLGKSKGRKYPDM DAESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSSG |
| External Links | |
| GenBank ID Protein | AAC77921.1 |
| UniProtKB/Swiss-Prot ID | O97583 |
| UniProtKB/Swiss-Prot Entry Name | NDST2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF064825 |
| GeneCard ID | NDST2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |