Showing Protein Sulfotransferase 1E1 (BMDBP00378)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00378 | ||
| Secondary Accession Numbers | None | ||
| Name | Sulfotransferase 1E1 | ||
| Synonyms | Not Available | ||
| Gene Name | SULT1E1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in estrone sulfotransferase activity | ||
| Specific Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 6 | ||
| Locus | Not Available | ||
| SNPs | SULT1E1 | ||
| Gene Sequence |
>888 bp ATGAGTTCTTCCAAACCATCCTTTTCAGATTACTTTGGCAAACTTGGTGGAATACCAATG TATAAAAAATTTATCGAGCAGTTTCATAACGTGGAGGAATTTGAGGCAAGACCAGATGAC CTTGTCATTGTCACCTATCCCAAATCTGGTACAACATGGCTTAGTGAAATTATATGCATG ATTTATAATAACGGTGATGTGGAAAAGTGCAAAGAAGACGTCATTTTTAATAGAGTTCCT TACCTGGAATGTAGCACTGAACACGTGATGAAAGGAGTGAAACAATTAAATGAGATGGCA TCTCCTAGAATAGTGAAGTCTCACCTGCCTGTGAAGCTTCTTCCAGTCTCATTTTGGGAA AAGAACTGTAAGATCATCTATCTTTCCCGGAATGCCAAGGATGTGGTTGTTTCTTATTAT TTTTTAATTTTAATGGTGACTGCTATTCCAGATCCTGACTCTTTTCAAGATTTTGTGGAG AAATTCATGGATGGAGAAGTTCCTTATGGTTCCTGGTTTGAACATACAAAATCTTGGTGG GAAAAGAGCAAGAATCCGCAAGTGCTATTTCTTTTCTATGAAGACATGAAGGAGAATATC AGAAAAGAGGTGATGAAATTGTTAGAATTTCTGGGAAGGAAGGCATCAGATGAGCTTGTG GACAAGATTATAAAACACACTTCATTCCAGGAGATGAAGAACAATCCATCTACCAATTAT ACAACATTGCCGGATGAAGTCATGAACCAAAAAGTATCTCCCTTCATGAGAAAAGGAGAT GTAGGAGACTGGAAGAATCACTTTACAGTAGCCCTGAATGAGAAATTTGACATGCACTAT GAGCAGCAAATGAAGGGGTCTACCCTGAAGTTCCGAACTAAGATCTAG |
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| Protein Properties | |||
| Number of Residues | 295 | ||
| Molecular Weight | 34640.0 | ||
| Theoretical pI | 7.18 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Estrogen sulfotransferase MSSSKPSFSDYFGKLGGIPMYKKFIEQFHNVEEFEARPDDLVIVTYPKSGTTWLSEIICM IYNNGDVEKCKEDVIFNRVPYLECSTEHVMKGVKQLNEMASPRIVKSHLPVKLLPVSFWE KNCKIIYLSRNAKDVVVSYYFLILMVTAIPDPDSFQDFVEKFMDGEVPYGSWFEHTKSWW EKSKNPQVLFLFYEDMKENIRKEVMKLLEFLGRKASDELVDKIIKHTSFQEMKNNPSTNY TTLPDEVMNQKVSPFMRKGDVGDWKNHFTVALNEKFDMHYEQQMKGSTLKFRTKI |
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| External Links | |||
| GenBank ID Protein | AAA30679.1 | ||
| UniProtKB/Swiss-Prot ID | P19217 | ||
| UniProtKB/Swiss-Prot Entry Name | ST1E1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | M54942 | ||
| GeneCard ID | SULT1E1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||