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Identification |
BMDB Protein ID
| BMDBP00378 |
Secondary Accession Numbers
| None |
Name
| Sulfotransferase 1E1 |
Synonyms
|
Not Available
|
Gene Name
| SULT1E1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in estrone sulfotransferase activity |
Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). |
Pathways
|
- Androgen and Estrogen Metabolism
- Estrone Metabolism
- Sulfate/Sulfite Metabolism
|
Reactions
|
Estrone + Phosphoadenosine phosphosulfate → Estrone sulfate + Adenosine 3',5'-diphosphate |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| Not Available |
SNPs
| SULT1E1 |
Gene Sequence
|
>888 bp
ATGAGTTCTTCCAAACCATCCTTTTCAGATTACTTTGGCAAACTTGGTGGAATACCAATG
TATAAAAAATTTATCGAGCAGTTTCATAACGTGGAGGAATTTGAGGCAAGACCAGATGAC
CTTGTCATTGTCACCTATCCCAAATCTGGTACAACATGGCTTAGTGAAATTATATGCATG
ATTTATAATAACGGTGATGTGGAAAAGTGCAAAGAAGACGTCATTTTTAATAGAGTTCCT
TACCTGGAATGTAGCACTGAACACGTGATGAAAGGAGTGAAACAATTAAATGAGATGGCA
TCTCCTAGAATAGTGAAGTCTCACCTGCCTGTGAAGCTTCTTCCAGTCTCATTTTGGGAA
AAGAACTGTAAGATCATCTATCTTTCCCGGAATGCCAAGGATGTGGTTGTTTCTTATTAT
TTTTTAATTTTAATGGTGACTGCTATTCCAGATCCTGACTCTTTTCAAGATTTTGTGGAG
AAATTCATGGATGGAGAAGTTCCTTATGGTTCCTGGTTTGAACATACAAAATCTTGGTGG
GAAAAGAGCAAGAATCCGCAAGTGCTATTTCTTTTCTATGAAGACATGAAGGAGAATATC
AGAAAAGAGGTGATGAAATTGTTAGAATTTCTGGGAAGGAAGGCATCAGATGAGCTTGTG
GACAAGATTATAAAACACACTTCATTCCAGGAGATGAAGAACAATCCATCTACCAATTAT
ACAACATTGCCGGATGAAGTCATGAACCAAAAAGTATCTCCCTTCATGAGAAAAGGAGAT
GTAGGAGACTGGAAGAATCACTTTACAGTAGCCCTGAATGAGAAATTTGACATGCACTAT
GAGCAGCAAATGAAGGGGTCTACCCTGAAGTTCCGAACTAAGATCTAG
|
Protein Properties |
Number of Residues
| 295 |
Molecular Weight
| 34640.0 |
Theoretical pI
| 7.18 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Estrogen sulfotransferase
MSSSKPSFSDYFGKLGGIPMYKKFIEQFHNVEEFEARPDDLVIVTYPKSGTTWLSEIICM
IYNNGDVEKCKEDVIFNRVPYLECSTEHVMKGVKQLNEMASPRIVKSHLPVKLLPVSFWE
KNCKIIYLSRNAKDVVVSYYFLILMVTAIPDPDSFQDFVEKFMDGEVPYGSWFEHTKSWW
EKSKNPQVLFLFYEDMKENIRKEVMKLLEFLGRKASDELVDKIIKHTSFQEMKNNPSTNY
TTLPDEVMNQKVSPFMRKGDVGDWKNHFTVALNEKFDMHYEQQMKGSTLKFRTKI
|
External Links |
GenBank ID Protein
| AAA30679.1 |
UniProtKB/Swiss-Prot ID
| P19217 |
UniProtKB/Swiss-Prot Entry Name
| ST1E1_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| M54942 |
GeneCard ID
| SULT1E1 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |