| Identification |
|---|
| BMDB Protein ID
| BMDBP00386 |
| Secondary Accession Numbers
| None |
| Name
| Threonine--tRNA ligase 1, cytoplasmic |
| Synonyms
|
Not Available
|
| Gene Name
| TARS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. |
| Pathways
|
- Protein Synthesis: Threonine
|
| Reactions
|
| Adenosine triphosphate + L-Threonine + tRNA(Thr) → Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| TARS1 |
| Gene Sequence
|
>2172 bp
ATGTCCGAGGAGCAGGCCAGTAGCCCTTCAGCGAAAATGGGAGACGAGGAGAAGCCGGTA
GGTGCTGGTGAAGAGAAACAAAAGGAAGGAAGCAAGAAGAAGAATAAAGAAGGATCGGGG
GATGGAGGTCGAGCAGAGTTGAATCCTTGGCCCGAATATATTAACACCCGTCTTGAGATG
TACAATAAGCTAAAAGCAGAACATGATTCCATTCTGGCAGAAAAGGCAGAAAAAGATAGT
AAGCCCATTAAAGTCACCCTGCCTGATGGTAAACAGGTAGATGCAGAATCCTGGAAAACT
ACACCATATCAAATTGCTTGTGGAATTAGTCAAGGCCTGGCCGACAACACTGTCATTGCT
AAGGTGAATAAAGCCGTCTGGGACCTAGACCGTCCTCTGGAGGAAGATTGCACCTTGGAG
CTGCTCAAGTTTGAGGATGAGGAAGCTCAAGCAGTGTATTGGCACTCAAGTGCTCACATA
ATGGGTGAAGCCATGGAAAGAGTCTATGGTGGGTGTCTGTGTTATGGACCACCAATAGAA
AACGGATTCTATTACGACATGTACCTCGAAGAAGGGGGTGTGTCCAGCAATGATTTCTCT
TCTTTGGAGACTTTATGTAAGAAAATCATTAAAGAAAAGCAAGCTTTCGAAAGATTAGAA
GTTAAGAAGGAAACTTTACTGGAAATGTTTAAGTACAACAAGTTCAAATGCAGGATTTTG
AATGAAAAAGTGAATACTCCAACTACCACAGTCTATAGATGTGGCCCCTTGATAGATCTC
TGCCGGGGTCCTCATGTCAGACACACTGGCAAAATCAAGACTTTGAAAATACACAAAAAT
TCCTCCACCTACTGGGAAGGCAAGTCAGATATGGAGACTCTACAGAGAATTTACGGCATT
TCCTTTCCAGATCCTAAGATGTTGAAAGAATGGGAGAAGTTCCAAGAGGAGGCTAAAAAC
CGAGATCATAGGAAAATTGGAAGGGACCAAGAACTCTACTTCTTCCATGAACTCAGCCCT
GGGAGTTGCTTTTTCCTGCCCAAGGGAGCCTACATTTATAACACACTTATTGAATTCATC
AGGAGTGAATACAGGAAACGAGGATTCCAGGAGGTGGTCACCCCGAACATCTATAATAGC
CGGCTCTGGGTGACCTCGGGCCACTGGGAGCACTACAGCGAGAACATGTTCTCCTTTGAA
GTGGAAAAGGAGCTGTTTGCTCTGAAACCCATGAACTGCCCGGGACACTGCCTCATGTTT
GACCATCGGCCAAGATCCTGGCGAGAGTTGCCTCTGCGAGTTGCTGATTTTGGGGTGCTT
CATAGGAATGAGCTGTCAGGAGCACTCACAGGACTTACTCGGGTCCGAAGGTTCCAGCAA
GATGATGCGCATATATTCTGTGCCATGGAGCAGATTGAGGATGAAATAAAAGGTTGTTTG
GATTTTCTGCGTACAGTATATAGCATATTTGGATTTTCTTTTAAACTGAACCTGTCTACT
CGCCCAGAAAAATTCCTTGGAGATATTGAAGTATGGAATCAAGCTGAGAAACAACTTGAA
AACAGTCTGAATGACTTTGGTGAAAAGTGGGAATTAAATCCCGGAGATGGAGCTTTCTAT
GGTCCAAAGATTGACATCCAGATTAAAGACGCTATTGGGCGGTACCACCAGTGTGCAACA
ATACAGTTGGATTTTCAGTTGCCCATTAGATTTAATCTTACTTTTGTAAGCCATGATGGT
GATGATAAGAAAAAGCCAGTCATTATCCATAGAGCCATCTTGGGGTCAGTGGAAAGAATG
ATTGCTATCCTCACTGAAAACTACGGGGGCAAATGGCCCTTCTGGCTGTCCCCTCGTCAG
GTAATGGTAGTTCCAGTGGGACCAACATGTGATGAATATGCCCAAAAGGTACGGCAACAA
TTCCACAATGCTAAATTCATGGTGGACATTGATCTGGATCCAGGCTGTACATTAAACAAG
AAGATCAGAAATGCACAGTTGGCACAATATAACTTCATCCTAGTTGTTGGTGAAAAAGAG
AAAACCAGCGGCACCGTCAATATCCGTACCAGAGACAATAAGGTGCACGGAGAGCGCACC
ATCTCGGAAACCATCGAGCGGCTCCAGCAGCTCAAGCACTCCCGCAGCAAACAGGCAGAA
GAAGAATTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 723 |
| Molecular Weight
| 83492.0 |
| Theoretical pI
| 6.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Threonyl-tRNA synthetase, cytoplasmic
MSEEQASSPSAKMGDEEKPVGAGEEKQKEGSKKKNKEGSGDGGRAELNPWPEYINTRLEM
YNKLKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNKAVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQAFERLEVKKETLLEMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIHKNSSTYWEGKSDMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNTLIEFI
RSEYRKRGFQEVVTPNIYNSRLWVTSGHWEHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRVADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSIFGFSFKLNLSTRPEKFLGDIEVWNQAEKQLENSLNDFGEKWELNPGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTFVSHDGDDKKKPVIIHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHNAKFMVDIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKTSGTVNIRTRDNKVHGERTISETIERLQQLKHSRSKQAE
EEF
|
| External Links |
|---|
| GenBank ID Protein
| AAI03083.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBV8 |
| UniProtKB/Swiss-Prot Entry Name
| SYTC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103082 |
| GeneCard ID
| TARS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
