| Identification |
|---|
| BMDB Protein ID
| BMDBP00396 |
| Secondary Accession Numbers
| None |
| Name
| Lipoyl synthase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| LIAS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. |
| Pathways
|
- Protein lipoylation via endogenous pathway
- Protein modification
- Protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| LIAS |
| Gene Sequence
|
>1119 bp
ATGTCTCTACGCTGCGGGGGCGCGGTCCGCACCGTGGGCCCCCGGGTATTTGGAAGATAT
GTATTCAGCCCTGTCAGAGAAGTAAGTTTCCTGCCAGATGAAAAAAAGGAATTTTTACAG
AGTGGACCAGACCTTCAAGAATTTATATCTGGTAATCTGGCTGACAAGAGTACCTGGGAT
GAATATAAAGGAAATTTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTA
AAAACAGAGATTCCTATGGGGAAAAATTATAATAAACTGAAAAACACTTTGCGGAATTTA
AATCTTCACACAGTGTGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGT
GGAGAATATGCTACCGCCACAGCCACAATCATGTTGATGGGTGACACATGTACAAGAGGT
TGTAGATTTTGTTCTGTTAAGACTGCAAGAAATCCACCTCCACTGGATGCCAATGAGCCC
TACAATACTGCAAAGGCAATTGCAGAGTGGGGTCTGGATTATGTTGTCCTGACATCTGTG
GATCGAGATGATATGCCTGATGGAGGAGCTGAGCACTTTGCAAAGACTGTATCTTACTTA
AAGGAAAGGAATCCAAAAATTCTTGTGGAATGTCTCACCCCTGATTTCCGAGGAGATCTT
AAAGCAATAGAAAAAGTTGCCCTGTCAGGATTAGATGTATATGCACATAATGTAGAAACA
GTTCCAGAATTACAGAGGAAAGTTCGTGATCCCCGGGCCAATTTTGACCAGTCTCTACGT
GTACTAAAACATGCCAAGGAGGTTCGACCTGATGTTATTTCTAAAACATCTATTATGTTG
GGTTTAGGTGAGAATGATGAGCAAGTATATGCCACGATGAAAGCACTTCGTGAGGCAGAT
GTGGACTGTTTGACTTTAGGACAATATATGCAGCCAACAAAGCGCCACCTTAAGGTTGAA
GAATACATTACTCCTGAAAAGTTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTT
CATTATACTGCAAGTGGCCCCCTGGTGCGTTCTTCATACAAAGCAGGTGAATTTTTCCTG
AAAAATCTAGTGGCTAAAAGAAAAACAAAAGCCCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 372 |
| Molecular Weight
| 42035.0 |
| Theoretical pI
| 8.86 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lipoyl synthase, mitochondrial
MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWD
EYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGG
GEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPYNTAKAIAEWGLDYVVLTSV
DRDDMPDGGAEHFAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVET
VPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREAD
VDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFL
KNLVAKRKTKAL
|
| External Links |
|---|
| GenBank ID Protein
| AAX31359.1 |
| UniProtKB/Swiss-Prot ID
| Q5BIP7 |
| UniProtKB/Swiss-Prot Entry Name
| LIAS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021177 |
| GeneCard ID
| LIAS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
