Showing Protein N-lysine methyltransferase KMT5A (BMDBP00398)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00398 |
| Secondary Accession Numbers | None |
| Name | N-lysine methyltransferase KMT5A |
| Synonyms | Not Available |
| Gene Name | KMT5A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in histone-lysine N-methyltransferase activity |
| Specific Function | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 17 |
| Locus | Not Available |
| SNPs | KMT5A |
| Gene Sequence |
>1059 bp ATGGCTAGAGGCAGGAAGATGTCCAAGCCCCGCGCGGTGGAGGCGGCGGCGGCGGCGGCG GCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCCC CGCACCAACGGGGAGAATGTATTTACCGGGCAATCAAAGATCTATACCTACATGAGCCCG AACAAATGCTCTGGAATGCGTTCCCCCCTTCAGGAAGAGAACTCAGTTGCACAATACGAA GTCAAATGCCAGGGGAAGCCATTAGCCGGAATCTACAGGAAACGCGACGAGAAAAGAAAC TCTGGGAATGCAATACGAAGCTCCATGAAGGCCGAGGAACAGAAGATCAAAGACGCCAGG AGAGGTCCCCTGGCACCTTTTCCAAACCAAAAATCTGAAGCTGCAGAACCTCCCAAAACC CCAACCTCGTCTTGTGATACTCCCAATGCAGCCGCTGCCAAGCAGGGCCTGAAAAAGCCT GTGAGGGGCAAACAGGCCCCCAGGAAAAAAGCTCAAGGAAAAACACAGCAGAATCGCAAG CTCACAGATTTCTACCCTGTGCGAAGGAGCTCAAGGAAGAGCAAGGCTGAGCTGCAGTCT GAAGAAAGGAAAAGAATAGATGAGTTGATTGAAAGCGGGAAGGAAGAAGGAATGAAGATC GACCTCATCGACGGCAAAGGCAGGGGCGTCATCGCCACCAAGCAGTTCTCCCGGGGTGAG TTTGTGGTGGAATACCACGGGGACCTCATCGAGATCACCGACGCCAAGAAGCGGGAGGCT CTGTACGCACAAGACCCCTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAAA ACCTACTGCGTGGATGCAACCCGAGAGACAAATCGCCTGGGAAGACTGATCAATCACAGT AAATGTGGGAACTGCCAAACCAAACTGCACGACATCGACGGCGTGCCTCACCTCATCCTC ATCGCCTCCCGTGACATCGAGGCCGGGGAGGAGCTTCTGTATGACTATGGGGACCGCAGC CGGGCTTCCATTGAAGCCTACCCCTGGCTGAAGCATTAA |
| Protein Properties | |
| Number of Residues | 352 |
| Molecular Weight | 39277.0 |
| Theoretical pI | 10.1 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Histone-lysine N-methyltransferase SETD8 MARGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPGRPRTNGENVFTGQSKIYTYMSP NKCSGMRSPLQEENSVAQYEVKCQGKPLAGIYRKRDEKRNSGNAIRSSMKAEEQKIKDAR RGPLAPFPNQKSEAAEPPKTPTSSCDTPNAAAAKQGLKKPVRGKQAPRKKAQGKTQQNRK LTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGE FVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHS KCGNCQTKLHDIDGVPHLILIASRDIEAGEELLYDYGDRSRASIEAYPWLKH |
| External Links | |
| GenBank ID Protein | AAI10190.1 |
| UniProtKB/Swiss-Prot ID | Q2YDJ8 |
| UniProtKB/Swiss-Prot Entry Name | KMT5A_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC110189 |
| GeneCard ID | KMT5A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |