Showing Protein Diphthine methyl ester synthase (BMDBP00399)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00399 |
| Secondary Accession Numbers | None |
| Name | Diphthine methyl ester synthase |
| Synonyms | Not Available |
| Gene Name | DPH5 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Translation, ribosomal structure and biogenesis |
| Specific Function | S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 3 |
| Locus | Not Available |
| SNPs | DPH5 |
| Gene Sequence |
>858 bp ATGCTTTACATGATTGGTTTGGGCCTGGGAGATGCCAAGGACATCACAGTCAAGGGCCTG GAAGTTGTCAGACGCTGCAGTCGAGTGTATCTGGAAACCTATACGTCAGTTCTGACTGTA GGGAAAGAAGTTCTGGAAGAGTTTTATGAGAGAAAATTGATTCTTGCTGATAGAGAAGAA GTGGAACAGGAGGCAGATAATATTTTAAAGGATGCTGATATCAGTGATGTTGCATTCCTT GTAGTTGGTGATCCATTTGGGGCTACAACACACAGTGATCTTATTCTGAGAGCAACAAAA CTGGGGATCCCTTATAGAGTTATTCACAATGCATCCATAATGAATGCTGTAGGCTGCTGC GGTTTGCAGTTGTATAAGTTTGGAGAGACAGTGTCTATTGTTTTCTGGACAGACACTTGG AGACCAGAAAGCTTCTTTGACAAAGTGAAGAAGAACAGACAAAATGGCATGCACACATTA TGCCTACTAGACATCAAAGTAAAGGAGCAGTCTTTGGAAAATCTAATCAAGGGAAGAAAG ATCTATGAACCTCCTCGGTATATGAGTGTCAACCAAGCAGCCCAGCAACTTCTGGAGATT GTTCAGAATCAGCGAATACGAGGAGAAGAACCAGCAGTCACCGAGGAGACACTCTGTGTT GGCTTAGCCAGGGTTGGCGCTGAGGACCAGAAAATTGCAGCAGGCACTTTGCAGCAGATG TCTACTGTGGACTTGGGAGGACCATTGCATTCCTTGATTATCACTGGAGGCAGCTTGCAT CCACTGGAGATGGAGATGCTAAGTCTGTTTACCATACCAGAAAATAGCTCAGAAGCCCAA AGCATTGGTGGACTCTGA |
| Protein Properties | |
| Number of Residues | 285 |
| Molecular Weight | 31662.0 |
| Theoretical pI | 4.86 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Diphthine synthase MLYMIGLGLGDAKDITVKGLEVVRRCSRVYLETYTSVLTVGKEVLEEFYERKLILADREE VEQEADNILKDADISDVAFLVVGDPFGATTHSDLILRATKLGIPYRVIHNASIMNAVGCC GLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRK IYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQM STVDLGGPLHSLIITGGSLHPLEMEMLSLFTIPENSSEAQSIGGL |
| External Links | |
| GenBank ID Protein | AAX09055.1 |
| UniProtKB/Swiss-Prot ID | Q5E982 |
| UniProtKB/Swiss-Prot Entry Name | DPH5_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT021038 |
| GeneCard ID | DPH5 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |