Showing Protein Putative histone-lysine N-methyltransferase PRDM6 (BMDBP00400)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00400 |
| Secondary Accession Numbers | None |
| Name | Putative histone-lysine N-methyltransferase PRDM6 |
| Synonyms | Not Available |
| Gene Name | PRDM6 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in histone-lysine N-methyltransferase activity |
| Specific Function | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | PRDM6 |
| Gene Sequence |
>1773 bp ATGCTGAAGCCCGGAGACCCCGGCGGCTCGGCCTTCCTCAAAGTGGACCCAGCTTATCTG CAACACTGGCAGCAACTCTTCCCGCACGGGGGCGGAGGCCCGCTCAAGGGCGGCGGTGCC GCGGGTCCCCTGGGCGCACCACAGCCTCTCCAGCCACCGCCACCACCGGAGCGCGCTGAG CCCCAGCCAGACAGCCTGCGGCCGCGGCCGGCCTCGCTCTCCTCCGCCTCGTCCACTCCG GCTTCCTCCTCCACCTCGGCCTCCTCTGCCTCCTCCTGCGCTGCTGCTGCCGCCGCTGCC GCCGCCGCCGCGCTGGCCGGTCTCTCGGCCCTGCCGGTGGCGCAGCTGCCGGTGTTCGCG CCTCTGGCCACCGTCGCCGCGGAGCCTCTGCCCCCCAAGGACCTGTGCCTCGGCGCCACC TCGGGCCCGGGGCCCTCCAAGTGCGGAGGCAGTGGCGGGGACGGCCGGGGTGTCCCGCGC TTCCGCTGCAGCGCGGAGGAGCTGGACTATTACCTGTACGGCCAGCAGCGCATGGAGATC ATCCCGCTCAACCAGCACACCAGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAAC CGCAACGGCGAGTGCCCCATGCACGGGCCGCTGCACTCGCTGCGCCGGCTCGTGGGCACC AGCAGCGCCGCGGCCGCCGCGCCCCCGCCGGAGCTACCCGAGTGGCTGCGGGACCTGCCC AGGGAGGTGTGCCTGTGCACCAGCACCGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCG CAGAGGATCCAGCAGGGCACCTGGATCGGGCCCTTCCAGGGCGTGCTCCTGCCCCCGGAA AAGGTGCAGGCCGGAGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAAGAT GGGACACTACAGCACTTTATTGATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTAT ATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTACAGGTCGAAT ATATTCTACCGAGCCTGTATAGATATTCCCAGGGGTACCGAGCTTCTCGTGTGGTACAAT GACAGCTATACGTCTTTCTTTGGGATCCCTTTACAATGCATTGCCCAGGATGAAAACTTA AATGTCCCCTCGACAGTCATGGAAGCCATGTGCAGACAGGACGCCCTGCAGCCCTTCAAC AAGAGCAGCAAACTCTCCCAGGCTCCCCAGCAGCGCTCTGTTGTCTTCCCCCAGACTCCG TGCGGCAGGAACTTCTCCCTCCTGGATAAGTCAGGGCCCCTGGAATCTGGATTTAATCAA ATCAGCGTGAAGAACCAGCGCGTCCTGGCGAGCCCCACCTCCACCAGCCAGCTCCACTCG GAGTTCAGTGACTGGCACCTCTGGAAATGTGGGCAGTGCTTTAAGACTTTTACGCAGCGG ATCCTGCTACAGATGCACGTGTGCACACAGAACCCTGACAGACCTTACCAATGCGGCCAC TGCTCCCAGTCCTTTTCCCAGCCTTCAGAACTGAGGAACCACGTGGTCACTCACTCCAGT GACCGGCCTTTCAAATGCGGCTACTGTGGTCGTGCCTTTGCTGGGGCCACCACTCTCAAC AACCACATCCGAACCCACACTGGAGAAAAGCCCTTCAAGTGTGAGAGGTGTGAGAGGAGC TTCACGCAGGCCACCCAGCTGAGCCGACACCAGCGGATGCCCAATGAGTGCAAGCCAATA ACCGAGAGCCCAGAATCAATCGAAGTGGATTAA |
| Protein Properties | |
| Number of Residues | 590 |
| Molecular Weight | 63989.0 |
| Theoretical pI | 7.73 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Putative histone-lysine N-methyltransferase PRDM6 MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGGGPLKGGGAAGPLGAPQPLQPPPPPERAE PQPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAAAAALAGLSALPVAQLPVFA PLATVAAEPLPPKDLCLGATSGPGPSKCGGSGGDGRGVPRFRCSAEELDYYLYGQQRMEI IPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLP REVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQD GTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN DSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLSQAPQQRSVVFPQTP CGRNFSLLDKSGPLESGFNQISVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQR ILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLN NHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD |
| External Links | |
| GenBank ID Protein | AAI49388.1 |
| UniProtKB/Swiss-Prot ID | A6QPM3 |
| UniProtKB/Swiss-Prot Entry Name | PRDM6_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC149387 |
| GeneCard ID | PRDM6 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |