| Identification |
|---|
| BMDB Protein ID
| BMDBP00400 |
| Secondary Accession Numbers
| None |
| Name
| Putative histone-lysine N-methyltransferase PRDM6 |
| Synonyms
|
Not Available
|
| Gene Name
| PRDM6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histone-lysine N-methyltransferase activity |
| Specific Function
| Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| PRDM6 |
| Gene Sequence
|
>1773 bp
ATGCTGAAGCCCGGAGACCCCGGCGGCTCGGCCTTCCTCAAAGTGGACCCAGCTTATCTG
CAACACTGGCAGCAACTCTTCCCGCACGGGGGCGGAGGCCCGCTCAAGGGCGGCGGTGCC
GCGGGTCCCCTGGGCGCACCACAGCCTCTCCAGCCACCGCCACCACCGGAGCGCGCTGAG
CCCCAGCCAGACAGCCTGCGGCCGCGGCCGGCCTCGCTCTCCTCCGCCTCGTCCACTCCG
GCTTCCTCCTCCACCTCGGCCTCCTCTGCCTCCTCCTGCGCTGCTGCTGCCGCCGCTGCC
GCCGCCGCCGCGCTGGCCGGTCTCTCGGCCCTGCCGGTGGCGCAGCTGCCGGTGTTCGCG
CCTCTGGCCACCGTCGCCGCGGAGCCTCTGCCCCCCAAGGACCTGTGCCTCGGCGCCACC
TCGGGCCCGGGGCCCTCCAAGTGCGGAGGCAGTGGCGGGGACGGCCGGGGTGTCCCGCGC
TTCCGCTGCAGCGCGGAGGAGCTGGACTATTACCTGTACGGCCAGCAGCGCATGGAGATC
ATCCCGCTCAACCAGCACACCAGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAAC
CGCAACGGCGAGTGCCCCATGCACGGGCCGCTGCACTCGCTGCGCCGGCTCGTGGGCACC
AGCAGCGCCGCGGCCGCCGCGCCCCCGCCGGAGCTACCCGAGTGGCTGCGGGACCTGCCC
AGGGAGGTGTGCCTGTGCACCAGCACCGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCG
CAGAGGATCCAGCAGGGCACCTGGATCGGGCCCTTCCAGGGCGTGCTCCTGCCCCCGGAA
AAGGTGCAGGCCGGAGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAAGAT
GGGACACTACAGCACTTTATTGATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTAT
ATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTACAGGTCGAAT
ATATTCTACCGAGCCTGTATAGATATTCCCAGGGGTACCGAGCTTCTCGTGTGGTACAAT
GACAGCTATACGTCTTTCTTTGGGATCCCTTTACAATGCATTGCCCAGGATGAAAACTTA
AATGTCCCCTCGACAGTCATGGAAGCCATGTGCAGACAGGACGCCCTGCAGCCCTTCAAC
AAGAGCAGCAAACTCTCCCAGGCTCCCCAGCAGCGCTCTGTTGTCTTCCCCCAGACTCCG
TGCGGCAGGAACTTCTCCCTCCTGGATAAGTCAGGGCCCCTGGAATCTGGATTTAATCAA
ATCAGCGTGAAGAACCAGCGCGTCCTGGCGAGCCCCACCTCCACCAGCCAGCTCCACTCG
GAGTTCAGTGACTGGCACCTCTGGAAATGTGGGCAGTGCTTTAAGACTTTTACGCAGCGG
ATCCTGCTACAGATGCACGTGTGCACACAGAACCCTGACAGACCTTACCAATGCGGCCAC
TGCTCCCAGTCCTTTTCCCAGCCTTCAGAACTGAGGAACCACGTGGTCACTCACTCCAGT
GACCGGCCTTTCAAATGCGGCTACTGTGGTCGTGCCTTTGCTGGGGCCACCACTCTCAAC
AACCACATCCGAACCCACACTGGAGAAAAGCCCTTCAAGTGTGAGAGGTGTGAGAGGAGC
TTCACGCAGGCCACCCAGCTGAGCCGACACCAGCGGATGCCCAATGAGTGCAAGCCAATA
ACCGAGAGCCCAGAATCAATCGAAGTGGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 590 |
| Molecular Weight
| 63989.0 |
| Theoretical pI
| 7.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Putative histone-lysine N-methyltransferase PRDM6
MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGGGPLKGGGAAGPLGAPQPLQPPPPPERAE
PQPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAAAAALAGLSALPVAQLPVFA
PLATVAAEPLPPKDLCLGATSGPGPSKCGGSGGDGRGVPRFRCSAEELDYYLYGQQRMEI
IPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLP
REVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQD
GTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYN
DSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLSQAPQQRSVVFPQTP
CGRNFSLLDKSGPLESGFNQISVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQR
ILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLN
NHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI49388.1 |
| UniProtKB/Swiss-Prot ID
| A6QPM3 |
| UniProtKB/Swiss-Prot Entry Name
| PRDM6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149387 |
| GeneCard ID
| PRDM6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
