Showing Protein S-adenosylmethionine synthase isoform type-1 (BMDBP00403)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 11 metabolites
Identification
BMDB Protein ID BMDBP00403
Secondary Accession Numbers None
Name S-adenosylmethionine synthase isoform type-1
Synonyms Not Available
Gene Name MAT1A
Protein Type Enzyme
Biological Properties
General Function Coenzyme transport and metabolism
Specific Function Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Pathways
  • Amino-acid biosynthesis
  • Betaine Metabolism
  • Methionine Metabolism
  • S-adenosyl-L-methionine biosynthesis
  • S-adenosyl-L-methionine from L-methionine: step 1/1
  • Selenoamino Acid Metabolism
  • Spermidine and Spermine Biosynthesis
Reactions
Selenomethionine + Adenosine triphosphate + Water → Se-Adenosylselenomethionine + Hydrogen phosphate + Pyrophosphate details
Adenosine triphosphate + L-Methionine + Water → S-Adenosylmethionine + Hydrogen phosphate + Pyrophosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 28
Locus Not Available
SNPs MAT1A
Gene Sequence 
>1191 bp
ATGAATGGACCAGTGGATGGCTTGTGTGATCATTCTCTAAGTGAGGAAGGAGCATTCATG
TTCACATCGGAATCTGTAGGAGAGGGGCACCCGGATAAGATCTGTGACCAGATCAGTGAT
GCAGTGCTGGATGCCCATCTCAAGCAGGACCCCAATGCCAAGGTGGCCTGTGAGACGGTG
TGTAAGACGGGCATGGTGCTTCTGTGCGGGGAGATCACCTCCATGGCCATGGTGGATTAC
CAGCGTGTGGTGCGGGAGACCATCCAGCACATCGGCTACGACGACTCCGCCAAGGGCTTT
GACTTTAAGACCTGCAACGTGCTGGTGGCTTTGGAGCAGCAGTCCCCGGATATCGCCCAG
TGTGTCCACCTGGACAGAAATGAAGAGGATGTCGGTGCCGGAGATCAGGGGCTGATGTTT
GGCTATGCCACGGATGAGACGGAAGAGTGCATGCCCCTCACCATCATGCTGGCGCACAGA
CTCAACGCCCGCATGGCAGAGCTGCGACGCTCAGGGCAGCTCCCCTGGCTGCAACCTGAC
TCCAAGACACAGGTGACAGTGCAGTACACGCAGGACAACGGTGCGGTCATCCCTATGCGC
GTCCATACCGTCGTCATCTCCGTGCAGCACAACGAAGACATAACGCTGGAGGACATGCGC
AGAGCCCTGAAGGAGCAGGTGATCAGGGCTGTTGTGCCAGCACGGTACCTGGACGAGGAC
ACCATCTACCACCTGCAGCCCAGTGGGCGCTTTGTCATCGGAGGCCCCCAGGGGGATGCC
GGTGTCACTGGCCGAAAGATCATCGTGGACACCTATGGCGGCTGGGGGGCACACGGCGGA
GGCGCCTTCTCTGGGAAGGACTACACCAAGGTGGACCGCTCGGCAGCGTACGCTGCCCGC
TGGGTGGCCAAGTCCCTGGTGAAAGCAGGGCTCTGCCGGAGGGTGCTTGTGCAGGTGTCC
TATGCCATTGGTGTGGCTGAGCCACTGTCTATTTCCATCTTTACCTATGGAACCTCCCAG
AAGACAGAGAGAGAGCTGCTGGATGTGGTCAATAAGAACTTTGACCTTCGGCCTGGTGTT
ATCGTCAGGGACTTGGACTTGAAGAAGCCCATCTACCAGAAGACAGCATGCTACGGCCAC
TTCGGGAGGAGCGAGTTCCCTTGGGAAGTTCCCAAAAAGCTTGTGTTTTAG
Protein Properties
Number of Residues 396
Molecular Weight 43761.0
Theoretical pI 5.61
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>S-adenosylmethionine synthetase isoform type-1
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMVDYQRVVRETIQHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIMLAHRLNARMAELRRSGQLPWLQPD
SKTQVTVQYTQDNGAVIPMRVHTVVISVQHNEDITLEDMRRALKEQVIRAVVPARYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVNKNFDLRPGV
IVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
GenBank ID Protein AAI05411.1
UniProtKB/Swiss-Prot ID Q2KJC6
UniProtKB/Swiss-Prot Entry Name METK1_BOVIN
PDB IDs
GenBank Gene ID BC105410
GeneCard ID MAT1A
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available