Showing Protein Protein arginine N-methyltransferase 7 (BMDBP00406)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00406 |
| Secondary Accession Numbers | None |
| Name | Protein arginine N-methyltransferase 7 |
| Synonyms | Not Available |
| Gene Name | PRMT7 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in [myelin basic protein]-arginine N-methyltra |
| Specific Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | PRMT7 |
| Gene Sequence |
>2088 bp ATGAAAGTCTTCTGTGGGCGGGCCAATCCGACCACAGGATCTGTGGAGTGGCTGGAGGAG GATGAGCATTATGACTACCACCAGGAGATTGCAAGGTCATCCTATGCTGATATGTTGCAT GACAAAGATAGGAATATGAAATACTACCAGGGCATCCGGGCTGCTGTGAGCCGGGTGAAG GACAGAGGACAGAAGGCCTTGGTTCTTGACATTGGCACTGGCACAGGACTCTTGTCAATG ATGGCGGTCACGGCTGGTGCCGACTTCTGCTATGCCATTGAGGTTTTCAAGCCTATGGCT GACGCTGCTGTGAAGATTGTGGAGAAAAACGGCTTCAGTGATAAGATTAAGGTTATCAAT AAGCATTCCACTGAGGTGACTGTAGGACCAGATGGTGACATGCCATGCCGTGCCAACATC CTGATCACGGAGCTGTTTGACACGGAACTGATTGGGGAGGGAGCCCTGCCCTCCTATGAG CATGCACACAGGCATCTTGTGCAGGCAAATTGTGAAGCAGTGCCTCACAGAGCAACCGTC TATGCACAGCTGGTAGAGTCCAGGAGGATGTGGTCATGGAATAAGCTGTTTCCCATCCGT GTTCAGACCAGCCGTGGAGAGCGGGTCATCATCCCCCCCTTGGAACTGGAGAGGTGCCCT GGCGCGCCCTCTGTCTGCGACATTCAGCTAAACCAGGTGTCGCCCGCTGACTTCACCATC CTCAGCGACGTGCTGCCTATGTTCAGTGTGGACTTCAGCAAGCAAGTCAGTAGCTCAGCA GCCTGCCATAGCAGGCAGTTTGAACCGCTAGTGTCTGGCCGAGCTCAGGTGGTTCTCTCC TGGTGGGACATTGAAATGGACCCTGAGGGGAAGATCAAGTGCACCATGGCCCCCTCCTGG GCACACTCAGACCCAGAGGAGCTCCAGTGGCGGGACCACTGGATGCAGTGTGTGTACTTC CTACCACAGGAGGAGCCTGTTGTCCAGGGCTTAGCCCTCTGCCTGGTAGCCTACCACGAC GACTACTGTGTGTGGTATAGCCTTCAGAAGACCAGTCCTGAAAAGAATGGGAGAGTCCAC CCAGTGCGCCCCGTGTGTGACTGCCAGGCTCACCTGCTCTGGAACCGACCTCGGTTTGGA GAGATCAATGATCGGAACAGAACTGATCAATACATCCAGGCCCTGAGGACAGTGCTGAAG CCGGACAGTGTCTGCCTGTGCGTCAGTGATGGCAGTCTGCTGTCCATGCTGGCCTATCAC CTTGGGGTGGAGCAGGTATTTACAATAGAGAACTCAGCAGTTTCTCATAGACTGATGAAA AAAATCTTCAAGGCCAACCACTTGGAAGACAAAATTAATATAATAGAGAAACGGCCTGAA TTATTAACACCTGCAGACTTGGAGGGTAAAAAGGTTTCTCTCCTGCTGGGTGAGCCGTTC TTCACCACCAGCCTGCTTCCGTGGCACAACTTGTACTTCTGGTATGTGCGGACTGCTGTG GACCAACACCTGGGGCCTGGCGCTGTGGTGATGCCCCAGGCTGCCTCACTGCACGTGGTG GTCGTGGAGTTCAGGGACCTGTGGCGGATCCGGAGCCCCTGTGGTGACTGTGAAGGCTTC GATGTGCACATCATGGATGACATGATTAAGCGTGCCCTGGACTTCAGGGAGAGCAAGGAG GCCGAGCCCCACCCACTGTGGGAGTACCCGTGCAGCAGCCTCTCCGAGCCCCAGCAGATC CTGACCTTTGATTTTCGGCAGCCAGTCCCCCTGCAGCCTATCCATGCTGAGGGCACCATC GAGCTGAGAAGGTGTGGGAGGAGCCACGGAGCTGTCCTGTGGATGGAATACCACCTGACT GCGGACAGCACAGTCAGCACCGGCCTCCTGAAGTCTGCAGAGGACGAGGGGGACTGTTGC TGGAACCCCCATTGTAAGCAGGCCGTGTACTTCTTCAACACCACACTCGACCCCAGAGCA CCGCCGGGCAGCTCGCAGACCGTCACCTACACTGTGGAGTTCCACCCCCACACTGGAGAC ATCACCATGGATTTCACGCTCTCAGATGCGCTGGACAGTGGGTGCTAA |
| Protein Properties | |
| Number of Residues | 695 |
| Molecular Weight | 78654.0 |
| Theoretical pI | 5.78 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Protein arginine N-methyltransferase 7 MKVFCGRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNMKYYQGIRAAVSRVK DRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVIN KHSTEVTVGPDGDMPCRANILITELFDTELIGEGALPSYEHAHRHLVQANCEAVPHRATV YAQLVESRRMWSWNKLFPIRVQTSRGERVIIPPLELERCPGAPSVCDIQLNQVSPADFTI LSDVLPMFSVDFSKQVSSSAACHSRQFEPLVSGRAQVVLSWWDIEMDPEGKIKCTMAPSW AHSDPEELQWRDHWMQCVYFLPQEEPVVQGLALCLVAYHDDYCVWYSLQKTSPEKNGRVH PVRPVCDCQAHLLWNRPRFGEINDRNRTDQYIQALRTVLKPDSVCLCVSDGSLLSMLAYH LGVEQVFTIENSAVSHRLMKKIFKANHLEDKINIIEKRPELLTPADLEGKKVSLLLGEPF FTTSLLPWHNLYFWYVRTAVDQHLGPGAVVMPQAASLHVVVVEFRDLWRIRSPCGDCEGF DVHIMDDMIKRALDFRESKEAEPHPLWEYPCSSLSEPQQILTFDFRQPVPLQPIHAEGTI ELRRCGRSHGAVLWMEYHLTADSTVSTGLLKSAEDEGDCCWNPHCKQAVYFFNTTLDPRA PPGSSQTVTYTVEFHPHTGDITMDFTLSDALDSGC |
| External Links | |
| GenBank ID Protein | AAI50010.1 |
| UniProtKB/Swiss-Prot ID | A6QQV6 |
| UniProtKB/Swiss-Prot Entry Name | ANM7_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC150009 |
| GeneCard ID | PRMT7 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |