| Identification |
|---|
| BMDB Protein ID
| BMDBP00406 |
| Secondary Accession Numbers
| None |
| Name
| Protein arginine N-methyltransferase 7 |
| Synonyms
|
Not Available
|
| Gene Name
| PRMT7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in [myelin basic protein]-arginine N-methyltra |
| Specific Function
| Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| PRMT7 |
| Gene Sequence
|
>2088 bp
ATGAAAGTCTTCTGTGGGCGGGCCAATCCGACCACAGGATCTGTGGAGTGGCTGGAGGAG
GATGAGCATTATGACTACCACCAGGAGATTGCAAGGTCATCCTATGCTGATATGTTGCAT
GACAAAGATAGGAATATGAAATACTACCAGGGCATCCGGGCTGCTGTGAGCCGGGTGAAG
GACAGAGGACAGAAGGCCTTGGTTCTTGACATTGGCACTGGCACAGGACTCTTGTCAATG
ATGGCGGTCACGGCTGGTGCCGACTTCTGCTATGCCATTGAGGTTTTCAAGCCTATGGCT
GACGCTGCTGTGAAGATTGTGGAGAAAAACGGCTTCAGTGATAAGATTAAGGTTATCAAT
AAGCATTCCACTGAGGTGACTGTAGGACCAGATGGTGACATGCCATGCCGTGCCAACATC
CTGATCACGGAGCTGTTTGACACGGAACTGATTGGGGAGGGAGCCCTGCCCTCCTATGAG
CATGCACACAGGCATCTTGTGCAGGCAAATTGTGAAGCAGTGCCTCACAGAGCAACCGTC
TATGCACAGCTGGTAGAGTCCAGGAGGATGTGGTCATGGAATAAGCTGTTTCCCATCCGT
GTTCAGACCAGCCGTGGAGAGCGGGTCATCATCCCCCCCTTGGAACTGGAGAGGTGCCCT
GGCGCGCCCTCTGTCTGCGACATTCAGCTAAACCAGGTGTCGCCCGCTGACTTCACCATC
CTCAGCGACGTGCTGCCTATGTTCAGTGTGGACTTCAGCAAGCAAGTCAGTAGCTCAGCA
GCCTGCCATAGCAGGCAGTTTGAACCGCTAGTGTCTGGCCGAGCTCAGGTGGTTCTCTCC
TGGTGGGACATTGAAATGGACCCTGAGGGGAAGATCAAGTGCACCATGGCCCCCTCCTGG
GCACACTCAGACCCAGAGGAGCTCCAGTGGCGGGACCACTGGATGCAGTGTGTGTACTTC
CTACCACAGGAGGAGCCTGTTGTCCAGGGCTTAGCCCTCTGCCTGGTAGCCTACCACGAC
GACTACTGTGTGTGGTATAGCCTTCAGAAGACCAGTCCTGAAAAGAATGGGAGAGTCCAC
CCAGTGCGCCCCGTGTGTGACTGCCAGGCTCACCTGCTCTGGAACCGACCTCGGTTTGGA
GAGATCAATGATCGGAACAGAACTGATCAATACATCCAGGCCCTGAGGACAGTGCTGAAG
CCGGACAGTGTCTGCCTGTGCGTCAGTGATGGCAGTCTGCTGTCCATGCTGGCCTATCAC
CTTGGGGTGGAGCAGGTATTTACAATAGAGAACTCAGCAGTTTCTCATAGACTGATGAAA
AAAATCTTCAAGGCCAACCACTTGGAAGACAAAATTAATATAATAGAGAAACGGCCTGAA
TTATTAACACCTGCAGACTTGGAGGGTAAAAAGGTTTCTCTCCTGCTGGGTGAGCCGTTC
TTCACCACCAGCCTGCTTCCGTGGCACAACTTGTACTTCTGGTATGTGCGGACTGCTGTG
GACCAACACCTGGGGCCTGGCGCTGTGGTGATGCCCCAGGCTGCCTCACTGCACGTGGTG
GTCGTGGAGTTCAGGGACCTGTGGCGGATCCGGAGCCCCTGTGGTGACTGTGAAGGCTTC
GATGTGCACATCATGGATGACATGATTAAGCGTGCCCTGGACTTCAGGGAGAGCAAGGAG
GCCGAGCCCCACCCACTGTGGGAGTACCCGTGCAGCAGCCTCTCCGAGCCCCAGCAGATC
CTGACCTTTGATTTTCGGCAGCCAGTCCCCCTGCAGCCTATCCATGCTGAGGGCACCATC
GAGCTGAGAAGGTGTGGGAGGAGCCACGGAGCTGTCCTGTGGATGGAATACCACCTGACT
GCGGACAGCACAGTCAGCACCGGCCTCCTGAAGTCTGCAGAGGACGAGGGGGACTGTTGC
TGGAACCCCCATTGTAAGCAGGCCGTGTACTTCTTCAACACCACACTCGACCCCAGAGCA
CCGCCGGGCAGCTCGCAGACCGTCACCTACACTGTGGAGTTCCACCCCCACACTGGAGAC
ATCACCATGGATTTCACGCTCTCAGATGCGCTGGACAGTGGGTGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 695 |
| Molecular Weight
| 78654.0 |
| Theoretical pI
| 5.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein arginine N-methyltransferase 7
MKVFCGRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNMKYYQGIRAAVSRVK
DRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVIN
KHSTEVTVGPDGDMPCRANILITELFDTELIGEGALPSYEHAHRHLVQANCEAVPHRATV
YAQLVESRRMWSWNKLFPIRVQTSRGERVIIPPLELERCPGAPSVCDIQLNQVSPADFTI
LSDVLPMFSVDFSKQVSSSAACHSRQFEPLVSGRAQVVLSWWDIEMDPEGKIKCTMAPSW
AHSDPEELQWRDHWMQCVYFLPQEEPVVQGLALCLVAYHDDYCVWYSLQKTSPEKNGRVH
PVRPVCDCQAHLLWNRPRFGEINDRNRTDQYIQALRTVLKPDSVCLCVSDGSLLSMLAYH
LGVEQVFTIENSAVSHRLMKKIFKANHLEDKINIIEKRPELLTPADLEGKKVSLLLGEPF
FTTSLLPWHNLYFWYVRTAVDQHLGPGAVVMPQAASLHVVVVEFRDLWRIRSPCGDCEGF
DVHIMDDMIKRALDFRESKEAEPHPLWEYPCSSLSEPQQILTFDFRQPVPLQPIHAEGTI
ELRRCGRSHGAVLWMEYHLTADSTVSTGLLKSAEDEGDCCWNPHCKQAVYFFNTTLDPRA
PPGSSQTVTYTVEFHPHTGDITMDFTLSDALDSGC
|
| External Links |
|---|
| GenBank ID Protein
| AAI50010.1 |
| UniProtKB/Swiss-Prot ID
| A6QQV6 |
| UniProtKB/Swiss-Prot Entry Name
| ANM7_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC150009 |
| GeneCard ID
| PRMT7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
