| Identification |
|---|
| BMDB Protein ID
| BMDBP00407 |
| Secondary Accession Numbers
| |
| Name
| DNA (cytosine-5)-methyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| DNMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth. |
| Pathways
|
Not Available
|
| Reactions
|
| S-Adenosylmethionine + Glycine → S-Adenosylhomocysteine + Sarcosine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q15 |
| SNPs
| DNMT1 |
| Gene Sequence
|
>4836 bp
ATGCCTGCCCGAACCGCCCCGGCGCGGGTGCCTGCGCTGGCCTCCCGGGCCTTCTCACTG
CCTGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGATAGTTTGACAGAAAAGGAA
TGTGTGAAGGAGAAACTGAATCTCTTGCACGAATTTCTGCGGACAGAAATAAAGAATCAG
TTATGTGATTTGGAAACCAAATTGCATAAAGAAGAATTATCTGAGGAGGGCTACCTGGCT
AAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGAGCTCATGCTTTCAGT
CGGGAAGCGAATGGATGTCTAGAGAACGGGAGCCAGACAAGTGGTGAGGATTGCAGAGTG
GTAATGGCAGAGAAAGGCAAGCCCCCCAAACCTGTCTCCAGACTTTACACGCCCAGGAGA
AGCAAGTCTGATGGAGAAACAAAGTCTGAAGTCTCTTCTAGCCCCAGGATTACAAGGAAG
ACTACCAGGCAGACCACCATCACATCTCATTTCCCACGGGGCCCTGCCAAACGAAAACCT
GAGGAAGAACCTGAAAAAGTGAAGTCAGACGATTCTGTTGATGAAGAAAAAGACCAGGAG
GAAAAGAGACGTCGAGTTACATCCAGAGAACGAGTTGCTGGGCTGCTCCCTGCAGAAGAA
CCAGGAAGAGTAAGACCAGGAACACACATGGAAGAAGAAGGAAGAGATGATAAAGAAGAA
AAGAGACTCAGAAGTCAAACCAAAGAACCGACACCTAAACACAAAGCTAAGGAGGAGCCA
GACAGAGATGTGAGGCCTGGAGGAGCTCAGGCTGAAATGAATGAAGGAGAAGACAAAGAT
GAAAAGAGGCACAGAAGTCAACCCAAAGATCTAGCTAGCAAACGGAGACCAGAAGAAAAA
GAACCTGAAAGAGTAAAGCCACAAGTTTCTGATGAGAAAGATGAAGATGAAAAGGAGGAG
AAGAGACGCAGAACTACATACAGAGAACTAACCGAGAAGAAAATGACTCGAACCAAAATA
GCCGTAGTGTCCAAGACCAATCCTCCGAAGTGCACCGAGTGCTTGCAGTACCTGGACGAC
CCTGAGCTGAGATACGAGCAGCACCCCCCCGATGCGGTGGAAGAGATACAGATACTGACC
AACGAGAGGTTGTCCATCTTTGATGCCAACGAATCTGGCTTTGAGAGTTACGAGGATTTG
CCTCAGCACAAACTAACCTGCTTCAGCGTGTACTGTAAACGCGGTCACCTTTGCCCGATC
GACACCGGCCTCATTGAGAAGGATGTCGAGCTCCTCTTTTCTGGTTCAGCAAAGCCGATA
TATGAGGATGACCCATCTCCCGAAGGTGGTATTAATGGCAAAAATTTTGGCCCCATAAAC
GAATGGTGGATTGCTGGTTTTGATGGAGGTGAAAAGGCTCTTCTTGGCTTTAGCACCTCA
TTTGCCGAGTATATCTTGATGGATCCCAGCCCAGAGTACGCACCACTATTCAGCGTGATG
CAGGAGAAGATCTATATAAGTAAGATAGTGGTTGAGTTCCTGCAGAGCAACCCTGACTCC
ACCTACGAAGACCTGATCAATAAGATTGAGACCACCGTTCCTCCTTGTATGCTCAACTTG
AATCGATTCACAGAGGATTCTCTCCTGCGGCATGCCCAGTTCGTGGTGGAGCAAGTAGAG
AGTTATGATCGGGCTGGGGACAGTGACGAGCAGCCCATCTTCCTGAGCCCCTGCATGAGA
GACCTCATCAAGCTGGCCGGGGTCACCCTGGGAAAAAGGCGAGCCGAGAGGCGGCAGACC
ATCCGGCAACCCGCCAAAGAGAAGGACAAGGGCCCCACCAAGGCCACCACCACCAAGCTG
GTCTACCAGATCTTTGACACTTTCTTTGCGGAGCAAATTGAAAAAGATGACAAGGAAGAC
AAGGAGAATGCCTTCAAGCGCCGGCGCTGTGGCGTCTGTGAGATTTGTCAACAGCCCGAG
TGTGGAAAGTGTAAGGCCTGTAAGGATATGGTTAAATTTGGTGGTAGCGGACGGAGCAAG
CAGGCTTGCCAAAAGAGGAGGTGTCCCAACATGGCCATGAAGGAGGCAGACGATGACGAG
GAAGTGGATGACAATATTCCAGAGATGCCATCACCCAAAAAGATGCATCAGGGGAAGAAA
AAGAAGCAGAATAAGAATCGGATCTCTTGGGTTGGCGATGCCGTCAAGACTGACGGGAAG
AAGAGTTACTACAAGAAGGTATGCATCGACTCGGAAACCCTGGAAGTGGGGGACTGTGTT
TCTGTAATTCCAGACGACTCTTCAAAACCACTGTATCTAGCAAGGGTCACGGCGCTGTGG
GAGGACAGCAGCAATGGGCAGATGTTCCATGCCCACTGGTTCTGTGCTGGGACGGACACG
GTCCTCGGGGCCACATCGGACCCCCTGGAGCTGTTCCTGGTTGACGAGTGTGAGGACATG
CAGCTCTCGTACATCCACAGCAAGGTGCAGGTCATTTATAAGGCGCCCTCAGAGAACTGG
GCCATGGAGGGAGGCGTGGACCCCGAGGCCCTGATGTCAGAGGACGACGGGAAGACCTAC
TTCTACCAGCTGTGGTACGACCAAGACTACGCGAGATTTGAGTCCCCTCCGAAAACTCAG
CCGACGGAGGACAACAAGTACAAGTTCTGCGCAAGCTGTGCACGTCTGGCCGAAATGAGG
CAGAAGGAAATCCCCAGGGTCGTGGAGCAGCTCCAGGACCTGGAAGGCCGCGTCCTCTAC
AGCCTCGCCACCAAGAACGGCGTCCAGTACCGGGTGGGCGATGGCGTGTACCTCCCTCCC
GAGGCCTTCACCTTCAACATCAAGCTGTCCAGTCCTGTGAAACGCCCCCGGAAGGAGCCT
GTGGACGAAGCTCTGTATCCAGAACACTACCGGAAGTACTCTGACTACATCAAGGGCAGC
AACCTGGATGCCCCTGAGCCCTACCGTATTGGCCGCATAAAGGAGATCTTCTGCAGCAAG
AAGAGCAACGGCCGGCCCAATGAGACAGACATCAAGATCAGGGTCAACAAGTTCTACAGG
CCGGAGAACACACACAAGTCTACCCCAGCCAGTTACCACGCAGACATCAACCTGCTTTAC
TGGAGCGATGAGGAGGCCGTGGTGGACTTCAAGGCCGTGCAGGGCCGCTGCACCGTGGAG
TACGGAGAGGACCTGCCTCAGTGCCTCCAGGACTTCTCCGCTGGTGGCCCCGATCGCTTC
TATTTTCTCGAGGCCTATAACGCCAAGAGCAAAAGCTTTGAAGATCCTCCGAACCACGCC
CGGAGCACCGGAAATAAAGGGAAAGGGAAGGGGAAAGGAAAAAACAGGACGAAATCTCAG
ACGTGTGAGCCGAGTGAACTGGAGACAGAAATCAAACTGCCGAAGCTGCGGACCCTGGAC
GTGTTTTCCGGCTGTGGGGGATTGTCGGAAGGCTTCCACCAAGCAGGCATCTCGGAAACA
CTTTGGGCCATCGAGATGTGGGACCCTGCGGCCCAGGCGTTCCGGTTCAACAACCCTGGG
TCCACGGTGTTCACAAAGGACTGCAACGTCCTGGTGAAGCTGGTCATGGCCGGGGAGGTG
ACCAACTCCCGCGGCCAGAAGCTGCTTCAAAAGGGAGATGTGGAGATGTTGTGCGGCGGG
CCGCCCTGCCAGGGCTTTAGCGGCATGAACCGCTTCAACTCTCGAACCTACTCCAAATTC
AAGAACTCCCTGGTGGTCTCTTTCCTCAGCTACTGTGACTACTACCGGCCCCGCTACTTC
CTCTTGGAGAACGTTCGGAACTTCGTCTCCTTCAAGCGCTCCATGGTCCTGAAGCTGACG
CTGCGCTGCCTGGTCCGCAGGGGGTACCAGTGCACCTTTGGCGTGCTGCAGGCTGGTCAG
TACGGCGTGGCCCAGACTCGGAGGCGAGCCATCATCCTGGCTGCAGCCCCTGGGGAGCCA
CTCCCGCTGTTCCCGGAGCCGTTGCATGTGTTCGCACCCCGGGCCTGCCAGCTGAGCGTC
GTAGTGGACGACAAGAAGTTTGTCAGCAACATCACCAGGTTGAGCTCGGGTCCCTTCCGA
ACCATCACCGTGCGGGACACCATGTCTGACCTCCCTGAGATCCGGAACGGGGCCTCGGCA
CTGGAGATTTCATACAACCGGGAGCCCCAGTCCTGGTTCCAGAGGCAGCTCCGGGGCTCG
CAGTACCAGCCCATCCTCAGGGATCATATTTGCAAGGACATGAGCGCCTTGGTGGCTGCC
CGCATGCGGCACATCCCCCTGGCCCCGGGCTCGGACTGGCGTGACCTGCCCAACATTGAG
GTGCGGCTCTCTGACGGCACCCTGGCCCGGAAGCTGCGGTACAACTACCACGACAAGAAG
AACGGCTGCAGCAGCAGCGGCGCCCTCCGTGGGGTCTGCTCCTGTGTGGAAGGCAAGCCC
TGTGAGCCTGCGGCCCGACAGTTTAACACCCTTATCCCCTGGTGCCTGCCCCACACTGGG
AACAGGCACAACCACTGGGCCGGCCTCTACGGGCGTCTCGAGTGGGACGGCTTCTTCAGC
ACAACTGTCACCAACCCCGAGCCCATGGGCAAGCAGGGCCGCGTGCTCCACCCCGAGCAG
CACCGAGTGGTGAGCGTCCGGGAGTGCGCCCGCTCCCAGGGCTTCCCCGACACCTATCGG
CTGTTCGGCAACATCCTAGACAAGCACCGGCAGGTGGGTAATGCTGTGCCGCCGCCACTG
GCCAAAGCCATCGGCTTGGAGATCAAGCGCTGCATGTTGGCCAAAGCGCGCGAGAGCGCC
TCAGCTAAAATCAAGGAGGAGGCTGCCAAGGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1611 |
| Molecular Weight
| 182842.0 |
| Theoretical pI
| 7.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA (cytosine-5)-methyltransferase 1
MPARTAPARVPALASRAFSLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLRTEIKNQ
LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSREANGCLENGSQTSGEDCRV
VMAEKGKPPKPVSRLYTPRRSKSDGETKSEVSSSPRITRKTTRQTTITSHFPRGPAKRKP
EEEPEKVKSDDSVDEEKDQEEKRRRVTSRERVAGLLPAEEPGRVRPGTHMEEEGRDDKEE
KRLRSQTKEPTPKHKAKEEPDRDVRPGGAQAEMNEGEDKDEKRHRSQPKDLASKRRPEEK
EPERVKPQVSDEKDEDEKEEKRRRTTYRELTEKKMTRTKIAVVSKTNPPKCTECLQYLDD
PELRYEQHPPDAVEEIQILTNERLSIFDANESGFESYEDLPQHKLTCFSVYCKRGHLCPI
DTGLIEKDVELLFSGSAKPIYEDDPSPEGGINGKNFGPINEWWIAGFDGGEKALLGFSTS
FAEYILMDPSPEYAPLFSVMQEKIYISKIVVEFLQSNPDSTYEDLINKIETTVPPCMLNL
NRFTEDSLLRHAQFVVEQVESYDRAGDSDEQPIFLSPCMRDLIKLAGVTLGKRRAERRQT
IRQPAKEKDKGPTKATTTKLVYQIFDTFFAEQIEKDDKEDKENAFKRRRCGVCEICQQPE
CGKCKACKDMVKFGGSGRSKQACQKRRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKK
KKQNKNRISWVGDAVKTDGKKSYYKKVCIDSETLEVGDCVSVIPDDSSKPLYLARVTALW
EDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVQVIYKAPSENW
AMEGGVDPEALMSEDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKYKFCASCARLAEMR
QKEIPRVVEQLQDLEGRVLYSLATKNGVQYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEP
VDEALYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCSKKSNGRPNETDIKIRVNKFYR
PENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPQCLQDFSAGGPDRF
YFLEAYNAKSKSFEDPPNHARSTGNKGKGKGKGKNRTKSQTCEPSELETEIKLPKLRTLD
VFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGSTVFTEDCNVLLKLVMAGEV
TNSRGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRYF
LLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEP
LPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEIRNGASA
LEISYNGEPQSWFQRQLRGSQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIE
VRLSDGTLARKLRYNYHDKKNGCSSSGALRGVCSCVEGKPCEPAARQFNTLIPWCLPHTG
NRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYR
LFGNILDKHRQVGNAVPPPLAKAIGLEIKRCMLAKARESASAKIKEEAAKD
|
| External Links |
|---|
| GenBank ID Protein
| AAP20551.1 |
| UniProtKB/Swiss-Prot ID
| Q24K09 |
| UniProtKB/Swiss-Prot Entry Name
| DNMT1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY244709 |
| GeneCard ID
| DNMT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
