Showing Protein DNA (cytosine-5)-methyltransferase 1 (BMDBP00407)
| Identification | |||
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| BMDB Protein ID | BMDBP00407 | ||
| Secondary Accession Numbers |
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| Name | DNA (cytosine-5)-methyltransferase 1 | ||
| Synonyms | Not Available | ||
| Gene Name | DNMT1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Replication, recombination and repair | ||
| Specific Function | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth. | ||
| Pathways | Not Available | ||
| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 7 | ||
| Locus | 7q15 | ||
| SNPs | DNMT1 | ||
| Gene Sequence |
>4836 bp ATGCCTGCCCGAACCGCCCCGGCGCGGGTGCCTGCGCTGGCCTCCCGGGCCTTCTCACTG CCTGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGATAGTTTGACAGAAAAGGAA TGTGTGAAGGAGAAACTGAATCTCTTGCACGAATTTCTGCGGACAGAAATAAAGAATCAG TTATGTGATTTGGAAACCAAATTGCATAAAGAAGAATTATCTGAGGAGGGCTACCTGGCT AAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGAGCTCATGCTTTCAGT CGGGAAGCGAATGGATGTCTAGAGAACGGGAGCCAGACAAGTGGTGAGGATTGCAGAGTG GTAATGGCAGAGAAAGGCAAGCCCCCCAAACCTGTCTCCAGACTTTACACGCCCAGGAGA AGCAAGTCTGATGGAGAAACAAAGTCTGAAGTCTCTTCTAGCCCCAGGATTACAAGGAAG ACTACCAGGCAGACCACCATCACATCTCATTTCCCACGGGGCCCTGCCAAACGAAAACCT GAGGAAGAACCTGAAAAAGTGAAGTCAGACGATTCTGTTGATGAAGAAAAAGACCAGGAG GAAAAGAGACGTCGAGTTACATCCAGAGAACGAGTTGCTGGGCTGCTCCCTGCAGAAGAA CCAGGAAGAGTAAGACCAGGAACACACATGGAAGAAGAAGGAAGAGATGATAAAGAAGAA AAGAGACTCAGAAGTCAAACCAAAGAACCGACACCTAAACACAAAGCTAAGGAGGAGCCA GACAGAGATGTGAGGCCTGGAGGAGCTCAGGCTGAAATGAATGAAGGAGAAGACAAAGAT GAAAAGAGGCACAGAAGTCAACCCAAAGATCTAGCTAGCAAACGGAGACCAGAAGAAAAA GAACCTGAAAGAGTAAAGCCACAAGTTTCTGATGAGAAAGATGAAGATGAAAAGGAGGAG AAGAGACGCAGAACTACATACAGAGAACTAACCGAGAAGAAAATGACTCGAACCAAAATA GCCGTAGTGTCCAAGACCAATCCTCCGAAGTGCACCGAGTGCTTGCAGTACCTGGACGAC CCTGAGCTGAGATACGAGCAGCACCCCCCCGATGCGGTGGAAGAGATACAGATACTGACC AACGAGAGGTTGTCCATCTTTGATGCCAACGAATCTGGCTTTGAGAGTTACGAGGATTTG CCTCAGCACAAACTAACCTGCTTCAGCGTGTACTGTAAACGCGGTCACCTTTGCCCGATC GACACCGGCCTCATTGAGAAGGATGTCGAGCTCCTCTTTTCTGGTTCAGCAAAGCCGATA TATGAGGATGACCCATCTCCCGAAGGTGGTATTAATGGCAAAAATTTTGGCCCCATAAAC GAATGGTGGATTGCTGGTTTTGATGGAGGTGAAAAGGCTCTTCTTGGCTTTAGCACCTCA TTTGCCGAGTATATCTTGATGGATCCCAGCCCAGAGTACGCACCACTATTCAGCGTGATG CAGGAGAAGATCTATATAAGTAAGATAGTGGTTGAGTTCCTGCAGAGCAACCCTGACTCC ACCTACGAAGACCTGATCAATAAGATTGAGACCACCGTTCCTCCTTGTATGCTCAACTTG AATCGATTCACAGAGGATTCTCTCCTGCGGCATGCCCAGTTCGTGGTGGAGCAAGTAGAG AGTTATGATCGGGCTGGGGACAGTGACGAGCAGCCCATCTTCCTGAGCCCCTGCATGAGA GACCTCATCAAGCTGGCCGGGGTCACCCTGGGAAAAAGGCGAGCCGAGAGGCGGCAGACC ATCCGGCAACCCGCCAAAGAGAAGGACAAGGGCCCCACCAAGGCCACCACCACCAAGCTG GTCTACCAGATCTTTGACACTTTCTTTGCGGAGCAAATTGAAAAAGATGACAAGGAAGAC AAGGAGAATGCCTTCAAGCGCCGGCGCTGTGGCGTCTGTGAGATTTGTCAACAGCCCGAG TGTGGAAAGTGTAAGGCCTGTAAGGATATGGTTAAATTTGGTGGTAGCGGACGGAGCAAG CAGGCTTGCCAAAAGAGGAGGTGTCCCAACATGGCCATGAAGGAGGCAGACGATGACGAG GAAGTGGATGACAATATTCCAGAGATGCCATCACCCAAAAAGATGCATCAGGGGAAGAAA AAGAAGCAGAATAAGAATCGGATCTCTTGGGTTGGCGATGCCGTCAAGACTGACGGGAAG AAGAGTTACTACAAGAAGGTATGCATCGACTCGGAAACCCTGGAAGTGGGGGACTGTGTT TCTGTAATTCCAGACGACTCTTCAAAACCACTGTATCTAGCAAGGGTCACGGCGCTGTGG GAGGACAGCAGCAATGGGCAGATGTTCCATGCCCACTGGTTCTGTGCTGGGACGGACACG GTCCTCGGGGCCACATCGGACCCCCTGGAGCTGTTCCTGGTTGACGAGTGTGAGGACATG CAGCTCTCGTACATCCACAGCAAGGTGCAGGTCATTTATAAGGCGCCCTCAGAGAACTGG GCCATGGAGGGAGGCGTGGACCCCGAGGCCCTGATGTCAGAGGACGACGGGAAGACCTAC TTCTACCAGCTGTGGTACGACCAAGACTACGCGAGATTTGAGTCCCCTCCGAAAACTCAG CCGACGGAGGACAACAAGTACAAGTTCTGCGCAAGCTGTGCACGTCTGGCCGAAATGAGG CAGAAGGAAATCCCCAGGGTCGTGGAGCAGCTCCAGGACCTGGAAGGCCGCGTCCTCTAC AGCCTCGCCACCAAGAACGGCGTCCAGTACCGGGTGGGCGATGGCGTGTACCTCCCTCCC GAGGCCTTCACCTTCAACATCAAGCTGTCCAGTCCTGTGAAACGCCCCCGGAAGGAGCCT GTGGACGAAGCTCTGTATCCAGAACACTACCGGAAGTACTCTGACTACATCAAGGGCAGC AACCTGGATGCCCCTGAGCCCTACCGTATTGGCCGCATAAAGGAGATCTTCTGCAGCAAG AAGAGCAACGGCCGGCCCAATGAGACAGACATCAAGATCAGGGTCAACAAGTTCTACAGG CCGGAGAACACACACAAGTCTACCCCAGCCAGTTACCACGCAGACATCAACCTGCTTTAC TGGAGCGATGAGGAGGCCGTGGTGGACTTCAAGGCCGTGCAGGGCCGCTGCACCGTGGAG TACGGAGAGGACCTGCCTCAGTGCCTCCAGGACTTCTCCGCTGGTGGCCCCGATCGCTTC TATTTTCTCGAGGCCTATAACGCCAAGAGCAAAAGCTTTGAAGATCCTCCGAACCACGCC CGGAGCACCGGAAATAAAGGGAAAGGGAAGGGGAAAGGAAAAAACAGGACGAAATCTCAG ACGTGTGAGCCGAGTGAACTGGAGACAGAAATCAAACTGCCGAAGCTGCGGACCCTGGAC GTGTTTTCCGGCTGTGGGGGATTGTCGGAAGGCTTCCACCAAGCAGGCATCTCGGAAACA CTTTGGGCCATCGAGATGTGGGACCCTGCGGCCCAGGCGTTCCGGTTCAACAACCCTGGG TCCACGGTGTTCACAAAGGACTGCAACGTCCTGGTGAAGCTGGTCATGGCCGGGGAGGTG ACCAACTCCCGCGGCCAGAAGCTGCTTCAAAAGGGAGATGTGGAGATGTTGTGCGGCGGG CCGCCCTGCCAGGGCTTTAGCGGCATGAACCGCTTCAACTCTCGAACCTACTCCAAATTC AAGAACTCCCTGGTGGTCTCTTTCCTCAGCTACTGTGACTACTACCGGCCCCGCTACTTC CTCTTGGAGAACGTTCGGAACTTCGTCTCCTTCAAGCGCTCCATGGTCCTGAAGCTGACG CTGCGCTGCCTGGTCCGCAGGGGGTACCAGTGCACCTTTGGCGTGCTGCAGGCTGGTCAG TACGGCGTGGCCCAGACTCGGAGGCGAGCCATCATCCTGGCTGCAGCCCCTGGGGAGCCA CTCCCGCTGTTCCCGGAGCCGTTGCATGTGTTCGCACCCCGGGCCTGCCAGCTGAGCGTC GTAGTGGACGACAAGAAGTTTGTCAGCAACATCACCAGGTTGAGCTCGGGTCCCTTCCGA ACCATCACCGTGCGGGACACCATGTCTGACCTCCCTGAGATCCGGAACGGGGCCTCGGCA CTGGAGATTTCATACAACCGGGAGCCCCAGTCCTGGTTCCAGAGGCAGCTCCGGGGCTCG CAGTACCAGCCCATCCTCAGGGATCATATTTGCAAGGACATGAGCGCCTTGGTGGCTGCC CGCATGCGGCACATCCCCCTGGCCCCGGGCTCGGACTGGCGTGACCTGCCCAACATTGAG GTGCGGCTCTCTGACGGCACCCTGGCCCGGAAGCTGCGGTACAACTACCACGACAAGAAG AACGGCTGCAGCAGCAGCGGCGCCCTCCGTGGGGTCTGCTCCTGTGTGGAAGGCAAGCCC TGTGAGCCTGCGGCCCGACAGTTTAACACCCTTATCCCCTGGTGCCTGCCCCACACTGGG AACAGGCACAACCACTGGGCCGGCCTCTACGGGCGTCTCGAGTGGGACGGCTTCTTCAGC ACAACTGTCACCAACCCCGAGCCCATGGGCAAGCAGGGCCGCGTGCTCCACCCCGAGCAG CACCGAGTGGTGAGCGTCCGGGAGTGCGCCCGCTCCCAGGGCTTCCCCGACACCTATCGG CTGTTCGGCAACATCCTAGACAAGCACCGGCAGGTGGGTAATGCTGTGCCGCCGCCACTG GCCAAAGCCATCGGCTTGGAGATCAAGCGCTGCATGTTGGCCAAAGCGCGCGAGAGCGCC TCAGCTAAAATCAAGGAGGAGGCTGCCAAGGACTAG |
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| Protein Properties | |||
| Number of Residues | 1611 | ||
| Molecular Weight | 182842.0 | ||
| Theoretical pI | 7.77 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>DNA (cytosine-5)-methyltransferase 1 MPARTAPARVPALASRAFSLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLRTEIKNQ LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSREANGCLENGSQTSGEDCRV VMAEKGKPPKPVSRLYTPRRSKSDGETKSEVSSSPRITRKTTRQTTITSHFPRGPAKRKP EEEPEKVKSDDSVDEEKDQEEKRRRVTSRERVAGLLPAEEPGRVRPGTHMEEEGRDDKEE KRLRSQTKEPTPKHKAKEEPDRDVRPGGAQAEMNEGEDKDEKRHRSQPKDLASKRRPEEK EPERVKPQVSDEKDEDEKEEKRRRTTYRELTEKKMTRTKIAVVSKTNPPKCTECLQYLDD PELRYEQHPPDAVEEIQILTNERLSIFDANESGFESYEDLPQHKLTCFSVYCKRGHLCPI DTGLIEKDVELLFSGSAKPIYEDDPSPEGGINGKNFGPINEWWIAGFDGGEKALLGFSTS FAEYILMDPSPEYAPLFSVMQEKIYISKIVVEFLQSNPDSTYEDLINKIETTVPPCMLNL NRFTEDSLLRHAQFVVEQVESYDRAGDSDEQPIFLSPCMRDLIKLAGVTLGKRRAERRQT IRQPAKEKDKGPTKATTTKLVYQIFDTFFAEQIEKDDKEDKENAFKRRRCGVCEICQQPE CGKCKACKDMVKFGGSGRSKQACQKRRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKK KKQNKNRISWVGDAVKTDGKKSYYKKVCIDSETLEVGDCVSVIPDDSSKPLYLARVTALW EDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVQVIYKAPSENW AMEGGVDPEALMSEDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKYKFCASCARLAEMR QKEIPRVVEQLQDLEGRVLYSLATKNGVQYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEP VDEALYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCSKKSNGRPNETDIKIRVNKFYR PENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPQCLQDFSAGGPDRF YFLEAYNAKSKSFEDPPNHARSTGNKGKGKGKGKNRTKSQTCEPSELETEIKLPKLRTLD VFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGSTVFTEDCNVLLKLVMAGEV TNSRGQKLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRYF LLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEP LPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEIRNGASA LEISYNGEPQSWFQRQLRGSQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIE VRLSDGTLARKLRYNYHDKKNGCSSSGALRGVCSCVEGKPCEPAARQFNTLIPWCLPHTG NRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYR LFGNILDKHRQVGNAVPPPLAKAIGLEIKRCMLAKARESASAKIKEEAAKD |
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| External Links | |||
| GenBank ID Protein | AAP20551.1 | ||
| UniProtKB/Swiss-Prot ID | Q24K09 | ||
| UniProtKB/Swiss-Prot Entry Name | DNMT1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AY244709 | ||
| GeneCard ID | DNMT1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||