Showing Protein Protein arginine N-methyltransferase 5 (BMDBP00411)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00411 |
| Secondary Accession Numbers | None |
| Name | Protein arginine N-methyltransferase 5 |
| Synonyms | Not Available |
| Gene Name | PRMT5 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in histone-arginine N-methyltransferase activity |
| Specific Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (By similarity). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner. Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression. Symmetrically methylates NCL (By similarity). Methylates TP53; methylation might possibly affect TP53 target gene specificity (By similarity). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein B) and the interaction with tudor domain-containing protein TDRD6 (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | PRMT5 |
| Gene Sequence |
>1914 bp ATGGCGGCGATGGCGGTCGGTGGTGCCGGTGGAAGCCGCGTGTCCAGCGGGAGGGACCTG AATTGCGTCCCCGAAATAGCTGACACACTGGGGGCTGTGGCCAAGCAGGGGTTTGATTTC CTCTGCATGCCTGTGTTCCACCCGCGTTTCAAGAGGGAATTCACTCAGGAACCTGCTAAG AGTCGGCCGGGCCCCCAGACACGATCAGACCTACTGCTGTCAGGAAGGGACTGGAATACA CTAATTGTGGGAAAGCTTTCTCCATGGATTCGTCCAGACTCAAAAGTGGAGAAGATACGC AGGAACTCTGAGGCGGCTATGTTACAGGAGCTGAATTTTGGGGCATATTTGGGTCTTCCA GCTTTCCTGCTGCCCCTAAATCAGGAAGATAACACAAACTTGGCGAGAGTTTTGACCAAT CACATCCACACTGGCCACCACTCCTCCATGTTCTGGATGCGGGTGCCATTGGTGGCACCA GAGGACCTGAGAGATGATATAATTGAGAACGCACCAACTTCACACACAGAGGAGTACAGT GGAGAGGAGAAGACATGGATGTGGTGGCACAACTTCCGGACCTTATGTGATTACAGCAAG AGGATTGCAGTGGCTCTTGAAATTGGTGCTGACCTCCCATCTAATCATGTCATTGATCGT TGGCTTGGGGAGCCCATCAAAGCAGCCATTCTCCCCACTAGCATTTTCCTGACCAATAAG AAGGGATTTCCTGTTCTTTCTAAGATGCACCAGAGGTTGATCTTCCGACTTCTCAAGTTG GAGGTACAGTTCATCATCACAGGCACCAACCACCACTCAGAGAAGGAGTTCTGCTCCTAC CTCCAATACTTGGAATACCTGAGCCAGAACCGACCTCCACCCAATGCCTACGAACTCTTT GCCAAGGGCTATGAAGATTACCTGCAGTCCCCACTCCAGCCACTGATGGATAACCTGGAA TCTCAGACATACGAAGTGTTCGAAAAGGACCCCATCAAATACTCTCAGTACCAGCAGGCC ATCTATAAATGTCTGTTAGATCGAGTGCCAGAGGAAGAGAAGGACACCAATATCCAAGTG CTGATGGTGCTGGGAGCAGGCCGGGGGCCCCTGGTGAATGCTTCCCTGCGGGCCGCCAAG CAGGCTGACCGGCGGATAAAATTGTACGCTGTGGAGAAGAACCCAAATGCTGTGGTGACG TTGGAGAACTGGCAGTTTGAAGAATGGGGAAGCCAGGTGACAGTAGTCTCATCGGACATG CGGGAGTGGGTGGCTCCAGAGAAAGCAGATATCATTGTCAGTGAGCTTCTGGGGTCCTTT GCTGACAATGAACTGTCACCTGAGAGCCTGGATGGAGCCCAGCACTTCCTAAAAGATGAT GGCGTGAGCATTCCTGGGGAGTACACCTCCTTTCTAGCTCCCATCTCCTCCTCCAAGCTA TACAATGAGGTCCGAGCCTGTCGGGAAAAGGACCGTGACCCTGAGGCCCAGTTTGAGATG CCTTATGTGGTACGACTGCACAATTTCCACCAGCTGTCTGCACCCCAGCCCTGTTTTACC TTCAGCCATCCTAACAGAGATCCTATGATTGACAACAATCGCTACTGTACCTTGGAGTTT CCTGTGGAGGTGAACACAGTGCTGCATGGTTTTGCAGGCTACTTTGAGACTGTGCTTTAT CAGGACATCACTCTGAGTATCCGTCCAGAGACTCACTCTCCTGGGATGTTTTCATGGTTT CCCATCCTCTTCCCCATTAAGCAGCCCATTACGGTGCGTGAAGGCCAGACCATCTGTGTG CGTTTCTGGCGATGCAGCAACTCTAAGAAGGTGTGGTATGAGTGGGCTGTGACGGCACCG GTCTGCTCTGCTATTCACAACCCCACAGGCCGCTCTTACACCATTGGCCTCTAG |
| Protein Properties | |
| Number of Residues | 637 |
| Molecular Weight | 72629.0 |
| Theoretical pI | 6.24 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Protein arginine N-methyltransferase 5 MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFTQEPAK SRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTSHTEEYS GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNIQV LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM REWVAPEKADIIVSELLGSFADNELSPESLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL |
| External Links | |
| GenBank ID Protein | AAI34450.1 |
| UniProtKB/Swiss-Prot ID | A7YW45 |
| UniProtKB/Swiss-Prot Entry Name | ANM5_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC134449 |
| GeneCard ID | PRMT5 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |