| Identification |
|---|
| BMDB Protein ID
| BMDBP00412 |
| Secondary Accession Numbers
| None |
| Name
| Guanidinoacetate N-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| GAMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in guanidinoacetate N-methyltransferase activity |
| Specific Function
| Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development. |
| Pathways
|
- Amine and polyamine biosynthesis
- Arginine and Proline Metabolism
- Creatine biosynthesis
- Creatine from L-arginine and glycine: step 2/2
- Glycine and Serine Metabolism
|
| Reactions
|
| S-Adenosylmethionine + Guanidoacetic acid → S-Adenosylhomocysteine + Creatine |
details
|
| Guanidoacetic acid + S-Adenosylhomocysteine → S-Adenosylmethionine + Creatine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| GAMT |
| Gene Sequence
|
>711 bp
ATGAGCGCACCCGCCGCGACCCCAATCTTCGCGCCCGGCGAGAACTGCAGCCCCGCATGG
CGGGCTGCGCCCGCGGCCTACGACGCGTCGGACACGCACCTGCAGATCCTGGGCAAGCCG
GTGATGGAGCGCTGGGAGACCCCCTACATGCACGCGCTGGCGGCCGCCGCCGCCTCCAGA
GGGGGCCGGGTGCTAGAAGTGGGCTTCGGCATGGCCATCGCAGCCACAAAGGTGCAGGAG
GCTCCCATCGAGGAGCACTGGATTATTGAGTGCAACGAGGGCGTCTTCCAGCGGCTCCAG
GATTGGGCCCTGCAGCAGCCACACAAGGTGGTTCCCTTGAAAGGCCTGTGGGAGGAGGTG
GCACCCACCCTGCCAGACAGTCACTTTGATGGGATCCTGTACGATACATACCCGCTGTCG
GAGGAGACCTGGCACACTCACCAGTTCAACTTCATTCGGGACCATGCCTTCCGCCTGCTG
AAGCCAGGGGGTGTCCTCACCTACTGTAACCTCACCTCCTGGGGAGAGCTAATGAAGACC
AAGTATTCAGACATCACCACCATGTTTGAGGAGACCCAGGTGCCGGCCCTGCTGGAGGCG
GGCTTCCGGCGGGATAACATCCGCACACAGGTCATGGAGCTGGTCCCACCAGCCAACTGC
CGCTACTACGCCTTCCCGCGGATGATCACGCCCCTGGTCACCAAGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 236 |
| Molecular Weight
| 26610.0 |
| Theoretical pI
| 6.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Guanidinoacetate N-methyltransferase
MSAPAATPIFAPGENCSPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAAAASR
GGRVLEVGFGMAIAATKVQEAPIEEHWIIECNEGVFQRLQDWALQQPHKVVPLKGLWEEV
APTLPDSHFDGILYDTYPLSEETWHTHQFNFIRDHAFRLLKPGGVLTYCNLTSWGELMKT
KYSDITTMFEETQVPALLEAGFRRDNIRTQVMELVPPANCRYYAFPRMITPLVTKH
|
| External Links |
|---|
| GenBank ID Protein
| AAI09826.1 |
| UniProtKB/Swiss-Prot ID
| Q2TBQ3 |
| UniProtKB/Swiss-Prot Entry Name
| GAMT_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC109825 |
| GeneCard ID
| GAMT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
