Showing Protein Guanidinoacetate N-methyltransferase (BMDBP00412)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 metabolites
Identification
BMDB Protein ID BMDBP00412
Secondary Accession Numbers None
Name Guanidinoacetate N-methyltransferase
Synonyms Not Available
Gene Name GAMT
Protein Type Enzyme
Biological Properties
General Function Involved in guanidinoacetate N-methyltransferase activity
Specific Function Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.
Pathways
  • Amine and polyamine biosynthesis
  • Arginine and Proline Metabolism
  • Creatine biosynthesis
  • Creatine from L-arginine and glycine: step 2/2
  • Glycine and Serine Metabolism
Reactions
S-Adenosylmethionine + Guanidoacetic acid → S-Adenosylhomocysteine + Creatine details
Guanidoacetic acid + S-Adenosylhomocysteine → S-Adenosylmethionine + Creatine details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 7
Locus Not Available
SNPs GAMT
Gene Sequence 
>711 bp
ATGAGCGCACCCGCCGCGACCCCAATCTTCGCGCCCGGCGAGAACTGCAGCCCCGCATGG
CGGGCTGCGCCCGCGGCCTACGACGCGTCGGACACGCACCTGCAGATCCTGGGCAAGCCG
GTGATGGAGCGCTGGGAGACCCCCTACATGCACGCGCTGGCGGCCGCCGCCGCCTCCAGA
GGGGGCCGGGTGCTAGAAGTGGGCTTCGGCATGGCCATCGCAGCCACAAAGGTGCAGGAG
GCTCCCATCGAGGAGCACTGGATTATTGAGTGCAACGAGGGCGTCTTCCAGCGGCTCCAG
GATTGGGCCCTGCAGCAGCCACACAAGGTGGTTCCCTTGAAAGGCCTGTGGGAGGAGGTG
GCACCCACCCTGCCAGACAGTCACTTTGATGGGATCCTGTACGATACATACCCGCTGTCG
GAGGAGACCTGGCACACTCACCAGTTCAACTTCATTCGGGACCATGCCTTCCGCCTGCTG
AAGCCAGGGGGTGTCCTCACCTACTGTAACCTCACCTCCTGGGGAGAGCTAATGAAGACC
AAGTATTCAGACATCACCACCATGTTTGAGGAGACCCAGGTGCCGGCCCTGCTGGAGGCG
GGCTTCCGGCGGGATAACATCCGCACACAGGTCATGGAGCTGGTCCCACCAGCCAACTGC
CGCTACTACGCCTTCCCGCGGATGATCACGCCCCTGGTCACCAAGCACTGA
Protein Properties
Number of Residues 236
Molecular Weight 26610.0
Theoretical pI 6.03
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Guanidinoacetate N-methyltransferase
MSAPAATPIFAPGENCSPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAAAASR
GGRVLEVGFGMAIAATKVQEAPIEEHWIIECNEGVFQRLQDWALQQPHKVVPLKGLWEEV
APTLPDSHFDGILYDTYPLSEETWHTHQFNFIRDHAFRLLKPGGVLTYCNLTSWGELMKT
KYSDITTMFEETQVPALLEAGFRRDNIRTQVMELVPPANCRYYAFPRMITPLVTKH
GenBank ID Protein AAI09826.1
UniProtKB/Swiss-Prot ID Q2TBQ3
UniProtKB/Swiss-Prot Entry Name GAMT_BOVIN
PDB IDs
GenBank Gene ID BC109825
GeneCard ID GAMT
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available