Showing Protein Methionine synthase (BMDBP00414)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00414 | ||
| Secondary Accession Numbers | None | ||
| Name | Methionine synthase | ||
| Synonyms | Not Available | ||
| Gene Name | MTR | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Amino acid transport and metabolism | ||
| Specific Function | Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 28 | ||
| Locus | Not Available | ||
| SNPs | MTR | ||
| Gene Sequence |
>3798 bp ATGGCCCCCACGCTCCAGGACCTGACGCCATCTGCAGGGATGAAGAAGACCCTGCAAGAT GAGATTGAAGCTATCCTGCAGGAGAGGATTATGGTGCTTGATGGAGGGATGGGGACCATG ATCCAGCGGCACAAGCTGAGTGAAGAAGACTTCCGAGGACAAGAATTTAAAGATCATGCC AGGCCCCTGAAAGGCAACAATGACATTTTAAGTATAACTCAGCCCAATGTCATTTACCAA ATCCATAAGGAGTACCTCCTAGCTGGGGCAGATATCATTGAAACAAATACTTTCAGCAGC ACTTCTATTGCCCAAGCTGACTATGGCCTGGAACACTTGGCCTACCGGATGAACATGTGC TCTGCGGGAGTGGCCAGAAAAGCAGCCGAGGACATCTCTCTCCAGACAGGAATTAAGAGG TATGTGGCAGGAGCTCTGGGTCCAACTAACAAGACACTCTCTGTGTCGCCATCTGTGGAA AGACCAGATTACAGGAACATCACATTTGATGAACTTGTTGAAGCATACAAAGAGCAGGCC AAAGGGCTTCTGGATGGTGGAGTGGATATCTTACTCATTGAAACTATTTTTGATACCGCC AATGCCAAGGCAGCCTTGTTTGCAGTCCAAAAACTTTTTGAAGAGGAGTATGTTCCCCGG CCTGTCTTTATTTCAGGGACAATTGTTGATAAAAGTGGGCGGACTCTCTCTGGCCAGACT GGGGAGGCATTTGTCATCAGCGTGTCTCATGCAGACCCACTCTGCATTGGATTAAATTGT GCTCTGGGTGCAGCTGAAATGAGACCTTTTATTGAAACAATTGGAAAATGTACAACAGCT TATGTTCTCTGTTATCCCAATGCAGGTCTTCCCAATACCTTCGGTGACTATGATGAAACT CCCCACGTGATGGCCATGCATTTAAAGGATTTTGCTGTTGATGGCTTGGTCAACATAGTT GGCGGATGCTGTGGTACGACACCAGATCATATCAGAGAAATTGCTGAAGCTGTGAAAAAC TGTAAGCCTAGAGTTCCACCTGCCACTGTTTTCGAAGGGCATATGCTACTGTCTGGTCTA GAGCCCTTCAGGATTGGACCATACACCAACTTTGTTAACATTGGAGAGCGCTGTAACGTT GCAGGATCCAGGAGATTTGCTAAGCTCATCATGGCAGGAAATTATGAAGAAGCACTGAGC GTTGCCAAAATGCAGGTGGAAATGGGAGCCCAGGTGTTGGATATTAACATGGATGATGGC ATGCTGGATGGTCCAAGTGCAATGACCAGATTCTGCAACTTCATTGCTTCCGAGCCTGAC ATTGCCAAGGTGCCCTTGTGCATTGACTCTTCCAATTTTGCTGTGATTGAAGCCGGCTTA AAGTGCTGCCAGGGGAAGTGCATTGTTAATAGCATCAGCTTGAAGGAGGGAGAGGATGAC TTCTTGGAGAAGGCCAGAAAGATTAAGAAGTTTGGAGCTGCCGTGGTGGTTATGGCTTTT GATGAAGAAGGACAGGCAACAGAAACAGATCCCAAAATCAGAGTGTGCACCCGGGCCTAC CATCTCCTTTTGAAAAAACTGGGCTTCAATCCAAATGACATCATCTTTGACCCTAATATC CTCACCATTGGTACTGGGATGGAAGAACATAACTTGTATGCTGTTAATTTTATCAATGCA ACAAAAGTCATTAAAGAAACGCTGCCTGGAGCCAAAGTAAGCGGTGGTCTTTCCAACTTG TCCTTCTCCTTCCGAGGAATGGAAGCCATTCGAGAGGCAATGCATGGGGTTTTCCTGTAC CATGCGATCAAGTTTGGTATGGACATGGGAATAGTGAATGCTGGAAGCCTTCCTGTATAT GATGACATCCACAAGGAGCTTCTCCAGCTCTGTGAGGACCTCATCTGGAACAGAGACCCT GAGGCCACCGAGAAGCTCTTACACTACGCCCAGACTCAGGGCAAAGGAGGGAAGAAAGTC ATCCAGACTGATGAGTGGAGGAATGGCCCTCTCGAAGAACGCCTTGAGTACGCTCTTGTG AAGGGCATTGAAAAATATATTATTGAAGATACTGAGGAAGCCAGGTTAAACCAGGAAAAA TATCCCCGACCTCTGAATATAATTGAAGGGCCGCTGATGAATGGCATGAAAATTGTTGGT GATCTTTTTGGAGCTGGAAAAATGTTTCTACCTCAGGTTATAAAGTCAGCTCGGGTCATG AAGAAGGCCGTGGGTCACCTTATTCCCTTCATGGAAAAAGAGAGAGAAGAAACCAAAGTG CTTACTGGCAAAATAGAAGATGAGGACCCTTACCAAGGCACCATCGTGCTGGCTACTGTT AAAGGTGACGTACACGACATAGGCAAGAACATAGTTGGAGTGGTTCTTGGCTGCAATAAT TTCAGAGTTATTGATTTAGGAGTCATGACTCCATGTGACAAGATACTGAAGGCTGCTCTA GACCACAAAGCAGATATAATTGGCCTGTCAGGACTCATCACTCCTTCCCTGGATGAAATG ATTTTTGTCGCTAAGGAAATGGAGAGACTAGCTATAAAGATCCCATTGTTGATCGGAGGA GCTACCACTTCCAGAACCCACACAGCAGTTAAAATAGCCCCAAGATACAGTGCGCCCGTG ATCCACGTCCTGGATGCATCCAAGAGCGTGGTGGTGTGTTCTCAACTGTTAGATGAGAAT CTAAAAGATGAGTACTTTGAGGAGATCCTGGAAGAATATGAAGATATTAGACAGGACCAT TATGAATCTCTCAAGGAGAGAAGATACTTAACCTTAAGGCAAGCTAGAGAAAATGGTTTC CATATTGACTGGCTGTCAGAGCCTCCTCCAGTGAAGCCCACGTTCCTCGGGACTCGGGTC TTTGAAGACTACGACCTGCAGAAGCTGGTGGACTACATTGATTGGAAGCCTTTCTTCGAC GTCTGGCAGCTCCGGGGCAAATACCCGAACCGAGGCTTTCCCAAGATATTTGACGACAAA ACTGTAGGTGAAGAGGCCAAAAAGGTCTATGATGATGCCCAAAATATGCTGCAGGCACTG ATCAGTCAGAAGAAGCTCCAGGCCAGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGCATT CAGGATGATATCCACCTGTACGCGGAAGGCGCAGTGCCACAGGCCTCGGAGCCCATAGCC ACCTTCTACGGGCTCAGGCAGCAGGCCGAGAAGGACTCTGCCAGCTCGGACCCCTACCTC TGCCTCTCGGACTTCATCGCCCCTCTGCACTCAGGTATCCCCGACTACCTGGGCCTGTTC GCCGTTGCCTGCTTTGGGGTGGAGGAGCTGAGCAAGGCCTACGAGGAGGAGTGTGATGAC TACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTGGCCGAGGCCTTCGCTGAGGAG CTGCACGAGCGGGCCCGCAGGGAGCTGTGGGGTTACTGTAGTGGTGAGCAGCTGGCTGTG GCTGACCTGCGGAGACTGCGCTACGAGGGCATCCGGCCGGCGCCCGGCTATCCCAGCCAG CCTGACCACACTGAGAAGCTGACCGTGTGGAGGCTGGCGGACGTGGAGCAGCGCACAGGC ATTAGGTTAACAGAATCGCTGGCCATGGCACCTGCTTCAGCAGTATCTGGCCTTTACTTC TCCAACTTGAAGTCCAAGTATTTTGCCGTGGGGAAAATTTCCAAGGATCAGATTGAGGAT TATGCTTCGAGGAAGAACATGTCTGTGGCCGAGGTTGAGAAATGGCTTGGACCCATTTTG GGATATGATACAGACTAA |
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| Protein Properties | |||
| Number of Residues | 1265 | ||
| Molecular Weight | 140478.0 | ||
| Theoretical pI | 4.99 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Methionine synthase MAPTLQDLTPSAGMKKTLQDEIEAILQERIMVLDGGMGTMIQRHKLSEEDFRGQEFKDHA RPLKGNNDILSITQPNVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC SAGVARKAAEDISLQTGIKRYVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYKEQA KGLLDGGVDILLIETIFDTANAKAALFAVQKLFEEEYVPRPVFISGTIVDKSGRTLSGQT GEAFVISVSHADPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDET PHVMAMHLKDFAVDGLVNIVGGCCGTTPDHIREIAEAVKNCKPRVPPATVFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRRFAKLIMAGNYEEALSVAKMQVEMGAQVLDINMDDG MLDGPSAMTRFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD FLEKARKIKKFGAAVVVMAFDEEGQATETDPKIRVCTRAYHLLLKKLGFNPNDIIFDPNI LTIGTGMEEHNLYAVNFINATKVIKETLPGAKVSGGLSNLSFSFRGMEAIREAMHGVFLY HAIKFGMDMGIVNAGSLPVYDDIHKELLQLCEDLIWNRDPEATEKLLHYAQTQGKGGKKV IQTDEWRNGPLEERLEYALVKGIEKYIIEDTEEARLNQEKYPRPLNIIEGPLMNGMKIVG DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETKVLTGKIEDEDPYQGTIVLATV KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM IFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN LKDEYFEEILEEYEDIRQDHYESLKERRYLTLRQARENGFHIDWLSEPPPVKPTFLGTRV FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFDDKTVGEEAKKVYDDAQNMLQAL ISQKKLQARGVVGFWPAQSIQDDIHLYAEGAVPQASEPIATFYGLRQQAEKDSASSDPYL CLSDFIAPLHSGIPDYLGLFAVACFGVEELSKAYEEECDDYSSIMVKALGDRLAEAFAEE LHERARRELWGYCSGEQLAVADLRRLRYEGIRPAPGYPSQPDHTEKLTVWRLADVEQRTG IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQIEDYASRKNMSVAEVEKWLGPIL GYDTD |
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| External Links | |||
| GenBank ID Protein | AAY86762.1 | ||
| UniProtKB/Swiss-Prot ID | Q4JIJ3 | ||
| UniProtKB/Swiss-Prot Entry Name | METH_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | DQ084519 | ||
| GeneCard ID | MTR | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||