| Identification |
|---|
| BMDB Protein ID
| BMDBP00415 |
| Secondary Accession Numbers
| |
| Name
| S-adenosylmethionine decarboxylase proenzyme |
| Synonyms
|
Not Available
|
| Gene Name
| AMD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in adenosylmethionine decarboxylase activity |
| Specific Function
| Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. |
| Pathways
|
- Amine and polyamine biosynthesis
- S-adenosylmethioninamine biosynthesis
- S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1
|
| Reactions
|
| S-Adenosylmethionine → S-Adenosylmethioninamine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| AMD1 |
| Gene Sequence
|
>1005 bp
ATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAACTGCTGGAGGTTTGGTTCTCCAGG
CAGCAACCCGACGCAAACCAAGGATCTGGGGATCTTCGCACCATCCCAAGATCCGAGTGG
GACATACTTTTGAAGGATGTGCAATGTTCAATCATAAGTGTGACAAAAACTGACAAGCAG
GAAGCTTATGTACTCAGTGAGAGTAGCATGTTTGTCTCCAAGAGACGTTTCATTTTGAAG
ACATGTGGTACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGTTGAAACTTGCTAGGGAT
TACAGTGGGTTTGACTCAATTCAAAGCTTCTTTTATTCTCGTAAGAATTTCATGAAGCCT
TCTCACCAAGGGTACCCACACCGGAATTTCCAGGAAGAAATAGAGTTCCTTAATGCAATT
TTCCCAAATGGAGCAGCATATTGTATGGGACGCATGAATTCTGACTGTTGGTACTTGTAT
ACTTTGGATTTCCCAGAGAGTAGGGTAATCAATCAGCCAGATCAAACCCTGGAAATTCTG
ATGAGTGAGCTTGACCCAGCAGTTATGGACCAGTTCTACATGAAAGATGGTGTTACTGCA
AAGGATGTCACTCGTGAGAGTGGAATTCGTGACCTGATACCAGGTTCTGTCATTGATGCC
ACAATGTTCAATCCTTGTGGGTATTCAATGAATGGGATGAAATCGGATGGAACTTATTGG
ACTATTCACATCACTCCAGAACCAGAATTTTCTTATGTTAGCTTTGAAACAAACTTAAGT
CAGACCTCCTATGATGACCTGATCAGGAAAGTTGTGGAAGTCTTCAAGCCAGGAAAATTT
GTGACCACCCTGTTTGTAAATCAGAGTTCTAAATGTCGCACAGTGCTTTCCTCACCCCAG
AAGATTGAAGGTTTTAAACGTCTTGATTGCCAGAGCGCTTTGTTCAATGATTACAATTTT
GTTTTTACCAGTTTTGCTAAGAAGCAGCAACAACAGCAGAGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 38365.0 |
| Theoretical pI
| 5.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>S-adenosylmethionine decarboxylase proenzyme
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVINQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQ
KIEGFKRLDCQSALFNDYNFVFTSFAKKQQQQQS
|
| External Links |
|---|
| GenBank ID Protein
| AAA30359.1 |
| UniProtKB/Swiss-Prot ID
| P50243 |
| UniProtKB/Swiss-Prot Entry Name
| DCAM_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M95605 |
| GeneCard ID
| AMD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
