Showing Protein Protein arginine N-methyltransferase 6 (BMDBP00416)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00416 | ||
| Secondary Accession Numbers | None | ||
| Name | Protein arginine N-methyltransferase 6 | ||
| Synonyms | Not Available | ||
| Gene Name | PRMT6 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in histone binding | ||
| Specific Function | Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (By similarity). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. Methylates GPS2, protecting GPS2 from ubiquitination and degradation. Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity). | ||
| Pathways |
|
||
| Reactions |
|
||
| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 3 | ||
| Locus | Not Available | ||
| SNPs | PRMT6 | ||
| Gene Sequence |
>1128 bp ATGTCGCAGCCCAAGAGAAGAAAGCTTGAGTCGGGGGGCGGCGGCGAAGGAGGGGAGGGA ACTGAAGAGGAAGATGGCGGAGAGTTGGAGGTGGCTGTGCCGCGACCCCGGAGGACTAGG CGGGAGCGGGACCAGCTGTACTACCAGTGCTACTCGGACGTATCGGTCCACGAGGAGATG ATTGCCGACCGCGTCCGCACCGATGCCTACCGCCTGGGCATCCTGCGGAACTGGGCAGCG CTGAGAGGCAAGACCGTGCTGGACGTGGGCGCGGGCACCGGCATCCTCAGCATCTTCTGT GCCCAGGCAGGGGCCCGGCGCGTGTACGCGGTGGAGGCCAGCGACATCTGGCAACAGGCC CGGGAAGTGGTGCGGCTCAACGGGCTGGAGGACCGGGTGCACGTCCTGCCGGGACCGGTG GAGACGGTGGAGTTGCCGGAGCAGGTGGATGCCATCGTGAGCGAGTGGATGGGCTGCGGA CTTCTGCACGAGTCCATGCTGAGCTCTGTGCTCCATGCGCGGACCAAGTGGCTGAAGGAG GGCGGTCTTCTCCTGCCGGCTTCCGCCGAGCTCTTCGTGGCGCCCATCAGCGACCAGATG CTGGAGTTGCGCCTAAGCTTCTGGAGCCAGATGAAGCAACTCTACGGCGTGGACATGAGC TGCCTGGAGAGCTTCGCCACGCGCTGCCTCATGGGCCACTCAGAAATCGTGGTACAAGGC CTCTCCGGCGAGGATGTGCTGGCCCGGCCGCAGTGCTTTGCTCGGCTGGAGCTGGCCCGC GCCGGCCTGGAGCAGGAGCTGGAGGCCGGGGTGGGCGGGCGCTTCCGCTTCAGCTGCTAT GGCTCGGCTCCCATGCACGGCTTTGCCATCTGGTTCCAGGTGACCTTCCCCGGAGGGGAC TCGGAGAAACCCGTGGTGCTCTCCACCTCGCCTTTTCACCCCGTCACGCACTGGAAGCAG GCGCTCCTCTACCTGAACGAGCCGGTGCAAGTGGAGCAAGACACGGATGTTTCCGGAGAG ATCACGCTGCTGCCCTCCCAGGACCACCACCGTCACCTGCGCGTGCTGCTGCGCTACAAA GTGGGCGACCAGGAGGAAAAGACCAAAGACTTTGCCATGGAGGACTGA |
||
| Protein Properties | |||
| Number of Residues | 375 | ||
| Molecular Weight | 41868.0 | ||
| Theoretical pI | 5.1 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
|
||
| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Protein arginine N-methyltransferase 6 MSQPKRRKLESGGGGEGGEGTEEEDGGELEVAVPRPRRTRRERDQLYYQCYSDVSVHEEM IADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASDIWQQA REVVRLNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGCGLLHESMLSSVLHARTKWLKE GGLLLPASAELFVAPISDQMLELRLSFWSQMKQLYGVDMSCLESFATRCLMGHSEIVVQG LSGEDVLARPQCFARLELARAGLEQELEAGVGGRFRFSCYGSAPMHGFAIWFQVTFPGGD SEKPVVLSTSPFHPVTHWKQALLYLNEPVQVEQDTDVSGEITLLPSQDHHRHLRVLLRYK VGDQEEKTKDFAMED |
||
| External Links | |||
| GenBank ID Protein | AAX08922.1 | ||
| UniProtKB/Swiss-Prot ID | Q5E9L5 | ||
| UniProtKB/Swiss-Prot Entry Name | ANM6_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BT020905 | ||
| GeneCard ID | PRMT6 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||