| Identification |
|---|
| BMDB Protein ID
| BMDBP00417 |
| Secondary Accession Numbers
| None |
| Name
| Histone-lysine N-methyltransferase SUV39H1 |
| Synonyms
|
Not Available
|
| Gene Name
| SUV39H1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chromatin binding |
| Specific Function
| Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SUV39H1 |
| Gene Sequence
|
>1239 bp
ATGGCGGAAAGTTTAAAAGGCTGCAGTGTGTGTTGCAAATCTTCTTGGAATCAGCTACAG
GACCTGTGCCGCCTGGCCAAGCTCTCCTGCCCTGCCCTTGGCATCTCCAAGAGGAACCTC
TATGACTTTGAAGTCGAGTACCTGTGCGATTACAAAAAGATCCGCGAACAGGAGTATTAC
CTGGTAAAATGGCGTGGGTACCCAGACTCCGAGAGCACTTGGGAACCACGGCAGAATCTC
AAGTGTGTGCGCATTCTCAAGCAGTTCCACAAGGACTTGGAAAGGGAGCTGCTCCGGCGG
CACCACCGGTCAAAGCCACCCCGGCACCTGGACCCAAGCCTGGCCAACTACCTGGTGCAG
AAGGCCAAGCAGAGGCGGGCACTCCGGCGCTGGGAGCAGGAGCTCAATGCCAAGCGCAGC
CACCTGGGACGCATCACCGTGGAGAACGAAGTGGACCTGGATGGCCCCCCACGGGCCTTC
GTGTACATCAACGAGTACCGTGTTGGTGAGGGCATCACCCTCAACCAGGTGGCTGTGGGC
TGCGAGTGCCAGGACTGTCTGTGGGCACCGGCCGGAGGCTGCTGCCCTGGGGCGTCACTG
CACAAGTTTGCCTACAATGACCAGGGCCAGGTGCGCCTGCGAGCCGGGCTGCCCATCTAT
GAGTGCAACTCCCGCTGCCGCTGTGGCTATGACTGCCCCAACCGCGTGGTACAGAAGGGC
ATCCGCTACGACCTCTGCATCTTCCGCACGGATGATGGACGCGGCTGGGGTGTCCGCACG
CTGGAGAAGATCCGCAAGAACAGTTTCGTCATGGAGTACGTGGGCGAGATCATTACCTCA
GAGGAGGCAGAGCGGCGGGGCCAGATCTATGACCGCCAGGGTGCCACCTACCTCTTCGAC
CTGGACTACGTGGAGGATGTGTACACTGTGGACGCCGCCTATTACGGCAACATCTCTCAC
TTTGTCAACCACAGTTGTGACCCCAACCTCCAGGTGTACAACGTCTTCATAGACAACCTT
GATGAGCGGCTGCCCCGCATTGCTTTCTTTGCCACCAGAACCATCCGGGCAGGCGAGGAG
CTCACCTTTGATTACAACATGCAAGTGGACCCGGTGGACATGGAGAGCACACGCATGGAC
TCCAACTTTGGCCTGGCTGGGCTCCCCGGCTCTCCCAAGAAGCGGGTCCGCATTGAATGC
AAGTGTGGGACTGAATCCTGCCGCAAATACCTCTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 47846.0 |
| Theoretical pI
| 8.07 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SUV39H1
MAESLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYY
LVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKPPRHLDPSLANYLVQ
KAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVG
CECQDCLWAPAGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKG
IRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFD
LDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEE
LTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
|
| External Links |
|---|
| GenBank ID Protein
| AAI11157.1 |
| UniProtKB/Swiss-Prot ID
| Q2NL30 |
| UniProtKB/Swiss-Prot Entry Name
| SUV91_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111156 |
| GeneCard ID
| SUV39H1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
