Showing Protein Histone-lysine N-methyltransferase EZH1 (BMDBP00418)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00418 |
| Secondary Accession Numbers | None |
| Name | Histone-lysine N-methyltransferase EZH1 |
| Synonyms | Not Available |
| Gene Name | EZH1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in DNA binding |
| Specific Function | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | EZH1 |
| Gene Sequence |
>2124 bp ATGGATATACCAAATCCCCCGACGTCCAAATGTATCACTTACTGGAAGAGGAAAGTTAAG TCTGAATACATGCGACTTCGGCAGCTTAAACGGCTTCAGGCGAATATGGGTGCAAAGGCT CTCTATGTAGCAAATTTTGCAAAAGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTTAATGAAGCCTGTGAGTGGGCATCCTTTTCTC AAAAAGTGTACCATAGAGAGCATTTTCCCGGGATTTGCAAGCCAGCACATGTTAATGAGG TCTCTGAACACAGTTGCCTTGGTTCCCATCATGTACTCGTGGTCCCCTCTCCAGCAGAAC TTCATGGTGGAAGATGAGACAGTTTTGTGCAATATCCCCTACATGGGAGATGAGGTGAAA GAGGAAGATGAGACTTTCATTGAGGAGCTGATCAATAACTACGATGGCAAAGTCCACGGT GAAGAAGAGATGATTCCTGGCTCTGTCCTGATCAGTGATGCTGTTTTCCTGGAGTTGGTA GATGCTCTGAATCAATACTCAGATGAAGATGAAGAAGGGCACAACGACACCTCAGATGGA AAGCAAGATGACAGCAAAGAGGATCTGCCAGTAACAAGAAAGAGGAAACGACATGCTATT GAAGGCAGCAAAAAGAGTTCCAAGAAACAATTCCCAAACGACATGATCTTCAGTGCGATC GCCTCGATGTTCCCTGAGAACGGTGTCCCAGACGACATGAAGGAGAGGTACCGAGAGCTC ACAGAGATGTCAGACCCCAATGCGCTCCCCCCGCAGTGCACACCCAACATCGACGGCCCC AACGCCAAGTCTGTGCAGCGGGAACAGTCTCTGCACTCCTTCCACACACTCTTCTGCCGG CGCTGCTTCAAATACGACTGCTTCCTTCACCCTTTCCATGCCACCCCTAATGTGTATAAA CGCAAGAACAAAGAAATCAAGATTGAGCCAGAACCGTGTGGCACAGACTGCTTCCTTCTG CTGGAAGGAGCAAAGGAGTACGCCATGCTGCACAACCCTCGCTCCAAGTGCTCTGGGCGT CGCCGGCGAAGGCACCACGTGGTCAATGCCTCCTGCTCCAACACTTCAGCCTCTGCTGTG GCTGAGACCAAAGAAGGGGACAGCGACAGGGACACTGGCAATGACTGGGCCTCCAGTTCT TCAGAGGCAAACTCACGCTGTCAGACGCCCACGAAACAGAAGGCGAGTCCAGCCCCACCT CAGCTCTGTGTCGTGGAAGCACCCTCAGAACCTGTGGAGTGGACTGGGGCTGAAGAATCT CTTTTTCGAGTCTTTCATGGCACCTACTTCAACAACTTCTGTTCAATAGCCAGACTTCTG GGGACTAAGACATGCAAGCAGGTCTTCCAGTTTGCAGTCAAAGAGTCACTTATCCTGAAG CTGCCCACAGATGAGCTTATGAACCCCTCGCAGAAGAAGAAGAGAAAGCACAGGTTGTGG GCTGCACACTGCCGGAAAATTCAGCTGAAGAAAGATAACTCCTCCACCCAGGTGTACAAC TACCAGCCCTGCGACCACCCGGACCGCCCCTGTGACAGCACGTGCCCCTGCATCATGACT CAGAATTTCTGTGAGAAGTTCTGCCAGTGCAACCCCGACTGTCAGAATCGCTTTCCCGGC TGTCGCTGTAAGACCCAGTGCAATACCAAGCAGTGCCCGTGCTACCTGGCGGTGCGCGAG TGTGACCCTGACCTGTGCCTCACCTGTGGGGCCTCGGAGCACTGGGACTGCAAGGTGGTT TCCTGTAAGAACTGCAGCATTCAACGTGGCCTCAAAAAGCACCTGCTGCTGGCCCCCTCA GATGTGGCCGGATGGGGCACCTTCATTAAGGAGTCTGTGCAGAAGAATGAATTCATTTCT GAATACTGTGGTGAGCTCATCTCTCAGGATGAGGCCGATCGACGAGGGAAGGTCTATGAC AAGTACATGTCCAGCTTCCTCTTCAACCTCAATAACGATTTTGTAGTGGATGCTACCCGG AAAGGAAACAAAATTCGATTTGCAAACCATTCGGTGAACCCCAACTGTTATGCCAAAGCC AAAATAACAGATCTAAAAGCATAG |
| Protein Properties | |
| Number of Residues | 747 |
| Molecular Weight | 85285.0 |
| Theoretical pI | 7.77 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Histone-lysine N-methyltransferase EZH1 MDIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW KKLRVQPVQLMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV DALNQYSDEDEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGSKKSSKKQFPNDMIFSAI ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR RRRRHHVVNASCSNTSASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG EELFFDYRYSQADALKYVGIERETDVL |
| External Links | |
| GenBank ID Protein | AAI51627.1 |
| UniProtKB/Swiss-Prot ID | A7E2Z2 |
| UniProtKB/Swiss-Prot Entry Name | EZH1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC151626 |
| GeneCard ID | EZH1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |