Showing Protein Histone-lysine N-methyltransferase KMT5B (BMDBP00419)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00419 |
| Secondary Accession Numbers | None |
| Name | Histone-lysine N-methyltransferase KMT5B |
| Synonyms | Not Available |
| Gene Name | KMT5B |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in histone-lysine N-methyltransferase activity |
| Specific Function | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | Not Available |
| Locus | Not Available |
| SNPs | KMT5B |
| Gene Sequence |
>1182 bp ATGAAGTGGTTGGGAGAATCCAAGAACATGGTGGTGAATGGCAGGAGACATGGAGGCAAG TTGTCTAATGACCATCAGCAGAATCAATCAAAGTTACAGCACTCGGGAAAGGACAACGTG AAGGCTGGCAGAAACGCAGGCGAGAGGAGGTCGAGCAGATGTAATGGGAACTCAGGCTTT GAGGGACAGAGTCGATATGTACCATCTTCTGGAATGTCTGCCAAGGAACTCTGTGAAAAT GATGACCTAGCGACCAGTTTGGTTCTTGATCCCTATTTAGGTTTTCAAACACACAAAATG AATACTAGCGCCTTTCCTCCGAGGAGCTCAAGGCATTTTTCAAAATCTGACAGTTTTTCT CACAACAACCCTGTAAGATTTCGGCCTATTAAAGGAAGGCAGGAAGAACTCAAAGAAGTA ATTGAACGTTTTAAGAAAGATGAGCACTTGGAGAAAGCCTTCAAATGTCTGACTTCAGGA GAATGGGCACGGCACTATTTTCTCAACAAGAACAAAATGCAGGAGAAATTATTCAAGGAA CATGTATTTATTTATTTGCGAATGTTTGCAACTGACAGTGGATTTGAAATATTGCCTTGT AATAGATACTCTTCAGAACAAAATGGAGCCAAAATAGTTGCAACGAAAGAGTGGAAACGA AATGACAAAATAGAATTACTGGTGGGTTGTATTGCCGAACTTTCAGAAATTGAGGAGAAC ATGCTGCTTAGACATGGAGAAAACGACTTCAGTGTCATGTATTCCACAAGGAAAAACTGT GCTCAGCTCTGGCTTGGTCCTGCTGCATTTATAAACCATGATTGCAGACCTAACTGTAAG TTTGTGTCAACTGGTCGAGATACAGCATGTGTGAAGGCCCTAAGAGATATTGAACCTGGA GAAGAAATTTCTTGTTATTATGGAGATGGGTTTTTTGGAGAAAACAATGAGTTCTGCGAG TGTTACACTTGTGAAAGACGGGGAACTGGTGCTTTTAAATCCAGAGTGGGACTGCCTGCG CCTGCTCCTGTTATCAATAGCAAATACGGACTCAGAGAAACAGATAAACGTTTAAATAGG CTTAAAAAGTTAGGTGACAGCAGCAAAAACTCAGACAGTCAGTCTGTCAGCTCCAACACT GACGCAGACACCACTCAGGGAAGAAACGACGCAAGTAAGTAG |
| Protein Properties | |
| Number of Residues | 393 |
| Molecular Weight | 44552.0 |
| Theoretical pI | 8.91 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence |
>Histone-lysine N-methyltransferase SUV420H1 MKWLGESKNMVVNGRRHGGKLSNDHQQNQSKLQHSGKDNVKAGRNAGERRSSRCNGNSGF EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPPRSSRHFSKSDSFS HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR LKKLGDSSKNSDSQSVSSNTDADTTQGRNDASK |
| External Links | |
| GenBank ID Protein | AAI14080.1 |
| UniProtKB/Swiss-Prot ID | Q29RP8 |
| UniProtKB/Swiss-Prot Entry Name | KMT5B_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC114079 |
| GeneCard ID | KMT5B |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |