Showing Protein Catechol O-methyltransferase (BMDBP00421)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 19 metabolites
Identification
BMDB Protein ID BMDBP00421
Secondary Accession Numbers None
Name Catechol O-methyltransferase
Synonyms Not Available
Gene Name COMT
Protein Type Enzyme
Biological Properties
General Function Involved in catechol O-methyltransferase activity
Specific Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity).
Pathways
  • Estrone Metabolism
  • Tyrosine Metabolism
Reactions
Norepinephrine + Guaiacol → Normetanephrine + Pyrocatechol details
Epinephrine + Guaiacol → Metanephrine + Pyrocatechol details
3,4-Dihydroxyphenylglycol + Guaiacol → Vanylglycol + Pyrocatechol details
3,4-Dihydroxymandelic acid + Guaiacol → Vanillylmandelic acid + Pyrocatechol details
Dopamine + Guaiacol → 3-Methoxytyramine + Pyrocatechol details
3,4-Dihydroxybenzeneacetic acid + Guaiacol → Homovanillic acid + Pyrocatechol details
S-Adenosylmethionine + 2-Hydroxyestrone → 2-Methoxyestrone + S-Adenosylhomocysteine details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 17
Locus Not Available
SNPs COMT
Gene Sequence 
>819 bp
ATGCTGGAGGCCCCGCCCCTGCTGCTGGTCGCTGGTGGCGTAGGCCTGGCCCTGCTCGCG
CTGCGGTGGCTGGCCACAACGGACCTGCAGTTCTTCGGCCGGGCCTTTATCGTCTGGAAC
GAGTTCATCATGAAGCCCATCCGCAACCTCCTCATGGGCAGCAGCAAGGAGCAGCGCATC
CTGCAGCACGTGCTGCAGCACGCGGTGGCCGGGGACCCGCAGAGCGTGGTGGCCGCCATC
GACAGCTACAGCTTGGAGAAGGAGTGGGCCATGCACGTGGGCGAGAAGAAAGGCCAGATC
GTGGACAGGGTGCTGAGGGAACAGCAGCCGTCCGTACTGCTGGAGCTGGGCGCCTACTGC
GGCTACTCGGCAGTGCGAATGGCCCGCCTGCTGCTGCCCGGCGCCCGGCTGCTCACCATC
GAGTTCAATCCCGACTATGCCGCCATCACCCAGCGGATGGTGGAGTTTGCAGGCCTGCAG
GACAAGGTCACCGTTGTTCTTGGAGCATCCCAGGACATCATCCCCCAGCTGAAGAAGAAA
TACGATGTGGACACCCTGGACATGGTCTTTCTCGACCACTGGAAGGACCGCTACCTGCCG
GACATGCTTCTCCTGGAGGAGTGCGGCCTGCTGCGGGAGGGGACAGTGTTGCTGGCTGAC
AACGTCATCTACCCTGGGGCGCCCGACTTTCTGGAGTACGTGCGCGGGAACAGCCGCTTC
GAATGTTCGCACTTCAGCTCGTACCTGGAGTACTCCAAGGTGGTGGACGGCTTGGAGAAG
GTCGTCTACAAGGGCCTGAGCGGCCCTGCTCGGCCCTGA
Protein Properties
Number of Residues 272
Molecular Weight 30485.0
Theoretical pI 5.69
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 7-27
Protein Sequence 
>Catechol O-methyltransferase
MLEAPPLLLVAGGVGLALLALRWLATTDLQFFGRAFIVWNEFIMKPIRNLLMGSSKEQRI
LQHVLQHAVAGDPQSVVAAIDSYSLEKEWAMHVGEKKGQIVDRVLREQQPSVLLELGAYC
GYSAVRMARLLLPGARLLTIEFNPDYAAITQRMVEFAGLQDKVTVVLGASQDIIPQLKKK
YDVDTLDMVFLDHWKDRYLPDMLLLEECGLLREGTVLLADNVIYPGAPDFLEYVRGNSRF
ECSHFSSYLEYSKVVDGLEKVVYKGLSGPARP
GenBank ID Protein AAI51586.1
UniProtKB/Swiss-Prot ID A7MBI7
UniProtKB/Swiss-Prot Entry Name COMT_BOVIN
PDB IDs Not Available
GenBank Gene ID BC151585
GeneCard ID COMT
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available