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| Identification |
|---|
| BMDB Protein ID
| BMDBP00421 |
| Secondary Accession Numbers
| None |
| Name
| Catechol O-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| COMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catechol O-methyltransferase activity |
| Specific Function
| Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity). |
| Pathways
|
- Estrone Metabolism
- Tyrosine Metabolism
|
| Reactions
|
| Norepinephrine + Guaiacol → Normetanephrine + Pyrocatechol |
details
|
| Epinephrine + Guaiacol → Metanephrine + Pyrocatechol |
details
|
| 3,4-Dihydroxyphenylglycol + Guaiacol → Vanylglycol + Pyrocatechol |
details
|
| 3,4-Dihydroxymandelic acid + Guaiacol → Vanillylmandelic acid + Pyrocatechol |
details
|
| Dopamine + Guaiacol → 3-Methoxytyramine + Pyrocatechol |
details
|
| 3,4-Dihydroxybenzeneacetic acid + Guaiacol → Homovanillic acid + Pyrocatechol |
details
|
| S-Adenosylmethionine + 2-Hydroxyestrone → 2-Methoxyestrone + S-Adenosylhomocysteine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| COMT |
| Gene Sequence
|
>819 bp
ATGCTGGAGGCCCCGCCCCTGCTGCTGGTCGCTGGTGGCGTAGGCCTGGCCCTGCTCGCG
CTGCGGTGGCTGGCCACAACGGACCTGCAGTTCTTCGGCCGGGCCTTTATCGTCTGGAAC
GAGTTCATCATGAAGCCCATCCGCAACCTCCTCATGGGCAGCAGCAAGGAGCAGCGCATC
CTGCAGCACGTGCTGCAGCACGCGGTGGCCGGGGACCCGCAGAGCGTGGTGGCCGCCATC
GACAGCTACAGCTTGGAGAAGGAGTGGGCCATGCACGTGGGCGAGAAGAAAGGCCAGATC
GTGGACAGGGTGCTGAGGGAACAGCAGCCGTCCGTACTGCTGGAGCTGGGCGCCTACTGC
GGCTACTCGGCAGTGCGAATGGCCCGCCTGCTGCTGCCCGGCGCCCGGCTGCTCACCATC
GAGTTCAATCCCGACTATGCCGCCATCACCCAGCGGATGGTGGAGTTTGCAGGCCTGCAG
GACAAGGTCACCGTTGTTCTTGGAGCATCCCAGGACATCATCCCCCAGCTGAAGAAGAAA
TACGATGTGGACACCCTGGACATGGTCTTTCTCGACCACTGGAAGGACCGCTACCTGCCG
GACATGCTTCTCCTGGAGGAGTGCGGCCTGCTGCGGGAGGGGACAGTGTTGCTGGCTGAC
AACGTCATCTACCCTGGGGCGCCCGACTTTCTGGAGTACGTGCGCGGGAACAGCCGCTTC
GAATGTTCGCACTTCAGCTCGTACCTGGAGTACTCCAAGGTGGTGGACGGCTTGGAGAAG
GTCGTCTACAAGGGCCTGAGCGGCCCTGCTCGGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 272 |
| Molecular Weight
| 30485.0 |
| Theoretical pI
| 5.69 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Catechol O-methyltransferase
MLEAPPLLLVAGGVGLALLALRWLATTDLQFFGRAFIVWNEFIMKPIRNLLMGSSKEQRI
LQHVLQHAVAGDPQSVVAAIDSYSLEKEWAMHVGEKKGQIVDRVLREQQPSVLLELGAYC
GYSAVRMARLLLPGARLLTIEFNPDYAAITQRMVEFAGLQDKVTVVLGASQDIIPQLKKK
YDVDTLDMVFLDHWKDRYLPDMLLLEECGLLREGTVLLADNVIYPGAPDFLEYVRGNSRF
ECSHFSSYLEYSKVVDGLEKVVYKGLSGPARP
|
| External Links |
|---|
| GenBank ID Protein
| AAI51586.1 |
| UniProtKB/Swiss-Prot ID
| A7MBI7 |
| UniProtKB/Swiss-Prot Entry Name
| COMT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151585 |
| GeneCard ID
| COMT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
