Showing Protein tRNA (guanine-N(7)-)-methyltransferase (BMDBP00423)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00423 |
| Secondary Accession Numbers | None |
| Name | tRNA (guanine-N(7)-)-methyltransferase |
| Synonyms | Not Available |
| Gene Name | METTL1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in tRNA (guanine-N7-)-methyltransferase activity |
| Specific Function | Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 5 |
| Locus | Not Available |
| SNPs | METTL1 |
| Gene Sequence |
>834 bp ATGGCGGGAACCGAGACTGGGGACGCAGCAGGAACCGAGGCCCCACAGCCTCAGAAGCGC TACTATCGGCAGCGGGCTCACTCCAACCCCATGGCGGATCATACGCTGCGCTACCCTGTG AAACCAGAGGACATGGACTGGTCTGAGCTATACCCAGAGTTCTTCGCTCCACTGCCTCAA AATCAGAGCCATGATGACCCAAAGGATAAGAAAGAAAAGAGAGCTCAGGCTCAAGTGGAG TTTGCAGACATAGGCTGTGGCTATGGCGGCCTGTTAGTGGAACTGTCACCGCTGTTCCCA GACACGCTGATTCTGGGTCTGGAGATCCGGGTGAAAGTCTCAGACTATGTACAAGACCGG ATCCGGGCCCTGCGAGCCGCTCCTGGAGGTGGTTTCCAGAACATCGCCTGTCTCCGCAGC AATGCCATGAAGCACCTTCCTAACTTCTTCCACAAGGGCCAGCTGACAAAGATGTTCTTC CTCTTCCCTGACCCACATTTCAAGCGGACGAAGCACAAGTGGCGAATCATCAGTCCCACA CTGCTGGCAGAATATGCCTACGTGCTGAGAGTTGGGGGGCTGGTGTACACCATAACTGAC GTGCTGGAGCTGCATGAGTGGATGTGCACCCACTTTGAAGGGCACCCCTTGTTTGAGCGT GTGCCTCTGGAGGAGCTGAGTGAAGACCCCATTGTGGGACATCTGGGCACCTCAACCGAG GAGGGAAAGAAAGTTCTACGCAATGGAGGAAAGAACTTCCCAGCCATCTTCCGAAGAATA CAGGATCCCGCCCTCCCGGCAGTGACTCCCACTCCTACCCCTCCTGGTCACTGA |
| Protein Properties | |
| Number of Residues | 277 |
| Molecular Weight | 31323.0 |
| Theoretical pI | 7.41 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>tRNA (guanine-N(7)-)-methyltransferase MAGTETGDAAGTEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEDMDWSELYPEFFAPLPQ NQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDR IRALRAAPGGGFQNIACLRSNAMKHLPNFFHKGQLTKMFFLFPDPHFKRTKHKWRIISPT LLAEYAYVLRVGGLVYTITDVLELHEWMCTHFEGHPLFERVPLEELSEDPIVGHLGTSTE EGKKVLRNGGKNFPAIFRRIQDPALPAVTPTPTPPGH |
| External Links | |
| GenBank ID Protein | ABM06158.1 |
| UniProtKB/Swiss-Prot ID | Q2YDF1 |
| UniProtKB/Swiss-Prot Entry Name | TRMB_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BT029912 |
| GeneCard ID | METTL1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |